Engineered EGCG‐Containing Biomimetic Nanoassemblies as Effective Delivery Platform for Enhanced Cancer Therapy
Abstract Nano‐based immunotherapy of therapeutic biomolecules is attractive but tremendously hampered by the poor delivery efficiency. This study reports a novel delivery system of fluorinated‐coordinative‐epigallocatechin gallate (EGCG), referring as FEGCG/Zn, through the integration of fluorinatio...
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| Format: | Article |
| Language: | English |
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Wiley
2022-05-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202105894 |
| _version_ | 1818554722397716480 |
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| author | Pengkai Wu Haitian Zhang Yin Yin Meiling Sun Shuai Mao Huihui Chen Yexuan Deng Shuai Chen Shuo Li Beicheng Sun |
| author_facet | Pengkai Wu Haitian Zhang Yin Yin Meiling Sun Shuai Mao Huihui Chen Yexuan Deng Shuai Chen Shuo Li Beicheng Sun |
| author_sort | Pengkai Wu |
| collection | DOAJ |
| description | Abstract Nano‐based immunotherapy of therapeutic biomolecules is attractive but tremendously hampered by the poor delivery efficiency. This study reports a novel delivery system of fluorinated‐coordinative‐epigallocatechin gallate (EGCG), referring as FEGCG/Zn, through the integration of fluorination and zinc ions (Zn2+) into EGCG. The robust therapeutics of FEGCG/Zn are measured in terms of the regulating effect on programmed cell death ligand 1 (PD‐L1), the effective delivery of diverse biomolecules, and the hitchhiking ability using living cells. Taking small interfering RNA of PD‐L1 (siPD‐L1) and erythrocytes as an example, the fabricated biomimetic system achieves excellent siPD‐L1 delivery and further improves siPD‐L1 accumulation in tumors. Finally, the combination of FEGCG/Zn and siPD‐L1 promotes antitumor immunotherapy through alleviation of T cells exhaustion by regulating PD‐L1 expression in tumor cells. The results demonstrate that FEGCG/Zn substantially regulates PD‐L1 expression and improves immune‐biomolecule delivery by forming biomimetic nanoassemblies, offering a versatile platform for cancer immunotherapy. |
| first_indexed | 2024-12-12T09:43:49Z |
| format | Article |
| id | doaj.art-e6fce42768d549d88e0f99001ffb0262 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-12T09:43:49Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-e6fce42768d549d88e0f99001ffb02622022-12-22T00:28:30ZengWileyAdvanced Science2198-38442022-05-01915n/an/a10.1002/advs.202105894Engineered EGCG‐Containing Biomimetic Nanoassemblies as Effective Delivery Platform for Enhanced Cancer TherapyPengkai Wu0Haitian Zhang1Yin Yin2Meiling Sun3Shuai Mao4Huihui Chen5Yexuan Deng6Shuai Chen7Shuo Li8Beicheng Sun9Department of Hepatobiliary Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing Jiangsu Province 210008 P. R. ChinaDepartment of Hepatobiliary Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing Jiangsu Province 210008 P. R. ChinaDepartment of Hepatobiliary Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing Jiangsu Province 210008 P. R. ChinaDepartment of Hepatobiliary Surgery Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu Province 210008 P. R. ChinaDepartment of Hepatobiliary Surgery Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu Province 210008 P. R. ChinaDepartment of Hepatobiliary Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing Jiangsu Province 210008 P. R. ChinaDepartment of Hepatobiliary Surgery Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu Province 210008 P. R. ChinaMOE Key Laboratory of Model Animal for Disease Study Department of Endocrinology Nanjing Drum Tower Hospital and Model Animal Research Center School of Medicine Nanjing University Nanjing 210008 P. R. ChinaDepartment of Gastroenterology The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu Province 210029 P. R. ChinaDepartment of Hepatobiliary Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing Jiangsu Province 210008 P. R. ChinaAbstract Nano‐based immunotherapy of therapeutic biomolecules is attractive but tremendously hampered by the poor delivery efficiency. This study reports a novel delivery system of fluorinated‐coordinative‐epigallocatechin gallate (EGCG), referring as FEGCG/Zn, through the integration of fluorination and zinc ions (Zn2+) into EGCG. The robust therapeutics of FEGCG/Zn are measured in terms of the regulating effect on programmed cell death ligand 1 (PD‐L1), the effective delivery of diverse biomolecules, and the hitchhiking ability using living cells. Taking small interfering RNA of PD‐L1 (siPD‐L1) and erythrocytes as an example, the fabricated biomimetic system achieves excellent siPD‐L1 delivery and further improves siPD‐L1 accumulation in tumors. Finally, the combination of FEGCG/Zn and siPD‐L1 promotes antitumor immunotherapy through alleviation of T cells exhaustion by regulating PD‐L1 expression in tumor cells. The results demonstrate that FEGCG/Zn substantially regulates PD‐L1 expression and improves immune‐biomolecule delivery by forming biomimetic nanoassemblies, offering a versatile platform for cancer immunotherapy.https://doi.org/10.1002/advs.202105894biomimetic deliverycoordinationEGCGfluorineimmunotherapy |
| spellingShingle | Pengkai Wu Haitian Zhang Yin Yin Meiling Sun Shuai Mao Huihui Chen Yexuan Deng Shuai Chen Shuo Li Beicheng Sun Engineered EGCG‐Containing Biomimetic Nanoassemblies as Effective Delivery Platform for Enhanced Cancer Therapy Advanced Science biomimetic delivery coordination EGCG fluorine immunotherapy |
| title | Engineered EGCG‐Containing Biomimetic Nanoassemblies as Effective Delivery Platform for Enhanced Cancer Therapy |
| title_full | Engineered EGCG‐Containing Biomimetic Nanoassemblies as Effective Delivery Platform for Enhanced Cancer Therapy |
| title_fullStr | Engineered EGCG‐Containing Biomimetic Nanoassemblies as Effective Delivery Platform for Enhanced Cancer Therapy |
| title_full_unstemmed | Engineered EGCG‐Containing Biomimetic Nanoassemblies as Effective Delivery Platform for Enhanced Cancer Therapy |
| title_short | Engineered EGCG‐Containing Biomimetic Nanoassemblies as Effective Delivery Platform for Enhanced Cancer Therapy |
| title_sort | engineered egcg containing biomimetic nanoassemblies as effective delivery platform for enhanced cancer therapy |
| topic | biomimetic delivery coordination EGCG fluorine immunotherapy |
| url | https://doi.org/10.1002/advs.202105894 |
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