Promises of targeted therapy for low grade gliomas in children
Low grade gliomas are the most common brain tumors in children. Total resection for operable lesion helps to achieve local and system control. Nevertheless, for inaccessible tumors are required more effective treatment both to overcome the refractory course of the disease, and to mi nimize toxicity...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2019-07-01
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| Series: | Успехи молекулярной онкологии |
| Subjects: | |
| Online Access: | https://umo.abvpress.ru/jour/article/view/216 |
| _version_ | 1797700196953489408 |
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| author | E. F. Valiakhmetova L. A. Yasko L. I. Papusha A. E. Druy A. I. Karachunsky |
| author_facet | E. F. Valiakhmetova L. A. Yasko L. I. Papusha A. E. Druy A. I. Karachunsky |
| author_sort | E. F. Valiakhmetova |
| collection | DOAJ |
| description | Low grade gliomas are the most common brain tumors in children. Total resection for operable lesion helps to achieve local and system control. Nevertheless, for inaccessible tumors are required more effective treatment both to overcome the refractory course of the disease, and to mi nimize toxicity with conventional adjuvant chemotherapy and various types of radiation therapy. In recent years, there has been an accelerated understanding of the molecular pathogenesis of some tumors in children, including low grade gliomas. Given the fact that the basis of the molecular pathogenesis of the low grade gliomas is the activation of signaling pathways MARK (mitogen activated protein kinase) and mTOR (mammalian target of rapamycin), the most promising targeted agents are BRAF, MEK and mTOR inhibitors. Nevertheless, a number of other agents have been studied to find promising targeted therapy for this tumors type. This article summarizes the latest literature evaluating new drugs in low grade glioma. |
| first_indexed | 2024-03-12T04:18:29Z |
| format | Article |
| id | doaj.art-e6fae0a208404fa4b979278f2b3c1205 |
| institution | Directory Open Access Journal |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| last_indexed | 2024-03-12T04:18:29Z |
| publishDate | 2019-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj.art-e6fae0a208404fa4b979278f2b3c12052023-09-03T10:34:41ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872019-07-0162284110.17650/2313-805X-2019-6-2-28-41160Promises of targeted therapy for low grade gliomas in childrenE. F. Valiakhmetova0L. A. Yasko1L. I. Papusha2A. E. Druy3A. I. Karachunsky4ФГАУ «Национальный медицинский исследовательский центр нейрохирургии им. акад. Н. Н. Бурденко» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России; ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова» Минздрава РоссииLow grade gliomas are the most common brain tumors in children. Total resection for operable lesion helps to achieve local and system control. Nevertheless, for inaccessible tumors are required more effective treatment both to overcome the refractory course of the disease, and to mi nimize toxicity with conventional adjuvant chemotherapy and various types of radiation therapy. In recent years, there has been an accelerated understanding of the molecular pathogenesis of some tumors in children, including low grade gliomas. Given the fact that the basis of the molecular pathogenesis of the low grade gliomas is the activation of signaling pathways MARK (mitogen activated protein kinase) and mTOR (mammalian target of rapamycin), the most promising targeted agents are BRAF, MEK and mTOR inhibitors. Nevertheless, a number of other agents have been studied to find promising targeted therapy for this tumors type. This article summarizes the latest literature evaluating new drugs in low grade glioma.https://umo.abvpress.ru/jour/article/view/216глиома низкой степени злокачественноститаргетная терапияслияние braf:kiaa1549мутация brafv600субэпендимальная гигантоклеточная астроцитомаmtorингибитор тирозинкиназы |
| spellingShingle | E. F. Valiakhmetova L. A. Yasko L. I. Papusha A. E. Druy A. I. Karachunsky Promises of targeted therapy for low grade gliomas in children Успехи молекулярной онкологии глиома низкой степени злокачественности таргетная терапия слияние braf:kiaa1549 мутация brafv600 субэпендимальная гигантоклеточная астроцитома mtor ингибитор тирозинкиназы |
| title | Promises of targeted therapy for low grade gliomas in children |
| title_full | Promises of targeted therapy for low grade gliomas in children |
| title_fullStr | Promises of targeted therapy for low grade gliomas in children |
| title_full_unstemmed | Promises of targeted therapy for low grade gliomas in children |
| title_short | Promises of targeted therapy for low grade gliomas in children |
| title_sort | promises of targeted therapy for low grade gliomas in children |
| topic | глиома низкой степени злокачественности таргетная терапия слияние braf:kiaa1549 мутация brafv600 субэпендимальная гигантоклеточная астроцитома mtor ингибитор тирозинкиназы |
| url | https://umo.abvpress.ru/jour/article/view/216 |
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