N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody

N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody

Summary: N4-hydroxycytidine (NHC), the active compound of the drug Molnupiravir, is incorporated into SARS-CoV-2 RNA, causing false base pairing. The desired result is an “error catastrophe,” but this bears the risk of mutated virus progeny. To address this experimentally, we propagated the initial...

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Bibliographic Details
Main Authors: Arne Zibat, Xiaoxiao Zhang, Antje Dickmanns, Kim M. Stegmann, Adrian W. Dobbelstein, Halima Alachram, Rebecca Soliwoda, Gabriela Salinas, Uwe Groß, Dirk Görlich, Maik Kschischo, Bernd Wollnik, Matthias Dobbelstein
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Pharmaceutical science
Immunology
Virology
Structural biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223018631

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223018631

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