Effect of Oxymatrine Combined with Low Dose 5-FU on Lymphatic Vessel and Microvascular Endothelial Cell Growth of Gastric Cancer in a Severe Combined Immunodeficient Mouse Orthotopic Implantation Model
In this study, we explored the effect of Oxymatrine combined with low dose 5-Fu on lymphatic vessel and vascular endothelial growth factor of orthotopic implantated gastric cancer in severe combined immunodeficient (SCID) nude mice. Human gastric cancer cell line SGC-7901 was orthotopically implante...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2011-01-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X1100900107 |
| _version_ | 1828849719706648576 |
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| author | J-S. Zhu Z-P. Xu M-Q. Song Q. Zhang |
| author_facet | J-S. Zhu Z-P. Xu M-Q. Song Q. Zhang |
| author_sort | J-S. Zhu |
| collection | DOAJ |
| description | In this study, we explored the effect of Oxymatrine combined with low dose 5-Fu on lymphatic vessel and vascular endothelial growth factor of orthotopic implantated gastric cancer in severe combined immunodeficient (SCID) nude mice. Human gastric cancer cell line SGC-7901 was orthotopically implanted into the gastric tract of nude mice. Nude mice were treated with normal saline (control group), low dose 5-Fu, oxymatrine, oxymatrine combined with low dose 5-Fu using intraperitoneal injection. The expression of LVD, VEGF-C, VEGF-D, VEGF-R-3 and their Ct were analyzed in a severe combined immunodeficient mouse orthotopic implantatation gastric cancer model. We found that oxymatrine combined with low dose 5-Fu could decrease LVD and inhibit VEGF expression by a synergistic effect in SCID nude mouse orthotopic implantatation gastric cancer model. |
| first_indexed | 2024-12-12T22:56:09Z |
| format | Article |
| id | doaj.art-e6f1f417bdf34823beaf6f8bcd3a1b79 |
| institution | Directory Open Access Journal |
| issn | 1721-727X |
| language | English |
| last_indexed | 2024-12-12T22:56:09Z |
| publishDate | 2011-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-e6f1f417bdf34823beaf6f8bcd3a1b792022-12-22T00:08:56ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2011-01-01910.1177/1721727X1100900107Effect of Oxymatrine Combined with Low Dose 5-FU on Lymphatic Vessel and Microvascular Endothelial Cell Growth of Gastric Cancer in a Severe Combined Immunodeficient Mouse Orthotopic Implantation ModelJ-S. ZhuZ-P. XuM-Q. SongQ. ZhangIn this study, we explored the effect of Oxymatrine combined with low dose 5-Fu on lymphatic vessel and vascular endothelial growth factor of orthotopic implantated gastric cancer in severe combined immunodeficient (SCID) nude mice. Human gastric cancer cell line SGC-7901 was orthotopically implanted into the gastric tract of nude mice. Nude mice were treated with normal saline (control group), low dose 5-Fu, oxymatrine, oxymatrine combined with low dose 5-Fu using intraperitoneal injection. The expression of LVD, VEGF-C, VEGF-D, VEGF-R-3 and their Ct were analyzed in a severe combined immunodeficient mouse orthotopic implantatation gastric cancer model. We found that oxymatrine combined with low dose 5-Fu could decrease LVD and inhibit VEGF expression by a synergistic effect in SCID nude mouse orthotopic implantatation gastric cancer model.https://doi.org/10.1177/1721727X1100900107 |
| spellingShingle | J-S. Zhu Z-P. Xu M-Q. Song Q. Zhang Effect of Oxymatrine Combined with Low Dose 5-FU on Lymphatic Vessel and Microvascular Endothelial Cell Growth of Gastric Cancer in a Severe Combined Immunodeficient Mouse Orthotopic Implantation Model European Journal of Inflammation |
| title | Effect of Oxymatrine Combined with Low Dose 5-FU on Lymphatic Vessel and Microvascular Endothelial Cell Growth of Gastric Cancer in a Severe Combined Immunodeficient Mouse Orthotopic Implantation Model |
| title_full | Effect of Oxymatrine Combined with Low Dose 5-FU on Lymphatic Vessel and Microvascular Endothelial Cell Growth of Gastric Cancer in a Severe Combined Immunodeficient Mouse Orthotopic Implantation Model |
| title_fullStr | Effect of Oxymatrine Combined with Low Dose 5-FU on Lymphatic Vessel and Microvascular Endothelial Cell Growth of Gastric Cancer in a Severe Combined Immunodeficient Mouse Orthotopic Implantation Model |
| title_full_unstemmed | Effect of Oxymatrine Combined with Low Dose 5-FU on Lymphatic Vessel and Microvascular Endothelial Cell Growth of Gastric Cancer in a Severe Combined Immunodeficient Mouse Orthotopic Implantation Model |
| title_short | Effect of Oxymatrine Combined with Low Dose 5-FU on Lymphatic Vessel and Microvascular Endothelial Cell Growth of Gastric Cancer in a Severe Combined Immunodeficient Mouse Orthotopic Implantation Model |
| title_sort | effect of oxymatrine combined with low dose 5 fu on lymphatic vessel and microvascular endothelial cell growth of gastric cancer in a severe combined immunodeficient mouse orthotopic implantation model |
| url | https://doi.org/10.1177/1721727X1100900107 |
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