The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil
In Guided Bone Regeneration (GBR) materials and techniques are essential to achieve the expected results. Thanks to their properties, blood clots induce bone healing, maturation, differentiation and organization. The preferred material to protect the clot in Guided Bone Regeneration is the titanium...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
|
| Series: | Materials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1996-1944/14/21/6642 |
| _version_ | 1797512182781444096 |
|---|---|
| author | Lucio Milillo Fabrizio Cinone Federico Lo Presti Dorina Lauritano Massimo Petruzzi |
| author_facet | Lucio Milillo Fabrizio Cinone Federico Lo Presti Dorina Lauritano Massimo Petruzzi |
| author_sort | Lucio Milillo |
| collection | DOAJ |
| description | In Guided Bone Regeneration (GBR) materials and techniques are essential to achieve the expected results. Thanks to their properties, blood clots induce bone healing, maturation, differentiation and organization. The preferred material to protect the clot in Guided Bone Regeneration is the titanium foil, as it can be shaped according to the bone defect. Furthermore, its exposition in the oral cavity does not impair the procedure. We report on five clinical cases in order to explain the management of blood clots in combination with titanium foil barriers in different clinical settings. Besides being the best choice to protect the clot, the titanium foil represents an excellent barrier that is useful in GBR due to its biocompatibility, handling, and mechanical strength properties. The clot alone is the best natural scaffold to obtain the ideal bone quality and avoid the persistence of not-resorbed granules of filler materials in the newly regenerated bone. Even though clot contraction still needs to be improved, as it impacts the volume of the regenerated bone, future studies in GBR should be inspired by the clot and its fundamental properties. |
| first_indexed | 2024-03-10T05:58:15Z |
| format | Article |
| id | doaj.art-e6ff38a4972a45dbb8b1577f00fdbb59 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T05:58:15Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-e6ff38a4972a45dbb8b1577f00fdbb592023-11-22T21:15:15ZengMDPI AGMaterials1996-19442021-11-011421664210.3390/ma14216642The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium FoilLucio Milillo0Fabrizio Cinone1Federico Lo Presti2Dorina Lauritano3Massimo Petruzzi4Independent Researcher, 70126 Bari, ItalyIndependent Researcher, 70126 Bari, ItalyB.L. Consulting S.A.S.-Schio-Vicenza, 36015 Schio, ItalyCentre of Neuroscience of Milan, Department of Medicine and Surgery, University of Milano-Bicocca, 20090 Monza, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70126 Bari, ItalyIn Guided Bone Regeneration (GBR) materials and techniques are essential to achieve the expected results. Thanks to their properties, blood clots induce bone healing, maturation, differentiation and organization. The preferred material to protect the clot in Guided Bone Regeneration is the titanium foil, as it can be shaped according to the bone defect. Furthermore, its exposition in the oral cavity does not impair the procedure. We report on five clinical cases in order to explain the management of blood clots in combination with titanium foil barriers in different clinical settings. Besides being the best choice to protect the clot, the titanium foil represents an excellent barrier that is useful in GBR due to its biocompatibility, handling, and mechanical strength properties. The clot alone is the best natural scaffold to obtain the ideal bone quality and avoid the persistence of not-resorbed granules of filler materials in the newly regenerated bone. Even though clot contraction still needs to be improved, as it impacts the volume of the regenerated bone, future studies in GBR should be inspired by the clot and its fundamental properties.https://www.mdpi.com/1996-1944/14/21/6642blood clottitanium foilbone augmentationguided bone regeneration |
| spellingShingle | Lucio Milillo Fabrizio Cinone Federico Lo Presti Dorina Lauritano Massimo Petruzzi The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil Materials blood clot titanium foil bone augmentation guided bone regeneration |
| title | The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil |
| title_full | The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil |
| title_fullStr | The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil |
| title_full_unstemmed | The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil |
| title_short | The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil |
| title_sort | role of blood clot in guided bone regeneration biological considerations and clinical applications with titanium foil |
| topic | blood clot titanium foil bone augmentation guided bone regeneration |
| url | https://www.mdpi.com/1996-1944/14/21/6642 |
| work_keys_str_mv | AT luciomilillo theroleofbloodclotinguidedboneregenerationbiologicalconsiderationsandclinicalapplicationswithtitaniumfoil AT fabriziocinone theroleofbloodclotinguidedboneregenerationbiologicalconsiderationsandclinicalapplicationswithtitaniumfoil AT federicolopresti theroleofbloodclotinguidedboneregenerationbiologicalconsiderationsandclinicalapplicationswithtitaniumfoil AT dorinalauritano theroleofbloodclotinguidedboneregenerationbiologicalconsiderationsandclinicalapplicationswithtitaniumfoil AT massimopetruzzi theroleofbloodclotinguidedboneregenerationbiologicalconsiderationsandclinicalapplicationswithtitaniumfoil AT luciomilillo roleofbloodclotinguidedboneregenerationbiologicalconsiderationsandclinicalapplicationswithtitaniumfoil AT fabriziocinone roleofbloodclotinguidedboneregenerationbiologicalconsiderationsandclinicalapplicationswithtitaniumfoil AT federicolopresti roleofbloodclotinguidedboneregenerationbiologicalconsiderationsandclinicalapplicationswithtitaniumfoil AT dorinalauritano roleofbloodclotinguidedboneregenerationbiologicalconsiderationsandclinicalapplicationswithtitaniumfoil AT massimopetruzzi roleofbloodclotinguidedboneregenerationbiologicalconsiderationsandclinicalapplicationswithtitaniumfoil |