<em>Lactobacillus reuteri</em> DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial
The main objective was to assess the efficacy of a probiotic (<i>Lactobacillus reuteri</i> DSM 17938), a prebiotic (agave inulin), and a synbiotic on the stool characteristics in children with cerebral palsy and chronic constipation. Thirty-seven children with cerebral palsy and chronic...
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MDPI AG
2020-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/10/2971 |
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| author | Andrea A. García Contreras Edgar M. Vásquez Garibay Carmen A. Sánchez Ramírez Mary Fafutis Morris Vidal Delgado Rizo |
| author_facet | Andrea A. García Contreras Edgar M. Vásquez Garibay Carmen A. Sánchez Ramírez Mary Fafutis Morris Vidal Delgado Rizo |
| author_sort | Andrea A. García Contreras |
| collection | DOAJ |
| description | The main objective was to assess the efficacy of a probiotic (<i>Lactobacillus reuteri</i> DSM 17938), a prebiotic (agave inulin), and a synbiotic on the stool characteristics in children with cerebral palsy and chronic constipation. Thirty-seven children with cerebral palsy and chronic constipation were included. The probiotic group received 1 × 10<sup>8</sup> colony forming unit (cfu) of <i>L. reuteri</i> DSM 17938 plus placebo, the prebiotic group received 4 g of agave inulin plus placebo, the synbiotic group received <i>L. reuteri</i> DSM 17938 plus agave inulin, and the placebo group received two placebos for 28 days. The probiotic group showed a significant decrease in stool pH (<i>p</i> = 0.014). Stool consistency improved in the prebiotic group (<i>p</i> = 0.008). The probiotic, prebiotic, and synbiotic groups showed a significant improvement in the history of excessive stool retention, the presence of fecal mass in the rectum, and the history of painful defecation. <i>L. reuteri</i> concentration in feces was higher in the probiotic group than in the placebo group (<i>p</i> = 0.001) and showed an inverse correlation with stool pH in the probiotic group (<i>r</i> = −0.762, <i>p</i> = 0.028). This study showed that the use of <i>L. reuteri</i> DSM 17938 and/or agave inulin improved the stool characteristics such as the history of painful defecation and the presence of fecal mass in the rectum against placebo in children with cerebral palsy and chronic constipation. |
| first_indexed | 2024-03-10T15:59:16Z |
| format | Article |
| id | doaj.art-e6f13fd1ecdb4b10a2988013393d67af |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T15:59:16Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e6f13fd1ecdb4b10a2988013393d67af2023-11-20T15:27:03ZengMDPI AGNutrients2072-66432020-09-011210297110.3390/nu12102971<em>Lactobacillus reuteri</em> DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical TrialAndrea A. García Contreras0Edgar M. Vásquez Garibay1Carmen A. Sánchez Ramírez2Mary Fafutis Morris3Vidal Delgado Rizo4Departamento de Nutrición y Bienestar Integral, Escuela de Medicina, Instituto Tecnológico y de Estudios Superiores Monterrey Campus Guadalajara, C.P. 4520 Zapopan, Jalisco, MexicoDepartamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, C.P. 44340 Guadalajara, Jalisco, MexicoDepartamento de la Facultad de Medicina, Facultad de Medicina, Universidad de Colima, C.P. 28040 Colima, Colima, MexicoDepartamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, C.P. 44340 Guadalajara, Jalisco, MexicoDepartamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, C.P. 44340 Guadalajara, Jalisco, MexicoThe main objective was to assess the efficacy of a probiotic (<i>Lactobacillus reuteri</i> DSM 17938), a prebiotic (agave inulin), and a synbiotic on the stool characteristics in children with cerebral palsy and chronic constipation. Thirty-seven children with cerebral palsy and chronic constipation were included. The probiotic group received 1 × 10<sup>8</sup> colony forming unit (cfu) of <i>L. reuteri</i> DSM 17938 plus placebo, the prebiotic group received 4 g of agave inulin plus placebo, the synbiotic group received <i>L. reuteri</i> DSM 17938 plus agave inulin, and the placebo group received two placebos for 28 days. The probiotic group showed a significant decrease in stool pH (<i>p</i> = 0.014). Stool consistency improved in the prebiotic group (<i>p</i> = 0.008). The probiotic, prebiotic, and synbiotic groups showed a significant improvement in the history of excessive stool retention, the presence of fecal mass in the rectum, and the history of painful defecation. <i>L. reuteri</i> concentration in feces was higher in the probiotic group than in the placebo group (<i>p</i> = 0.001) and showed an inverse correlation with stool pH in the probiotic group (<i>r</i> = −0.762, <i>p</i> = 0.028). This study showed that the use of <i>L. reuteri</i> DSM 17938 and/or agave inulin improved the stool characteristics such as the history of painful defecation and the presence of fecal mass in the rectum against placebo in children with cerebral palsy and chronic constipation.https://www.mdpi.com/2072-6643/12/10/2971cerebral palsy<i>Lactobacillus reuteri</i> DSM 17938agave inulinchronic constipationchildren |
| spellingShingle | Andrea A. García Contreras Edgar M. Vásquez Garibay Carmen A. Sánchez Ramírez Mary Fafutis Morris Vidal Delgado Rizo <em>Lactobacillus reuteri</em> DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial Nutrients cerebral palsy <i>Lactobacillus reuteri</i> DSM 17938 agave inulin chronic constipation children |
| title | <em>Lactobacillus reuteri</em> DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial |
| title_full | <em>Lactobacillus reuteri</em> DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial |
| title_fullStr | <em>Lactobacillus reuteri</em> DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial |
| title_full_unstemmed | <em>Lactobacillus reuteri</em> DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial |
| title_short | <em>Lactobacillus reuteri</em> DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial |
| title_sort | em lactobacillus reuteri em dsm 17938 and agave inulin in children with cerebral palsy and chronic constipation a double blind randomized placebo controlled clinical trial |
| topic | cerebral palsy <i>Lactobacillus reuteri</i> DSM 17938 agave inulin chronic constipation children |
| url | https://www.mdpi.com/2072-6643/12/10/2971 |
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