Case report of a renal cell carcinoma patient with acute pancreatitis under both sunitinib and axitinib treatment
Sunitinib and axitinib are oral tyrosine kinase inhibitors (TKI) that is commonly used in the treatment of metastatic renal cell carcinoma (RCC) as it has been shown to improve the progression-free survival of patients compared with sorafenib. Hypertension, palmar-plantar erythrodysesthesia, diarrhe...
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| Format: | Article |
| Language: | English |
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Turkiye Klinikleri
2016-08-01
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| Series: | Journal of Oncological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452336416300267 |
| _version_ | 1797906212599103488 |
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| author | Utku Oflazoglu Umut Varol Ahmet Alacacioglu Tarik Salman Necla Demir Huseyin Salih Semiz Aziz Karaoglu Ilhan Oztop |
| author_facet | Utku Oflazoglu Umut Varol Ahmet Alacacioglu Tarik Salman Necla Demir Huseyin Salih Semiz Aziz Karaoglu Ilhan Oztop |
| author_sort | Utku Oflazoglu |
| collection | DOAJ |
| description | Sunitinib and axitinib are oral tyrosine kinase inhibitors (TKI) that is commonly used in the treatment of metastatic renal cell carcinoma (RCC) as it has been shown to improve the progression-free survival of patients compared with sorafenib. Hypertension, palmar-plantar erythrodysesthesia, diarrhea, decreased appetite, nausea, and fatigue are common adverse events associated with them. We declared the first case report of a RCC patient with acute pancreatitis both under sunitinib and axitinib treatment. A 63-year-old male RCC patient who had been previously treated with interferon alfa 2b, sunitinib, everolimus and axitinib was hospitalized for acute pancreatitis four months after the onset of sunitinib therapy and five months after the onset of axitinib treatment. Symptoms and levels of serum lipase were normalized within one week after drug was withheld. Acute pancreatitis is a rare side effect of TKI and because of this, in patients under TKI treatment abdominal pain should be considered as a possible symptom of acute pancreatitis. |
| first_indexed | 2024-04-10T10:18:20Z |
| format | Article |
| id | doaj.art-e70a2971870d440a8d674c4258bbba53 |
| institution | Directory Open Access Journal |
| issn | 2452-3364 |
| language | English |
| last_indexed | 2024-04-10T10:18:20Z |
| publishDate | 2016-08-01 |
| publisher | Turkiye Klinikleri |
| record_format | Article |
| series | Journal of Oncological Sciences |
| spelling | doaj.art-e70a2971870d440a8d674c4258bbba532023-02-15T16:21:48ZengTurkiye KlinikleriJournal of Oncological Sciences2452-33642016-08-0122636510.1016/j.jons.2016.07.002Case report of a renal cell carcinoma patient with acute pancreatitis under both sunitinib and axitinib treatmentUtku Oflazoglu0Umut Varol1Ahmet Alacacioglu2Tarik Salman3Necla Demir4Huseyin Salih Semiz5Aziz Karaoglu6Ilhan Oztop7Department of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Resarch Hospital, Izmir, TurkeyDepartment of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Resarch Hospital, Izmir, TurkeyDepartment of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Resarch Hospital, Izmir, TurkeyDepartment of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Resarch Hospital, Izmir, TurkeyDepartment of Medical Oncology, Dokuz Eylul University, Izmir, TurkeyDepartment of Medical Oncology, Dokuz Eylul University, Izmir, TurkeyDepartment of Medical Oncology, Dokuz Eylul University, Izmir, TurkeyDepartment of Medical Oncology, Dokuz Eylul University, Izmir, TurkeySunitinib and axitinib are oral tyrosine kinase inhibitors (TKI) that is commonly used in the treatment of metastatic renal cell carcinoma (RCC) as it has been shown to improve the progression-free survival of patients compared with sorafenib. Hypertension, palmar-plantar erythrodysesthesia, diarrhea, decreased appetite, nausea, and fatigue are common adverse events associated with them. We declared the first case report of a RCC patient with acute pancreatitis both under sunitinib and axitinib treatment. A 63-year-old male RCC patient who had been previously treated with interferon alfa 2b, sunitinib, everolimus and axitinib was hospitalized for acute pancreatitis four months after the onset of sunitinib therapy and five months after the onset of axitinib treatment. Symptoms and levels of serum lipase were normalized within one week after drug was withheld. Acute pancreatitis is a rare side effect of TKI and because of this, in patients under TKI treatment abdominal pain should be considered as a possible symptom of acute pancreatitis.http://www.sciencedirect.com/science/article/pii/S2452336416300267SunitinibAxitinibRenal cell carcinomaPancreatitisSide effects |
| spellingShingle | Utku Oflazoglu Umut Varol Ahmet Alacacioglu Tarik Salman Necla Demir Huseyin Salih Semiz Aziz Karaoglu Ilhan Oztop Case report of a renal cell carcinoma patient with acute pancreatitis under both sunitinib and axitinib treatment Journal of Oncological Sciences Sunitinib Axitinib Renal cell carcinoma Pancreatitis Side effects |
| title | Case report of a renal cell carcinoma patient with acute pancreatitis under both sunitinib and axitinib treatment |
| title_full | Case report of a renal cell carcinoma patient with acute pancreatitis under both sunitinib and axitinib treatment |
| title_fullStr | Case report of a renal cell carcinoma patient with acute pancreatitis under both sunitinib and axitinib treatment |
| title_full_unstemmed | Case report of a renal cell carcinoma patient with acute pancreatitis under both sunitinib and axitinib treatment |
| title_short | Case report of a renal cell carcinoma patient with acute pancreatitis under both sunitinib and axitinib treatment |
| title_sort | case report of a renal cell carcinoma patient with acute pancreatitis under both sunitinib and axitinib treatment |
| topic | Sunitinib Axitinib Renal cell carcinoma Pancreatitis Side effects |
| url | http://www.sciencedirect.com/science/article/pii/S2452336416300267 |
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