Prognosis of Differentiated Thyroid Carcinoma with Initial Distant Metastasis: A Multicenter Study in Korea
BackgroundMost patients with differentiated thyroid cancer (DTC) have a favorable prognosis. However, patients with DTC and initial distant metastasis have not been commonly found, and their clinical characteristics have seldom been reported. In this study, we analyzed the clinical features and prog...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2018-06-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-33-287.pdf |
| _version_ | 1819048809664086016 |
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| author | Hosu Kim Hye In Kim Sun Wook Kim Jaehoon Jung Min Ji Jeon Won Gu Kim Tae Yong Kim Hee Kyung Kim Ho-Cheol Kang Ji Min Han Yoon Young Cho Tae Hyuk Kim Jae Hoon Chung |
| author_facet | Hosu Kim Hye In Kim Sun Wook Kim Jaehoon Jung Min Ji Jeon Won Gu Kim Tae Yong Kim Hee Kyung Kim Ho-Cheol Kang Ji Min Han Yoon Young Cho Tae Hyuk Kim Jae Hoon Chung |
| author_sort | Hosu Kim |
| collection | DOAJ |
| description | BackgroundMost patients with differentiated thyroid cancer (DTC) have a favorable prognosis. However, patients with DTC and initial distant metastasis have not been commonly found, and their clinical characteristics have seldom been reported. In this study, we analyzed the clinical features and prognosis of patients with DTC and initial distant metastasis in Korea.MethodsWe retrospectively reviewed the clinical data of 242 patients with DTC and initial distant metastasis treated from 1994 to 2013, collected from five tertiary hospitals in Korea.ResultsThe patients' median age was 51 years, and 65% were women. They were followed for a median of 7 years. Lung was the most common site of distant metastasis: only lung 149 patients (62%), only bone 49 (20%), other single site one (pleura), and combined sites 43 (40 were lung and bone, two were bone and other site, and one was lung and other site). At the time of diagnosis, 50 patients (21%) had non-radioactive iodine (RAI) avidity. Five-year disease-specific survival (DSS) was 85% and 10-year DSS was 68%, which were better than those in previous studies. After multivariate analysis, old age, male sex, metastatic site, and histologic type (follicular type) were significant factors for poor prognosis. However, negative RAI avidity status was not a significant prognostic factor after adjusting for other variables.ConclusionThe prognosis of Korean patients with DTC and initial distant metastasis was better than in previous studies. Old age, male sex, metastasis site, and histologic type were significant prognostic factors. |
| first_indexed | 2024-12-21T11:22:10Z |
| format | Article |
| id | doaj.art-e6f2aee03f2c4663a691537ed83dd6a6 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-21T11:22:10Z |
| publishDate | 2018-06-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-e6f2aee03f2c4663a691537ed83dd6a62022-12-21T19:05:45ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782018-06-0133228729510.3803/EnM.2018.33.2.287Prognosis of Differentiated Thyroid Carcinoma with Initial Distant Metastasis: A Multicenter Study in KoreaHosu Kim0Hye In Kim1Sun Wook Kim2Jaehoon Jung3Min Ji Jeon4Won Gu Kim5Tae Yong Kim6Hee Kyung Kim7Ho-Cheol Kang8Ji Min Han9Yoon Young Cho10Tae Hyuk Kim11Jae Hoon Chung12Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, .KoreaDivision of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, .KoreaDivision of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, .KoreaDivision of Endocrinology, Department of Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, .KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, .KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, .KoreaDivision of Endocrinology and Metabolism, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, .KoreaDivision of Endocrinology and Metabolism, Department of Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, .KoreaDivision of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, .KoreaDivision of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, .KoreaBackgroundMost patients with differentiated thyroid cancer (DTC) have a favorable prognosis. However, patients with DTC and initial distant metastasis have not been commonly found, and their clinical characteristics have seldom been reported. In this study, we analyzed the clinical features and prognosis of patients with DTC and initial distant metastasis in Korea.MethodsWe retrospectively reviewed the clinical data of 242 patients with DTC and initial distant metastasis treated from 1994 to 2013, collected from five tertiary hospitals in Korea.ResultsThe patients' median age was 51 years, and 65% were women. They were followed for a median of 7 years. Lung was the most common site of distant metastasis: only lung 149 patients (62%), only bone 49 (20%), other single site one (pleura), and combined sites 43 (40 were lung and bone, two were bone and other site, and one was lung and other site). At the time of diagnosis, 50 patients (21%) had non-radioactive iodine (RAI) avidity. Five-year disease-specific survival (DSS) was 85% and 10-year DSS was 68%, which were better than those in previous studies. After multivariate analysis, old age, male sex, metastatic site, and histologic type (follicular type) were significant factors for poor prognosis. However, negative RAI avidity status was not a significant prognostic factor after adjusting for other variables.ConclusionThe prognosis of Korean patients with DTC and initial distant metastasis was better than in previous studies. Old age, male sex, metastasis site, and histologic type were significant prognostic factors.https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-33-287.pdfDifferentiated thyroid cancerNeoplasm metastasisRadioactive iodinePrognosis |
| spellingShingle | Hosu Kim Hye In Kim Sun Wook Kim Jaehoon Jung Min Ji Jeon Won Gu Kim Tae Yong Kim Hee Kyung Kim Ho-Cheol Kang Ji Min Han Yoon Young Cho Tae Hyuk Kim Jae Hoon Chung Prognosis of Differentiated Thyroid Carcinoma with Initial Distant Metastasis: A Multicenter Study in Korea Endocrinology and Metabolism Differentiated thyroid cancer Neoplasm metastasis Radioactive iodine Prognosis |
| title | Prognosis of Differentiated Thyroid Carcinoma with Initial Distant Metastasis: A Multicenter Study in Korea |
| title_full | Prognosis of Differentiated Thyroid Carcinoma with Initial Distant Metastasis: A Multicenter Study in Korea |
| title_fullStr | Prognosis of Differentiated Thyroid Carcinoma with Initial Distant Metastasis: A Multicenter Study in Korea |
| title_full_unstemmed | Prognosis of Differentiated Thyroid Carcinoma with Initial Distant Metastasis: A Multicenter Study in Korea |
| title_short | Prognosis of Differentiated Thyroid Carcinoma with Initial Distant Metastasis: A Multicenter Study in Korea |
| title_sort | prognosis of differentiated thyroid carcinoma with initial distant metastasis a multicenter study in korea |
| topic | Differentiated thyroid cancer Neoplasm metastasis Radioactive iodine Prognosis |
| url | https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-33-287.pdf |
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