Low plasma vitamin D is associated with increased 28-day mortality and worse clinical outcomes in critically ill patients
Abstract Background & objective Patients in the intensive care unit have a high prevalence of vitamin D deficiency (VDD). In the present study, clinical outcomes in the ICU were analyzed with vitamin D status. Materials and methods In this prospective, multicenter study, sampling was conducted o...
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BMC
2024-01-01
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| Series: | BMC Nutrition |
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| Online Access: | https://doi.org/10.1186/s40795-023-00801-1 |
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| author | Fatemeh Sistanian Alireza Sedaghat Mohaddeseh Badpeyma Majid Khadem Rezaiyan Ahmad Bagheri Moghaddam Golnaz Ranjbar Mostafa Arabi Mohammad Bagherniya Abdolreza Norouzy |
| author_facet | Fatemeh Sistanian Alireza Sedaghat Mohaddeseh Badpeyma Majid Khadem Rezaiyan Ahmad Bagheri Moghaddam Golnaz Ranjbar Mostafa Arabi Mohammad Bagherniya Abdolreza Norouzy |
| author_sort | Fatemeh Sistanian |
| collection | DOAJ |
| description | Abstract Background & objective Patients in the intensive care unit have a high prevalence of vitamin D deficiency (VDD). In the present study, clinical outcomes in the ICU were analyzed with vitamin D status. Materials and methods In this prospective, multicenter study, sampling was conducted on seven ICUs in three hospitals. Within the first 24 h of ICU admission, patient’s serum vitamin D levels were measured, and their disease severity was monitored using the scores of acute physiologic assessment and chronic health evaluation II (APACHE II), sequential organ failure assessment (SOFA), and the modified Nutrition Risk in Critically ill (mNUTRIC) score. Results A total of 236 patients were enrolled in this study, of which 163 (69.1%) had lower vitamin D levels than 20 ng/ml upon ICU admission. The patients with VDD had higher APACHE II scores)P = 0.02), SOFA scores (P < 0.001), and mNUTRIC scores (P = 0.01). Patients with sufficient levels of vitamin D (> 30 ng/ml) had a shorter stay at ICU (P < 0.001). VDD was independently associated with 28-day mortality (OR: 4.83; 95% CI: 1.63–14.27; P = 0.004). Conclusion The data showed that VDD was common among the critically ill and was related to a more severe course of illness and a higher mortality rate. |
| first_indexed | 2024-03-08T14:18:38Z |
| format | Article |
| id | doaj.art-e6f915aaeb7f48eb8bb3f40da8614c8f |
| institution | Directory Open Access Journal |
| issn | 2055-0928 |
| language | English |
| last_indexed | 2024-03-08T14:18:38Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nutrition |
| spelling | doaj.art-e6f915aaeb7f48eb8bb3f40da8614c8f2024-01-14T12:15:00ZengBMCBMC Nutrition2055-09282024-01-011011810.1186/s40795-023-00801-1Low plasma vitamin D is associated with increased 28-day mortality and worse clinical outcomes in critically ill patientsFatemeh Sistanian0Alireza Sedaghat1Mohaddeseh Badpeyma2Majid Khadem Rezaiyan3Ahmad Bagheri Moghaddam4Golnaz Ranjbar5Mostafa Arabi6Mohammad Bagherniya7Abdolreza Norouzy8Department of Nutrition, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Anesthesiology, Faculty of Medicine, Lung Diseases Research Center, Mashhad University of Medical ScienceStudent Research Committee, Tabriz University of Medical SciencesDepartment of Community Medicine, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Anesthesiology, Faculty of Medicine, Lung Diseases Research Center, Mashhad University of Medical ScienceDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Basic Sciences, School of Medicine, Neyshabur University of Medical SciencesNutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical SciencesAbstract Background & objective Patients in the intensive care unit have a high prevalence of vitamin D deficiency (VDD). In the present study, clinical outcomes in the ICU were analyzed with vitamin D status. Materials and methods In this prospective, multicenter study, sampling was conducted on seven ICUs in three hospitals. Within the first 24 h of ICU admission, patient’s serum vitamin D levels were measured, and their disease severity was monitored using the scores of acute physiologic assessment and chronic health evaluation II (APACHE II), sequential organ failure assessment (SOFA), and the modified Nutrition Risk in Critically ill (mNUTRIC) score. Results A total of 236 patients were enrolled in this study, of which 163 (69.1%) had lower vitamin D levels than 20 ng/ml upon ICU admission. The patients with VDD had higher APACHE II scores)P = 0.02), SOFA scores (P < 0.001), and mNUTRIC scores (P = 0.01). Patients with sufficient levels of vitamin D (> 30 ng/ml) had a shorter stay at ICU (P < 0.001). VDD was independently associated with 28-day mortality (OR: 4.83; 95% CI: 1.63–14.27; P = 0.004). Conclusion The data showed that VDD was common among the critically ill and was related to a more severe course of illness and a higher mortality rate.https://doi.org/10.1186/s40795-023-00801-1Critically Ill patientsVitamin D DeficiencyIntensive care unitMortalityVitamin D |
| spellingShingle | Fatemeh Sistanian Alireza Sedaghat Mohaddeseh Badpeyma Majid Khadem Rezaiyan Ahmad Bagheri Moghaddam Golnaz Ranjbar Mostafa Arabi Mohammad Bagherniya Abdolreza Norouzy Low plasma vitamin D is associated with increased 28-day mortality and worse clinical outcomes in critically ill patients BMC Nutrition Critically Ill patients Vitamin D Deficiency Intensive care unit Mortality Vitamin D |
| title | Low plasma vitamin D is associated with increased 28-day mortality and worse clinical outcomes in critically ill patients |
| title_full | Low plasma vitamin D is associated with increased 28-day mortality and worse clinical outcomes in critically ill patients |
| title_fullStr | Low plasma vitamin D is associated with increased 28-day mortality and worse clinical outcomes in critically ill patients |
| title_full_unstemmed | Low plasma vitamin D is associated with increased 28-day mortality and worse clinical outcomes in critically ill patients |
| title_short | Low plasma vitamin D is associated with increased 28-day mortality and worse clinical outcomes in critically ill patients |
| title_sort | low plasma vitamin d is associated with increased 28 day mortality and worse clinical outcomes in critically ill patients |
| topic | Critically Ill patients Vitamin D Deficiency Intensive care unit Mortality Vitamin D |
| url | https://doi.org/10.1186/s40795-023-00801-1 |
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