Functional brain activity in patients with amnestic mild cognitive impairment: an rs-fMRI study
BackgroundAmnestic mild cognitive impairment (aMCI) is an early stage of Alzheimer’s disease (AD). Regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) are employed to explore spontaneous brain function in patients with aMCI. This study applied ALFF and ReHo indicators to an...
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1244696/full |
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| author | Jinhuan Yue Jinhuan Yue Sheng-wang Han Xiao Liu Song Wang Wei-wei Zhao Li-na Cai Dan-na Cao Jeffrey Zhongxue Mah Yu Hou Xuan Cui Yang Wang Li Chen Ang Li Xiao-ling Li Guanhu Yang Qinhong Zhang Qinhong Zhang |
| author_facet | Jinhuan Yue Jinhuan Yue Sheng-wang Han Xiao Liu Song Wang Wei-wei Zhao Li-na Cai Dan-na Cao Jeffrey Zhongxue Mah Yu Hou Xuan Cui Yang Wang Li Chen Ang Li Xiao-ling Li Guanhu Yang Qinhong Zhang Qinhong Zhang |
| author_sort | Jinhuan Yue |
| collection | DOAJ |
| description | BackgroundAmnestic mild cognitive impairment (aMCI) is an early stage of Alzheimer’s disease (AD). Regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) are employed to explore spontaneous brain function in patients with aMCI. This study applied ALFF and ReHo indicators to analyze the neural mechanism of aMCI by resting-state functional magnetic resonance imaging (rs-fMRI).MethodsTwenty-six patients with aMCI were included and assigned to the aMCI group. The other 26 healthy subjects were included as a healthy control (HC) group. Rs-fMRI was performed for all participants in both groups. Between-group comparisons of demographic data and neuropsychological scores were analyzed using SPSS 25.0. Functional imaging data were analyzed using DPARSF and SPM12 software based on MATLAB 2017a. Gender, age, and years of education were used as covariates to obtain ALFF and ReHo indices.ResultsCompared with HC group, ALFF decreased in the left fusiform gyrus, left superior temporal gyrus, and increased in the left cerebellum 8, left inferior temporal gyrus, left superior frontal gyrus (BA11), and right inferior temporal gyrus (BA20) in the aMCI group (p < 0.05, FWE correction). In addition, ReHo decreased in the right middle temporal gyrus and right anterior cuneiform lobe, while it increased in the left middle temporal gyrus, left inferior temporal gyrus, cerebellar vermis, right parahippocampal gyrus, left caudate nucleus, right thalamus, and left superior frontal gyrus (BA6) (p < 0.05, FWE correction). In the aMCI group, the ALFF of the left superior frontal gyrus was negatively correlated with Montreal Cognitive Assessment (MoCA) score (r = −0.437, p = 0.026), and the ALFF of the left superior temporal gyrus was positively correlated with the MoCA score (r = 0.550, p = 0.004). The ReHo of the right hippocampus was negatively correlated with the Mini-Mental State Examination (MMSE) score (r = −0.434, p = 0.027), and the ReHo of the right middle temporal gyrus was positively correlated with MMSE score (r = 0.392, p = 0.048).ConclusionFunctional changes in multiple brain regions rather than in a single brain region have been observed in patients with aMCI. The abnormal activity of multiple specific brain regions may be a manifestation of impaired central function in patients with aMCI. |
| first_indexed | 2024-03-12T14:01:17Z |
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| id | doaj.art-e714a42c220a4c8388a34ab73dffef29 |
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| last_indexed | 2024-03-12T14:01:17Z |
| publishDate | 2023-08-01 |
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| spelling | doaj.art-e714a42c220a4c8388a34ab73dffef292023-08-22T07:11:38ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-08-011410.3389/fneur.2023.12446961244696Functional brain activity in patients with amnestic mild cognitive impairment: an rs-fMRI studyJinhuan Yue0Jinhuan Yue1Sheng-wang Han2Xiao Liu3Song Wang4Wei-wei Zhao5Li-na Cai6Dan-na Cao7Jeffrey Zhongxue Mah8Yu Hou9Xuan Cui10Yang Wang11Li Chen12Ang Li13Xiao-ling Li14Guanhu Yang15Qinhong Zhang16Qinhong Zhang17Shenzhen Frontiers in Chinese Medicine Research Co., Ltd., Shenzhen, ChinaDepartment of Acupuncture and Moxibustion, Vitality University, Hayward, CA, United StatesDepartment of Third Rehabilitation Medicine, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Pediatrics, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Radiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaMSD R&D (China) Co., Ltd., Beijing, ChinaGraduate School of Heilongjiang University of Chinese Medicine, Harbin, ChinaDivision of CT and MRI, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Acupuncture and Moxibustion, Vitality University, Hayward, CA, United StatesDepartment of Gynecology, Harbin Traditional Chinese Medicine Hospital, Harbin, ChinaGraduate School of Heilongjiang University of Chinese Medicine, Harbin, ChinaDivision of CT and MRI, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China0Confucius Institute for TCM, London South Bank University, London, United Kingdom1Sanofi-Aventis China Investment Co., Ltd., Beijing, ChinaDivision of CT and MRI, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China2Department of Specialty Medicine, Ohio University, Athens, OH, United StatesShenzhen Frontiers in Chinese Medicine Research Co., Ltd., Shenzhen, China3Department of Acupuncture and Moxibustion, Heilongjiang University of Chinese Medicine, Harbin, ChinaBackgroundAmnestic mild cognitive impairment (aMCI) is an early stage of Alzheimer’s disease (AD). Regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) are employed to explore spontaneous brain function in patients with aMCI. This study applied ALFF and ReHo indicators to analyze the neural mechanism of aMCI by resting-state functional magnetic resonance imaging (rs-fMRI).MethodsTwenty-six patients with aMCI were included and assigned to the aMCI group. The other 26 healthy subjects were included as a healthy control (HC) group. Rs-fMRI was performed for all participants in both groups. Between-group comparisons of demographic data and neuropsychological scores were analyzed using SPSS 25.0. Functional imaging data were analyzed using DPARSF and SPM12 software based on MATLAB 2017a. Gender, age, and years of education were used as covariates to obtain ALFF and ReHo indices.ResultsCompared with HC group, ALFF decreased in the left fusiform gyrus, left superior temporal gyrus, and increased in the left cerebellum 8, left inferior temporal gyrus, left superior frontal gyrus (BA11), and right inferior temporal gyrus (BA20) in the aMCI group (p < 0.05, FWE correction). In addition, ReHo decreased in the right middle temporal gyrus and right anterior cuneiform lobe, while it increased in the left middle temporal gyrus, left inferior temporal gyrus, cerebellar vermis, right parahippocampal gyrus, left caudate nucleus, right thalamus, and left superior frontal gyrus (BA6) (p < 0.05, FWE correction). In the aMCI group, the ALFF of the left superior frontal gyrus was negatively correlated with Montreal Cognitive Assessment (MoCA) score (r = −0.437, p = 0.026), and the ALFF of the left superior temporal gyrus was positively correlated with the MoCA score (r = 0.550, p = 0.004). The ReHo of the right hippocampus was negatively correlated with the Mini-Mental State Examination (MMSE) score (r = −0.434, p = 0.027), and the ReHo of the right middle temporal gyrus was positively correlated with MMSE score (r = 0.392, p = 0.048).ConclusionFunctional changes in multiple brain regions rather than in a single brain region have been observed in patients with aMCI. The abnormal activity of multiple specific brain regions may be a manifestation of impaired central function in patients with aMCI.https://www.frontiersin.org/articles/10.3389/fneur.2023.1244696/fullamnestic mild cognitive impairmentresting-state functional magnetic resonance imagingregional homogeneityamplitude of low-frequency fluctuationimaging marker |
| spellingShingle | Jinhuan Yue Jinhuan Yue Sheng-wang Han Xiao Liu Song Wang Wei-wei Zhao Li-na Cai Dan-na Cao Jeffrey Zhongxue Mah Yu Hou Xuan Cui Yang Wang Li Chen Ang Li Xiao-ling Li Guanhu Yang Qinhong Zhang Qinhong Zhang Functional brain activity in patients with amnestic mild cognitive impairment: an rs-fMRI study Frontiers in Neurology amnestic mild cognitive impairment resting-state functional magnetic resonance imaging regional homogeneity amplitude of low-frequency fluctuation imaging marker |
| title | Functional brain activity in patients with amnestic mild cognitive impairment: an rs-fMRI study |
| title_full | Functional brain activity in patients with amnestic mild cognitive impairment: an rs-fMRI study |
| title_fullStr | Functional brain activity in patients with amnestic mild cognitive impairment: an rs-fMRI study |
| title_full_unstemmed | Functional brain activity in patients with amnestic mild cognitive impairment: an rs-fMRI study |
| title_short | Functional brain activity in patients with amnestic mild cognitive impairment: an rs-fMRI study |
| title_sort | functional brain activity in patients with amnestic mild cognitive impairment an rs fmri study |
| topic | amnestic mild cognitive impairment resting-state functional magnetic resonance imaging regional homogeneity amplitude of low-frequency fluctuation imaging marker |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1244696/full |
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