Clinical characteristics and management outcomes of acute retinal necrosis
Abstract This study investigates patient’s clinical characteristics and management outcomes of PCR-positive Acute Retinal Necrosis (ARN). The patient’s clinical characteristics of the disease, and therapeutic approaches were assessed. Data from the medical records of 40 eyes of 40 patients were anal...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-44310-4 |
| _version_ | 1797577008288366592 |
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| author | Elham Shiezadeh Seyedeh Maryam Hosseini Elham Bakhtiari Alireza Mojarrad Mehrdad Motamed Shariati |
| author_facet | Elham Shiezadeh Seyedeh Maryam Hosseini Elham Bakhtiari Alireza Mojarrad Mehrdad Motamed Shariati |
| author_sort | Elham Shiezadeh |
| collection | DOAJ |
| description | Abstract This study investigates patient’s clinical characteristics and management outcomes of PCR-positive Acute Retinal Necrosis (ARN). The patient’s clinical characteristics of the disease, and therapeutic approaches were assessed. Data from the medical records of 40 eyes of 40 patients were analyzed. The mean ± standard deviation (SD) of the age of the patients was 47.8 ± 14.1 years (16–84 years old). The median follow-up time was 160 days, with a range of 120–370 days. The mean ± SD of patients' primary and final BCVA was 1.24 ± 0.78 and 1.08 ± 0.86 LogMAR, respectively. The final BCVA increased significantly after the treatment in the last follow-up period in patients who did not undergo PPV (p = 0.029). Although, vision changes were not statistically significant in patients who underwent PPV (p = 0.549). 75% of our patients had a positive aqueous PCR for VZV, and the second most common causative agents were CMV and HSV (10% for each). Besides, rhegmatogenous retinal detachment (RRD) occurred in 25% of our patients. Our analysis showed that the presenting visual acuity and RRD occurrence are the significant prognostic factors for final blindness in ARN. |
| first_indexed | 2024-03-10T22:01:52Z |
| format | Article |
| id | doaj.art-e709dc35b24045739fed4479d013aecf |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T22:01:52Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e709dc35b24045739fed4479d013aecf2023-11-19T12:55:48ZengNature PortfolioScientific Reports2045-23222023-10-011311810.1038/s41598-023-44310-4Clinical characteristics and management outcomes of acute retinal necrosisElham Shiezadeh0Seyedeh Maryam Hosseini1Elham Bakhtiari2Alireza Mojarrad3Mehrdad Motamed Shariati4Eye Research Center, Khatam Al-Anbia Eye Hospital, Mashhad University of Medical SciencesEye Research Center, Khatam Al-Anbia Eye Hospital, Mashhad University of Medical SciencesEye Research Center, Khatam Al-Anbia Eye Hospital, Mashhad University of Medical SciencesEye Research Center, Khatam Al-Anbia Eye Hospital, Mashhad University of Medical SciencesEye Research Center, Khatam Al-Anbia Eye Hospital, Mashhad University of Medical SciencesAbstract This study investigates patient’s clinical characteristics and management outcomes of PCR-positive Acute Retinal Necrosis (ARN). The patient’s clinical characteristics of the disease, and therapeutic approaches were assessed. Data from the medical records of 40 eyes of 40 patients were analyzed. The mean ± standard deviation (SD) of the age of the patients was 47.8 ± 14.1 years (16–84 years old). The median follow-up time was 160 days, with a range of 120–370 days. The mean ± SD of patients' primary and final BCVA was 1.24 ± 0.78 and 1.08 ± 0.86 LogMAR, respectively. The final BCVA increased significantly after the treatment in the last follow-up period in patients who did not undergo PPV (p = 0.029). Although, vision changes were not statistically significant in patients who underwent PPV (p = 0.549). 75% of our patients had a positive aqueous PCR for VZV, and the second most common causative agents were CMV and HSV (10% for each). Besides, rhegmatogenous retinal detachment (RRD) occurred in 25% of our patients. Our analysis showed that the presenting visual acuity and RRD occurrence are the significant prognostic factors for final blindness in ARN.https://doi.org/10.1038/s41598-023-44310-4 |
| spellingShingle | Elham Shiezadeh Seyedeh Maryam Hosseini Elham Bakhtiari Alireza Mojarrad Mehrdad Motamed Shariati Clinical characteristics and management outcomes of acute retinal necrosis Scientific Reports |
| title | Clinical characteristics and management outcomes of acute retinal necrosis |
| title_full | Clinical characteristics and management outcomes of acute retinal necrosis |
| title_fullStr | Clinical characteristics and management outcomes of acute retinal necrosis |
| title_full_unstemmed | Clinical characteristics and management outcomes of acute retinal necrosis |
| title_short | Clinical characteristics and management outcomes of acute retinal necrosis |
| title_sort | clinical characteristics and management outcomes of acute retinal necrosis |
| url | https://doi.org/10.1038/s41598-023-44310-4 |
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