A systematic review and meta-analysis on the association of serum and tumor tissue iron and risk of breast cancer
Background: Some studies have investigated the effects of iron on breast carcinogenesis and reported different findings about the association between Fe and breast cancer risk. This study was conducted to estimate this effect using meta-analysis method. Methods: A total of 20 articles published betw...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2020-01-01
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| Series: | Caspian Journal of Internal Medicine |
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| Online Access: | http://caspjim.com/article-1-1674-en.html |
| _version_ | 1818164176291364864 |
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| author | Akram Sanagoo Faezeh Kiani Marzieh Saei Gharenaz Fatemeh Sayehmiri Fatemeh koohi Leila Jouybari Majid Dousti |
| author_facet | Akram Sanagoo Faezeh Kiani Marzieh Saei Gharenaz Fatemeh Sayehmiri Fatemeh koohi Leila Jouybari Majid Dousti |
| author_sort | Akram Sanagoo |
| collection | DOAJ |
| description | Background: Some studies have investigated the effects of iron on breast carcinogenesis and reported different findings about the association between Fe and breast cancer risk. This study was conducted to estimate this effect using meta-analysis method.
Methods: A total of 20 articles published between 1984 and 2017 worldwide were selected through searching PubMed, Scopus, Embase, Web of Science, and Cochrane Library. Keywords such Breast Cancer, Neoplasm, Trace elements, Iron, Breast tissue concentration, Plasma concentration, Scalp hair concentration, toenail concentration and their combination were used in the search.
Results: The total number of participants was 4,110 individuals comprising 1,624 patients with breast cancer and 2,486 healthy subjects. Fe concentration was measured in the various subgroups in both case and control groups. There were significant correlations between Fe concentration and breast cancer in breast tissue subgroup (SMD: 0.67 [95% CI: 0.17 to 1.17; P=0.009]). Whereas, there was no meaningful difference in Fe status between women with and without breast cancer related to scalp hair and plasma subgroups; (SMD: -3.74 [95% CI: -7.58 to 0.10; P=0.056] and (SMD:-1.14[95% CI: -2.30 to 0.03; P=0.055], respectively.
Conclusion: The present meta-analysis indicated a positive and straight association between iron concentrations and risk of breast cancer but because of high heterogeneity we recommend more accurate future studies |
| first_indexed | 2024-12-11T17:01:17Z |
| format | Article |
| id | doaj.art-e6f2dedf3adc4fcca54f72b24ece973a |
| institution | Directory Open Access Journal |
| issn | 2008-6164 2008-6172 |
| language | English |
| last_indexed | 2024-12-11T17:01:17Z |
| publishDate | 2020-01-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj.art-e6f2dedf3adc4fcca54f72b24ece973a2022-12-22T00:57:50ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722020-01-01111111A systematic review and meta-analysis on the association of serum and tumor tissue iron and risk of breast cancerAkram Sanagoo0Faezeh Kiani1Marzieh Saei Gharenaz2Fatemeh Sayehmiri3Fatemeh koohi4Leila Jouybari5Majid Dousti6 Nursing Research Center, Golestan University of Medical Sciences, Gorgan, Iran Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran Students Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran Student Research Committee, Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran Nursing Research Center, Golestan University of Medical Sciences, Gorgan, Iran Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Background: Some studies have investigated the effects of iron on breast carcinogenesis and reported different findings about the association between Fe and breast cancer risk. This study was conducted to estimate this effect using meta-analysis method. Methods: A total of 20 articles published between 1984 and 2017 worldwide were selected through searching PubMed, Scopus, Embase, Web of Science, and Cochrane Library. Keywords such Breast Cancer, Neoplasm, Trace elements, Iron, Breast tissue concentration, Plasma concentration, Scalp hair concentration, toenail concentration and their combination were used in the search. Results: The total number of participants was 4,110 individuals comprising 1,624 patients with breast cancer and 2,486 healthy subjects. Fe concentration was measured in the various subgroups in both case and control groups. There were significant correlations between Fe concentration and breast cancer in breast tissue subgroup (SMD: 0.67 [95% CI: 0.17 to 1.17; P=0.009]). Whereas, there was no meaningful difference in Fe status between women with and without breast cancer related to scalp hair and plasma subgroups; (SMD: -3.74 [95% CI: -7.58 to 0.10; P=0.056] and (SMD:-1.14[95% CI: -2.30 to 0.03; P=0.055], respectively. Conclusion: The present meta-analysis indicated a positive and straight association between iron concentrations and risk of breast cancer but because of high heterogeneity we recommend more accurate future studieshttp://caspjim.com/article-1-1674-en.htmlbreast cancertrace elementsironmeta-analysis. |
| spellingShingle | Akram Sanagoo Faezeh Kiani Marzieh Saei Gharenaz Fatemeh Sayehmiri Fatemeh koohi Leila Jouybari Majid Dousti A systematic review and meta-analysis on the association of serum and tumor tissue iron and risk of breast cancer Caspian Journal of Internal Medicine breast cancer trace elements iron meta-analysis. |
| title | A systematic review and meta-analysis on the association of serum and tumor tissue iron and risk of breast cancer |
| title_full | A systematic review and meta-analysis on the association of serum and tumor tissue iron and risk of breast cancer |
| title_fullStr | A systematic review and meta-analysis on the association of serum and tumor tissue iron and risk of breast cancer |
| title_full_unstemmed | A systematic review and meta-analysis on the association of serum and tumor tissue iron and risk of breast cancer |
| title_short | A systematic review and meta-analysis on the association of serum and tumor tissue iron and risk of breast cancer |
| title_sort | systematic review and meta analysis on the association of serum and tumor tissue iron and risk of breast cancer |
| topic | breast cancer trace elements iron meta-analysis. |
| url | http://caspjim.com/article-1-1674-en.html |
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