Human Xylosyltransferase I—An Important Linker between Acute Senescence and Fibrogenesis

Human Xylosyltransferase I—An Important Linker between Acute Senescence and Fibrogenesis

The human xylosyltransferase isoform XT-I catalyzes the initial step in proteoglycan biosynthesis and represents a biomarker of myofibroblast differentiation. Furthermore, XT-I overexpression is associated with fibrosis, whereby a fibrotic process initially develops from a dysregulated wound healing...

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Bibliographic Details
Main Authors: Vanessa Schmidt, Justus Ohmes, Thanh-Diep Ly, Bastian Fischer, Anika Kleine, Cornelius Knabbe, Isabel Faust-Hinse
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomedicines
Subjects:
Xylosyltransferase
acute senescence
cellular senescence
wound healing
fibrosis
myofibroblast
Online Access:https://www.mdpi.com/2227-9059/11/2/460

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