Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering
Polydeoxyribonucleotides (PDRNs) are a family of DNA-derived drugs with a molecular weight ranging from 50 to 1500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many pre-clinical and clinical studies have demonstrated the wound healing and anti-inflammatory pro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/19/6/296 |
| _version_ | 1797533030652313600 |
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| author | Tae-Hee Kim Seong-Yeong Heo Gun-Woo Oh Soo-Jin Heo Won-Kyo Jung |
| author_facet | Tae-Hee Kim Seong-Yeong Heo Gun-Woo Oh Soo-Jin Heo Won-Kyo Jung |
| author_sort | Tae-Hee Kim |
| collection | DOAJ |
| description | Polydeoxyribonucleotides (PDRNs) are a family of DNA-derived drugs with a molecular weight ranging from 50 to 1500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many pre-clinical and clinical studies have demonstrated the wound healing and anti-inflammatory properties of PDRN, which are mediated by the activation of adenosine A<sub>2A</sub> receptor and salvage pathways, in addition to promoting osteoblast activity, collagen synthesis, and angiogenesis. In fact, PDRN is already marketed due to its therapeutic properties against various wound healing- and inflammation-related diseases. Therefore, this review assessed the most recent trends in marine organism-derived PDRN using the Google Scholar search engine. Further, we summarized the current applications and pharmacological properties of PDRN to serve as a reference for the development of novel PDRN-based technologies. |
| first_indexed | 2024-03-10T11:08:49Z |
| format | Article |
| id | doaj.art-e6ff6e7c88d045feba112899d23957a7 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T11:08:49Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-e6ff6e7c88d045feba112899d23957a72023-11-21T20:58:31ZengMDPI AGMarine Drugs1660-33972021-05-0119629610.3390/md19060296Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical EngineeringTae-Hee Kim0Seong-Yeong Heo1Gun-Woo Oh2Soo-Jin Heo3Won-Kyo Jung4Department of Biomedical Engineering and New-Senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan 48513, KoreaResearch Center for Marine Integrated Bionics Technology, Pukyong National University, Busan 48513, KoreaResearch Center for Marine Integrated Bionics Technology, Pukyong National University, Busan 48513, KoreaJeju Marine Research Center, Korea Institute of Ocean Science & Technology (KIOST), Jeju 63349, KoreaDepartment of Biomedical Engineering and New-Senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan 48513, KoreaPolydeoxyribonucleotides (PDRNs) are a family of DNA-derived drugs with a molecular weight ranging from 50 to 1500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many pre-clinical and clinical studies have demonstrated the wound healing and anti-inflammatory properties of PDRN, which are mediated by the activation of adenosine A<sub>2A</sub> receptor and salvage pathways, in addition to promoting osteoblast activity, collagen synthesis, and angiogenesis. In fact, PDRN is already marketed due to its therapeutic properties against various wound healing- and inflammation-related diseases. Therefore, this review assessed the most recent trends in marine organism-derived PDRN using the Google Scholar search engine. Further, we summarized the current applications and pharmacological properties of PDRN to serve as a reference for the development of novel PDRN-based technologies.https://www.mdpi.com/1660-3397/19/6/296marine organismspolydeoxyribonucleotidebiomedical engineering |
| spellingShingle | Tae-Hee Kim Seong-Yeong Heo Gun-Woo Oh Soo-Jin Heo Won-Kyo Jung Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering Marine Drugs marine organisms polydeoxyribonucleotide biomedical engineering |
| title | Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering |
| title_full | Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering |
| title_fullStr | Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering |
| title_full_unstemmed | Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering |
| title_short | Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering |
| title_sort | applications of marine organism derived polydeoxyribonucleotide its potential in biomedical engineering |
| topic | marine organisms polydeoxyribonucleotide biomedical engineering |
| url | https://www.mdpi.com/1660-3397/19/6/296 |
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