miR‐181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart

miR‐181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart

Background Translocation of miR‐181c into cardiac mitochondria downregulates the mitochondrial gene, mt‐COX1. miR‐181c/d−/− hearts experience less oxidative stress during ischemia/reperfusion (I/R) and are protected against I/R injury. Additionally, miR‐181c overexpression can increase mitochondrial...

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Bibliographic Details
Main Authors: Hemanth N. Banavath, Barbara Roman, Nathan Mackowski, Debjit Biswas, Junaid Afzal, Yohei Nomura, Soroosh Solhjoo, Brian O'Rourke, Mark Kohr, Elizabeth Murphy, Charles Steenbergen, Samarjit Das
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
microRNA
miRNA
mitochondria
mitomiR
mitochondrial calcium
heart failure
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.012919

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.119.012919

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