Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review
Abstract Twenty to thirty percent of psoriasis (Pso) patients will develop psoriatic arthritis (PsA). Detection of Pso patients that are (at risk for) developing PsA is essential to prevent structural damage. We conducted a systematic search of five bibliographic databases, up to May 2020. We search...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13075-021-02545-4 |
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| author | Michelle L. M. Mulder Tamara W. van Hal Mark H. Wenink Hans J. P. M. Koenen Frank H. J. van den Hoogen Elke M. G. J. de Jong Juul M. P. A. van den Reek Johanna E. Vriezekolk |
| author_facet | Michelle L. M. Mulder Tamara W. van Hal Mark H. Wenink Hans J. P. M. Koenen Frank H. J. van den Hoogen Elke M. G. J. de Jong Juul M. P. A. van den Reek Johanna E. Vriezekolk |
| author_sort | Michelle L. M. Mulder |
| collection | DOAJ |
| description | Abstract Twenty to thirty percent of psoriasis (Pso) patients will develop psoriatic arthritis (PsA). Detection of Pso patients that are (at risk for) developing PsA is essential to prevent structural damage. We conducted a systematic search of five bibliographic databases, up to May 2020. We searched for studies assessing markers (clinical, laboratory, genetic) associated with the development or presence of PsA in Pso patients. Study selection and quality assessment of the included studies was performed, followed by a qualitative best evidence synthesis to determine the level of evidence for a marker and its association with concomitant/developing PsA in Pso. Overall, 259 possible markers were identified in 119 studies that met the inclusion criteria. Laboratory markers related to inflammation and bone metabolism reached a strong level of evidence for the association (not prediction) of PsA in Pso. Only CXCL10 showed strong evidence for a positive predictive value for PsA in Pso. The importance of timely detecting PsA in a Pso population, and finding more (bio)markers contributing to early detection, remains high. |
| first_indexed | 2024-12-17T06:47:32Z |
| format | Article |
| id | doaj.art-e6fc5ebba49a41f6b2b072fcc29b0aec |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-12-17T06:47:32Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-e6fc5ebba49a41f6b2b072fcc29b0aec2022-12-21T21:59:42ZengBMCArthritis Research & Therapy1478-63622021-06-0123112210.1186/s13075-021-02545-4Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic reviewMichelle L. M. Mulder0Tamara W. van Hal1Mark H. Wenink2Hans J. P. M. Koenen3Frank H. J. van den Hoogen4Elke M. G. J. de Jong5Juul M. P. A. van den Reek6Johanna E. Vriezekolk7Department of Rheumatology, Sint MaartenskliniekDepartment of Rheumatology, Sint MaartenskliniekDepartment of Rheumatology, Sint MaartenskliniekLaboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Medical CenterRadboud UniversityRadboud Institute for Health Sciences (RIHS), Radboud University Medical CenterRadboud Institute for Health Sciences (RIHS), Radboud University Medical CenterDepartment of Rheumatology, Sint MaartenskliniekAbstract Twenty to thirty percent of psoriasis (Pso) patients will develop psoriatic arthritis (PsA). Detection of Pso patients that are (at risk for) developing PsA is essential to prevent structural damage. We conducted a systematic search of five bibliographic databases, up to May 2020. We searched for studies assessing markers (clinical, laboratory, genetic) associated with the development or presence of PsA in Pso patients. Study selection and quality assessment of the included studies was performed, followed by a qualitative best evidence synthesis to determine the level of evidence for a marker and its association with concomitant/developing PsA in Pso. Overall, 259 possible markers were identified in 119 studies that met the inclusion criteria. Laboratory markers related to inflammation and bone metabolism reached a strong level of evidence for the association (not prediction) of PsA in Pso. Only CXCL10 showed strong evidence for a positive predictive value for PsA in Pso. The importance of timely detecting PsA in a Pso population, and finding more (bio)markers contributing to early detection, remains high.https://doi.org/10.1186/s13075-021-02545-4PsoriasisPsoriatic arthritisSystematic review(Bio)markerScreeningClinical |
| spellingShingle | Michelle L. M. Mulder Tamara W. van Hal Mark H. Wenink Hans J. P. M. Koenen Frank H. J. van den Hoogen Elke M. G. J. de Jong Juul M. P. A. van den Reek Johanna E. Vriezekolk Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review Arthritis Research & Therapy Psoriasis Psoriatic arthritis Systematic review (Bio)marker Screening Clinical |
| title | Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review |
| title_full | Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review |
| title_fullStr | Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review |
| title_full_unstemmed | Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review |
| title_short | Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review |
| title_sort | clinical laboratory and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients a systematic review |
| topic | Psoriasis Psoriatic arthritis Systematic review (Bio)marker Screening Clinical |
| url | https://doi.org/10.1186/s13075-021-02545-4 |
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