Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer
Human airways are continuously colonized by microaspiration of microbiota. Less is known about the presence, origin and composition of microbiota in the lung parenchyma. In a study of 13 patients undergoing surgery for peripheral lung cancer microbiota composition was comparatively evaluated in uppe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/6/794 |
| _version_ | 1827716199049330688 |
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| author | Lena Reinhold Andreas Möllering Sönke Wallis Emanuel Palade Kathrin Schäfer Daniel Drömann Jan Rupp Simon Graspeuntner Klaus Dalhoff |
| author_facet | Lena Reinhold Andreas Möllering Sönke Wallis Emanuel Palade Kathrin Schäfer Daniel Drömann Jan Rupp Simon Graspeuntner Klaus Dalhoff |
| author_sort | Lena Reinhold |
| collection | DOAJ |
| description | Human airways are continuously colonized by microaspiration of microbiota. Less is known about the presence, origin and composition of microbiota in the lung parenchyma. In a study of 13 patients undergoing surgery for peripheral lung cancer microbiota composition was comparatively evaluated in upper airway, lower airway and lung tissue samples using 16S rDNA analysis. Bacterial density decreased stepwise from upper to lower airways and tissue. On a taxonomic level upper and lower airway microbiota were similar whereas lung tissue showed marked dissimilarities compared to lower airways that may reflect different environmental conditions shaping local microbiota and host immunity. |
| first_indexed | 2024-03-10T19:35:10Z |
| format | Article |
| id | doaj.art-e70134cf25154421894fbfbe9ad12ff2 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T19:35:10Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-e70134cf25154421894fbfbe9ad12ff22023-11-20T01:47:25ZengMDPI AGMicroorganisms2076-26072020-05-018679410.3390/microorganisms8060794Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung CancerLena Reinhold0Andreas Möllering1Sönke Wallis2Emanuel Palade3Kathrin Schäfer4Daniel Drömann5Jan Rupp6Simon Graspeuntner7Klaus Dalhoff8Medical Clinic III, University Hospital Schleswig-Holstein/Campus Lübeck, Ratzeburger Allee 160, 23562 Lübeck, GermanyMedical Clinic III, University Hospital Schleswig-Holstein/Campus Lübeck, Ratzeburger Allee 160, 23562 Lübeck, GermanyMedical Clinic III, University Hospital Schleswig-Holstein/Campus Lübeck, Ratzeburger Allee 160, 23562 Lübeck, GermanyDepartment of Surgery, University Hospital Schleswig-Holstein/Campus Lübeck, Ratzeburger Allee 160, 23562 Lübeck, GermanyDepartment of Infectious Diseases and Microbiology, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, GermanyMedical Clinic III, University Hospital Schleswig-Holstein/Campus Lübeck, Ratzeburger Allee 160, 23562 Lübeck, GermanyDepartment of Infectious Diseases and Microbiology, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, GermanyDepartment of Infectious Diseases and Microbiology, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, GermanyMedical Clinic III, University Hospital Schleswig-Holstein/Campus Lübeck, Ratzeburger Allee 160, 23562 Lübeck, GermanyHuman airways are continuously colonized by microaspiration of microbiota. Less is known about the presence, origin and composition of microbiota in the lung parenchyma. In a study of 13 patients undergoing surgery for peripheral lung cancer microbiota composition was comparatively evaluated in upper airway, lower airway and lung tissue samples using 16S rDNA analysis. Bacterial density decreased stepwise from upper to lower airways and tissue. On a taxonomic level upper and lower airway microbiota were similar whereas lung tissue showed marked dissimilarities compared to lower airways that may reflect different environmental conditions shaping local microbiota and host immunity.https://www.mdpi.com/2076-2607/8/6/794respiratory microbiomelung tissue microbiomerespiratory infectioninnate immunity |
| spellingShingle | Lena Reinhold Andreas Möllering Sönke Wallis Emanuel Palade Kathrin Schäfer Daniel Drömann Jan Rupp Simon Graspeuntner Klaus Dalhoff Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer Microorganisms respiratory microbiome lung tissue microbiome respiratory infection innate immunity |
| title | Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer |
| title_full | Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer |
| title_fullStr | Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer |
| title_full_unstemmed | Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer |
| title_short | Dissimilarity of Airway and Lung Tissue Microbiota in Smokers Undergoing Surgery for Lung Cancer |
| title_sort | dissimilarity of airway and lung tissue microbiota in smokers undergoing surgery for lung cancer |
| topic | respiratory microbiome lung tissue microbiome respiratory infection innate immunity |
| url | https://www.mdpi.com/2076-2607/8/6/794 |
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