Heat the Clock: Entrainment and Compensation in 'Arabidopsis' Circadian Rhythms
The circadian clock is a biological mechanism that permits some organisms to anticipate daily environmental variations. This clock generates biological rhythms, which can be reset by environmental cues such as cycles of light or temperature, a process known as entrainment. After entrainment, circadi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ubiquity Press
2019-05-01
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| Series: | Journal of Circadian Rhythms |
| Subjects: | |
| Online Access: | https://www.jcircadianrhythms.com/articles/179 |
| _version_ | 1828467916619644928 |
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| author | Paula A. Avello Seth J. Davis James Ronald Jonathan W. Pitchford |
| author_facet | Paula A. Avello Seth J. Davis James Ronald Jonathan W. Pitchford |
| author_sort | Paula A. Avello |
| collection | DOAJ |
| description | The circadian clock is a biological mechanism that permits some organisms to anticipate daily environmental variations. This clock generates biological rhythms, which can be reset by environmental cues such as cycles of light or temperature, a process known as entrainment. After entrainment, circadian rhythms typically persist with approximately 24 hours periodicity in free-running conditions, 'i.e'. in the absence of environmental cues. Experimental evidence also shows that a free-running period close to 24 hours is maintained across a range of temperatures, a process known as temperature compensation. In the plant 'Arabidopsis', the effect of light on the circadian system has been widely studied and successfully modelled mathematically. However, the role of temperature in periodicity, and the relationship between entrainment and compensation, are not fully understood. Here we adapt recent models to incorporate temperature dependence by applying Arrhenius equations to the parameters of the models that characterize transcription, translation, and degradation rates. We show that the resulting models can exhibit thermal entrainment and temperature compensation, but that these phenomena emerge from physiologically different sets of processes. Further simulations combining thermal and photic forcing in more realistic scenarios clearly distinguish between the processes of entrainment and compensation, and reveal temperature compensation as an emergent property which can arise as a result of multiple temperature-dependent interactions. Our results consistently point to the thermal sensitivity of degradation rates as driving compensation and entrainment across a range of conditions. |
| first_indexed | 2024-12-11T04:14:58Z |
| format | Article |
| id | doaj.art-e6f9fbf117cc4ee4bb3d20f07e2eed82 |
| institution | Directory Open Access Journal |
| issn | 1740-3391 |
| language | English |
| last_indexed | 2024-12-11T04:14:58Z |
| publishDate | 2019-05-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Journal of Circadian Rhythms |
| spelling | doaj.art-e6f9fbf117cc4ee4bb3d20f07e2eed822022-12-22T01:21:17ZengUbiquity PressJournal of Circadian Rhythms1740-33912019-05-0117110.5334/jcr.179156Heat the Clock: Entrainment and Compensation in 'Arabidopsis' Circadian RhythmsPaula A. Avello0Seth J. Davis1James Ronald2Jonathan W. Pitchford3Department of Mathematics, University of YorkDepartment of Biology, University of YorkDepartment of Biology, University of YorkDepartment of Mathematics, University of York; Department of Biology, University of YorkThe circadian clock is a biological mechanism that permits some organisms to anticipate daily environmental variations. This clock generates biological rhythms, which can be reset by environmental cues such as cycles of light or temperature, a process known as entrainment. After entrainment, circadian rhythms typically persist with approximately 24 hours periodicity in free-running conditions, 'i.e'. in the absence of environmental cues. Experimental evidence also shows that a free-running period close to 24 hours is maintained across a range of temperatures, a process known as temperature compensation. In the plant 'Arabidopsis', the effect of light on the circadian system has been widely studied and successfully modelled mathematically. However, the role of temperature in periodicity, and the relationship between entrainment and compensation, are not fully understood. Here we adapt recent models to incorporate temperature dependence by applying Arrhenius equations to the parameters of the models that characterize transcription, translation, and degradation rates. We show that the resulting models can exhibit thermal entrainment and temperature compensation, but that these phenomena emerge from physiologically different sets of processes. Further simulations combining thermal and photic forcing in more realistic scenarios clearly distinguish between the processes of entrainment and compensation, and reveal temperature compensation as an emergent property which can arise as a result of multiple temperature-dependent interactions. Our results consistently point to the thermal sensitivity of degradation rates as driving compensation and entrainment across a range of conditions.https://www.jcircadianrhythms.com/articles/179circadian clockmathematical modellingtemperature entrainmenttemperature compensationdiurnal temperature range |
| spellingShingle | Paula A. Avello Seth J. Davis James Ronald Jonathan W. Pitchford Heat the Clock: Entrainment and Compensation in 'Arabidopsis' Circadian Rhythms Journal of Circadian Rhythms circadian clock mathematical modelling temperature entrainment temperature compensation diurnal temperature range |
| title | Heat the Clock: Entrainment and Compensation in 'Arabidopsis' Circadian Rhythms |
| title_full | Heat the Clock: Entrainment and Compensation in 'Arabidopsis' Circadian Rhythms |
| title_fullStr | Heat the Clock: Entrainment and Compensation in 'Arabidopsis' Circadian Rhythms |
| title_full_unstemmed | Heat the Clock: Entrainment and Compensation in 'Arabidopsis' Circadian Rhythms |
| title_short | Heat the Clock: Entrainment and Compensation in 'Arabidopsis' Circadian Rhythms |
| title_sort | heat the clock entrainment and compensation in arabidopsis circadian rhythms |
| topic | circadian clock mathematical modelling temperature entrainment temperature compensation diurnal temperature range |
| url | https://www.jcircadianrhythms.com/articles/179 |
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