Association between glycosylated hemoglobin A1c and bone biochemical markers in type 2 diabetic postmenopausal women: a cross-sectional study
Abstract Background type 2 diabetes mellitus (T2DM) is a complicated disease that can affect bone health, but the change in bone biochemical markers caused by T2DM was controversial, so the aim of this study was to investigate whether there was a discrepancy in the levels of bone biochemical markers...
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12902-019-0357-4 |
| _version_ | 1828794777960710144 |
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| author | Lianzi Wang Tao Li Jiaqing Liu Xian Wu Huihui Wang Xuemei Li Enjun Xu Qiuli Chen Chuan Yan Huimin Li Yuanhong Xu Wei Wei |
| author_facet | Lianzi Wang Tao Li Jiaqing Liu Xian Wu Huihui Wang Xuemei Li Enjun Xu Qiuli Chen Chuan Yan Huimin Li Yuanhong Xu Wei Wei |
| author_sort | Lianzi Wang |
| collection | DOAJ |
| description | Abstract Background type 2 diabetes mellitus (T2DM) is a complicated disease that can affect bone health, but the change in bone biochemical markers caused by T2DM was controversial, so the aim of this study was to investigate whether there was a discrepancy in the levels of bone biochemical markers between postmenopausal women with T2DM and non-diabetic women and to explore the relationship between the level of glycosylated hemoglobin A1c (HbA1c) and bone biochemical markers in these subjects. Methods A total of 237 type 2 diabetic postmenopausal women visiting the First Affiliated Hospital of Anhui Medical University from January 2017 to October 2018 and 93 healthy postmenopausal women were retrospectively enrolled. The differences in the levels of bone biochemical markers between patients and controls were analyzed by one-way ANOVA or chi-square test. The relationship between HbA1c and bone biochemical markers was analyzed by multivariate regression, forest plot and fitted curve. Results Bone formation markers including N-MID osteocalcin and procollagen type 1 amino-terminal pro-peptide (PINP) were decreased in postmenopausal women with T2DM compared to controls (17.42 ± 9.50 vs 23.67 ± 7.58, p < 0.001; 48.47 ± 27.27 vs 65.86 ± 21.06, p < 0.001, respectively), but the bone resorption markers β-crossLaps (β-CTX) was no difference between the two groups (0.57 ± 0.28 vs 0.55 ± 0.21, p = 0.868). Multivariate regression showed that HbA1c was inversely associated with N-MID osteocalcin and PINP after adjusting for age, BMI, menopause’s years, diabetic duration, TC, TG, HDL-c, LDL-c, creatinine, UA and eGFR. The adjusted coefficients for N-MID osteocalcin and PINP per 1% HbA1c decrease were − 0.71 (− 1.19, − 0.22) and − 1.79 (− 3.30, − 0.28), respectively. A segmentation effect was seen in the fitted curve between HbA1c and β-CTX with an inflection point at 7.4% of HbA1c, the highest quartile of β-CTX (> = 0.74 ng/ml) showed a significantly negative with HbA1c. No significant association was seen between HbA1c and other biochemical markers. Conclusions Our study found that bone formation was inhibited in postmenopausal women with T2DM, but bone resorption was not affected, and poor glycemic control was related to lower levels of bone formation, may increase the risk of bone fracture in postmenopausal women with T2DM. |
| first_indexed | 2024-12-12T03:52:10Z |
| format | Article |
| id | doaj.art-e7114556525f4527a1d9af1aed6b2291 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-12T03:52:10Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-e7114556525f4527a1d9af1aed6b22912022-12-22T00:39:22ZengBMCBMC Endocrine Disorders1472-68232019-03-011911910.1186/s12902-019-0357-4Association between glycosylated hemoglobin A1c and bone biochemical markers in type 2 diabetic postmenopausal women: a cross-sectional studyLianzi Wang0Tao Li1Jiaqing Liu2Xian Wu3Huihui Wang4Xuemei Li5Enjun Xu6Qiuli Chen7Chuan Yan8Huimin Li9Yuanhong Xu10Wei Wei11Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical UniversityInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Anhui Anti-inflammatory and Immune Medicine innovation teamAbstract Background type 2 diabetes mellitus (T2DM) is a complicated disease that can affect bone health, but the change in bone biochemical markers caused by T2DM was controversial, so the aim of this study was to investigate whether there was a discrepancy in the levels of bone biochemical markers between postmenopausal women with T2DM and non-diabetic women and to explore the relationship between the level of glycosylated hemoglobin A1c (HbA1c) and bone biochemical markers in these subjects. Methods A total of 237 type 2 diabetic postmenopausal women visiting the First Affiliated Hospital of Anhui Medical University from January 2017 to October 2018 and 93 healthy postmenopausal women were retrospectively enrolled. The differences in the levels of bone biochemical markers between patients and controls were analyzed by one-way ANOVA or chi-square test. The relationship between HbA1c and bone biochemical markers was analyzed by multivariate regression, forest plot and fitted curve. Results Bone formation markers including N-MID osteocalcin and procollagen type 1 amino-terminal pro-peptide (PINP) were decreased in postmenopausal women with T2DM compared to controls (17.42 ± 9.50 vs 23.67 ± 7.58, p < 0.001; 48.47 ± 27.27 vs 65.86 ± 21.06, p < 0.001, respectively), but the bone resorption markers β-crossLaps (β-CTX) was no difference between the two groups (0.57 ± 0.28 vs 0.55 ± 0.21, p = 0.868). Multivariate regression showed that HbA1c was inversely associated with N-MID osteocalcin and PINP after adjusting for age, BMI, menopause’s years, diabetic duration, TC, TG, HDL-c, LDL-c, creatinine, UA and eGFR. The adjusted coefficients for N-MID osteocalcin and PINP per 1% HbA1c decrease were − 0.71 (− 1.19, − 0.22) and − 1.79 (− 3.30, − 0.28), respectively. A segmentation effect was seen in the fitted curve between HbA1c and β-CTX with an inflection point at 7.4% of HbA1c, the highest quartile of β-CTX (> = 0.74 ng/ml) showed a significantly negative with HbA1c. No significant association was seen between HbA1c and other biochemical markers. Conclusions Our study found that bone formation was inhibited in postmenopausal women with T2DM, but bone resorption was not affected, and poor glycemic control was related to lower levels of bone formation, may increase the risk of bone fracture in postmenopausal women with T2DM.http://link.springer.com/article/10.1186/s12902-019-0357-4HbA1cN-MID osteocalcinPINPPTHβ-CTX25(oh)D3 |
| spellingShingle | Lianzi Wang Tao Li Jiaqing Liu Xian Wu Huihui Wang Xuemei Li Enjun Xu Qiuli Chen Chuan Yan Huimin Li Yuanhong Xu Wei Wei Association between glycosylated hemoglobin A1c and bone biochemical markers in type 2 diabetic postmenopausal women: a cross-sectional study BMC Endocrine Disorders HbA1c N-MID osteocalcin PINP PTH β-CTX 25(oh)D3 |
| title | Association between glycosylated hemoglobin A1c and bone biochemical markers in type 2 diabetic postmenopausal women: a cross-sectional study |
| title_full | Association between glycosylated hemoglobin A1c and bone biochemical markers in type 2 diabetic postmenopausal women: a cross-sectional study |
| title_fullStr | Association between glycosylated hemoglobin A1c and bone biochemical markers in type 2 diabetic postmenopausal women: a cross-sectional study |
| title_full_unstemmed | Association between glycosylated hemoglobin A1c and bone biochemical markers in type 2 diabetic postmenopausal women: a cross-sectional study |
| title_short | Association between glycosylated hemoglobin A1c and bone biochemical markers in type 2 diabetic postmenopausal women: a cross-sectional study |
| title_sort | association between glycosylated hemoglobin a1c and bone biochemical markers in type 2 diabetic postmenopausal women a cross sectional study |
| topic | HbA1c N-MID osteocalcin PINP PTH β-CTX 25(oh)D3 |
| url | http://link.springer.com/article/10.1186/s12902-019-0357-4 |
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