Recent Advances of Pharmaceutical Process Chemistry and Its Innovation in China: Part 1

This review article summarizes recent developments and innovations in China's pharmaceutical process chemistry over the last several decades. Case studies of dozens of blockbuster drug processes are presented, including bulk drugs, such as the over-the-counter medicine biotin, demonstrating Chi...

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Main Authors: Pei Tang, Biao Nie, Jiuzhong Huang, Yingjun Zhang, Ji Zhang, Fen-er Chen
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2020-03-01
Series:Pharmaceutical Fronts
Subjects:
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1701652
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author Pei Tang
Biao Nie
Jiuzhong Huang
Yingjun Zhang
Ji Zhang
Fen-er Chen
author_facet Pei Tang
Biao Nie
Jiuzhong Huang
Yingjun Zhang
Ji Zhang
Fen-er Chen
author_sort Pei Tang
collection DOAJ
description This review article summarizes recent developments and innovations in China's pharmaceutical process chemistry over the last several decades. Case studies of dozens of blockbuster drug processes are presented, including bulk drugs, such as the over-the-counter medicine biotin, demonstrating China's substantial effort to green its pharmaceutical processes. Owing to the increasing stringent environmental regulations, Chinese chemists have invented several cutting-edge and eco-friendly synthetic methods that are beneficial to environmental protection. Applied to large-scale industrial production, these processes have a greatly reduced environmental footprint, promoting the sustainable development of global economy and health.
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spelling doaj.art-e6f7485fd00c400d95ce245c634ebeb72022-12-21T22:55:53ZengGeorg Thieme Verlag KGPharmaceutical Fronts2628-50882628-50962020-03-010201e28e5410.1055/s-0040-1701652Recent Advances of Pharmaceutical Process Chemistry and Its Innovation in China: Part 1Pei Tang0Biao Nie1Jiuzhong Huang2Yingjun Zhang3Ji Zhang4Fen-er Chen5Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, ChinaHEC Pharm Group, HEC R&D Center, Guangdong, People's Republic of ChinaHEC Pharm Group, HEC R&D Center, Guangdong, People's Republic of ChinaHEC Pharm Group, HEC R&D Center, Guangdong, People's Republic of ChinaHEC Pharm Group, HEC R&D Center, Guangdong, People's Republic of ChinaSichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, ChinaThis review article summarizes recent developments and innovations in China's pharmaceutical process chemistry over the last several decades. Case studies of dozens of blockbuster drug processes are presented, including bulk drugs, such as the over-the-counter medicine biotin, demonstrating China's substantial effort to green its pharmaceutical processes. Owing to the increasing stringent environmental regulations, Chinese chemists have invented several cutting-edge and eco-friendly synthetic methods that are beneficial to environmental protection. Applied to large-scale industrial production, these processes have a greatly reduced environmental footprint, promoting the sustainable development of global economy and health.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1701652pharmaceutical industrygreen processasymmetric catalysischiral drugsstereoselectivity
spellingShingle Pei Tang
Biao Nie
Jiuzhong Huang
Yingjun Zhang
Ji Zhang
Fen-er Chen
Recent Advances of Pharmaceutical Process Chemistry and Its Innovation in China: Part 1
Pharmaceutical Fronts
pharmaceutical industry
green process
asymmetric catalysis
chiral drugs
stereoselectivity
title Recent Advances of Pharmaceutical Process Chemistry and Its Innovation in China: Part 1
title_full Recent Advances of Pharmaceutical Process Chemistry and Its Innovation in China: Part 1
title_fullStr Recent Advances of Pharmaceutical Process Chemistry and Its Innovation in China: Part 1
title_full_unstemmed Recent Advances of Pharmaceutical Process Chemistry and Its Innovation in China: Part 1
title_short Recent Advances of Pharmaceutical Process Chemistry and Its Innovation in China: Part 1
title_sort recent advances of pharmaceutical process chemistry and its innovation in china part 1
topic pharmaceutical industry
green process
asymmetric catalysis
chiral drugs
stereoselectivity
url http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1701652
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