Lipiodol retention pattern after TACE for HCC is a predictor for local progression in lesions with complete response
Abstract Background To evaluate the predictive value of the lipiodol retention pattern for local progression of HCC with a complete response (CR) on CT according to mRECIST criteria after a first session of conventional chemoembolization (cTACE). Methods From January 2014 to May 2016 all consecutive...
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | Cancer Imaging |
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| Online Access: | http://link.springer.com/article/10.1186/s40644-019-0260-2 |
| _version_ | 1818614864712564736 |
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| author | Marco Dioguardi Burgio Riccardo Sartoris Claudia Libotean Magaly Zappa Annie Sibert Valérie Vilgrain Maxime Ronot |
| author_facet | Marco Dioguardi Burgio Riccardo Sartoris Claudia Libotean Magaly Zappa Annie Sibert Valérie Vilgrain Maxime Ronot |
| author_sort | Marco Dioguardi Burgio |
| collection | DOAJ |
| description | Abstract Background To evaluate the predictive value of the lipiodol retention pattern for local progression of HCC with a complete response (CR) on CT according to mRECIST criteria after a first session of conventional chemoembolization (cTACE). Methods From January 2014 to May 2016 all consecutive patients undergoing a first cTACE session for HCC were identified. Inclusion criteria were the presence of ≤3 HCCs and available pre- and post-cTACE CT. Tumor response was classified according to mRECIST criteria. The analysis focused on tumors with a CR. The lipiodol retention pattern in these tumors was classified as complete (C-Lip, covering the entire tumor volume), or incomplete (I-Lip). Local progression was defined as the reappearance of areas of enhancement on arterial-phase images with washout on portal/delayed phase images within 2 cm from treated tumors on follow-up CT. Results The final population included 50 patients with 82 HCCs. A total of 46 (56%) HCCs were classified with a CR, including 16 (35%) with I-Lip, and 30 (65%) with C-Lip. After a median follow-up of 14 months (3.2–35.9 months), 15/16 (94%) and 10/30 (30%) of I-Lip and C-Lip HCCs showed local progression on CT, respectively (p < 0.001), with no significant difference in the time to progression (mean 11.1 ± 2 vs. 13.4 ± 3 months for I-Lip and C-Lip, respectively p = 0.51). Conclusions HCCs with incomplete lipiodol retention after a first cTACE session have a high risk of local progression even when there is a CR according to mRECIST, and should be considered to be incompletely treated. |
| first_indexed | 2024-12-16T16:24:47Z |
| format | Article |
| id | doaj.art-e6f54bac0d2a40daa668cce9cfa4c726 |
| institution | Directory Open Access Journal |
| issn | 1470-7330 |
| language | English |
| last_indexed | 2024-12-16T16:24:47Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj.art-e6f54bac0d2a40daa668cce9cfa4c7262022-12-21T22:24:47ZengBMCCancer Imaging1470-73302019-11-011911910.1186/s40644-019-0260-2Lipiodol retention pattern after TACE for HCC is a predictor for local progression in lesions with complete responseMarco Dioguardi Burgio0Riccardo Sartoris1Claudia Libotean2Magaly Zappa3Annie Sibert4Valérie Vilgrain5Maxime Ronot6Department of Radiology, APHP, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-SeineDepartment of Radiology, APHP, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-SeineDepartment of Radiology, APHP, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-SeineDepartment of Radiology, APHP, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-SeineDepartment of Radiology, APHP, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-SeineDepartment of Radiology, APHP, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-SeineDepartment of Radiology, APHP, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-SeineAbstract Background To evaluate the predictive value of the lipiodol retention pattern for local progression of HCC with a complete response (CR) on CT according to mRECIST criteria after a first session of conventional chemoembolization (cTACE). Methods From January 2014 to May 2016 all consecutive patients undergoing a first cTACE session for HCC were identified. Inclusion criteria were the presence of ≤3 HCCs and available pre- and post-cTACE CT. Tumor response was classified according to mRECIST criteria. The analysis focused on tumors with a CR. The lipiodol retention pattern in these tumors was classified as complete (C-Lip, covering the entire tumor volume), or incomplete (I-Lip). Local progression was defined as the reappearance of areas of enhancement on arterial-phase images with washout on portal/delayed phase images within 2 cm from treated tumors on follow-up CT. Results The final population included 50 patients with 82 HCCs. A total of 46 (56%) HCCs were classified with a CR, including 16 (35%) with I-Lip, and 30 (65%) with C-Lip. After a median follow-up of 14 months (3.2–35.9 months), 15/16 (94%) and 10/30 (30%) of I-Lip and C-Lip HCCs showed local progression on CT, respectively (p < 0.001), with no significant difference in the time to progression (mean 11.1 ± 2 vs. 13.4 ± 3 months for I-Lip and C-Lip, respectively p = 0.51). Conclusions HCCs with incomplete lipiodol retention after a first cTACE session have a high risk of local progression even when there is a CR according to mRECIST, and should be considered to be incompletely treated.http://link.springer.com/article/10.1186/s40644-019-0260-2Carcinoma, hepatocellularEthiodized oilChemoembolization, therapeutic |
| spellingShingle | Marco Dioguardi Burgio Riccardo Sartoris Claudia Libotean Magaly Zappa Annie Sibert Valérie Vilgrain Maxime Ronot Lipiodol retention pattern after TACE for HCC is a predictor for local progression in lesions with complete response Cancer Imaging Carcinoma, hepatocellular Ethiodized oil Chemoembolization, therapeutic |
| title | Lipiodol retention pattern after TACE for HCC is a predictor for local progression in lesions with complete response |
| title_full | Lipiodol retention pattern after TACE for HCC is a predictor for local progression in lesions with complete response |
| title_fullStr | Lipiodol retention pattern after TACE for HCC is a predictor for local progression in lesions with complete response |
| title_full_unstemmed | Lipiodol retention pattern after TACE for HCC is a predictor for local progression in lesions with complete response |
| title_short | Lipiodol retention pattern after TACE for HCC is a predictor for local progression in lesions with complete response |
| title_sort | lipiodol retention pattern after tace for hcc is a predictor for local progression in lesions with complete response |
| topic | Carcinoma, hepatocellular Ethiodized oil Chemoembolization, therapeutic |
| url | http://link.springer.com/article/10.1186/s40644-019-0260-2 |
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