CXCL13 expressed on inflamed cerebral blood vessels recruit IL-21 producing TFH cells to damage neurons following stroke

CXCL13 expressed on inflamed cerebral blood vessels recruit IL-21 producing TFH cells to damage neurons following stroke

Abstract Background Ischemic stroke is a leading cause of mortality worldwide, largely due to the inflammatory response to brain ischemia during post-stroke reperfusion. Despite ongoing intensive research, there have not been any clinically approved drugs targeting the inflammatory component to stro...

Full description

Bibliographic Details
Main Authors: Aditya Rayasam, Julie A. Kijak, Lee Kissel, Yun Hwa Choi, Taehee Kim, Martin Hsu, Dinesh Joshi, Collin J. Laaker, Peter Cismaru, Anders Lindstedt, Krisztian Kovacs, Raghu Vemuganti, Shing Yan Chiu, Thanthrige Thiunuwan Priyathilaka, Matyas Sandor, Zsuzsanna Fabry
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Neuroinflammation
Subjects:
Lymphocytes
Neuroinflammation
Stroke
Immune
Brain
IL-21
Online Access:https://doi.org/10.1186/s12974-022-02490-2

Internet

https://doi.org/10.1186/s12974-022-02490-2

Similar Items