Ventilatory drive and the apnea-hypopnea index in six-to-twelve year old children
<p>Abstract</p> <p>Background</p> <p>We tested the hypothesis that ventilatory drive in hypoxia and hypercapnia is inversely correlated with the number of hypopneas and obstructive apneas per hour of sleep (obstructive apnea hypopnea index, OAHI) in children.</p>...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2004-04-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2466/4/4 |
| _version_ | 1818488573734682624 |
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| author | Fregosi Ralph F Quan Stuart F Jackson Andrew C Kaemingk Kris L Morgan Wayne J Goodwin Jamie L Reeder Jenny C Cabrera Rosaria K Antonio Elena |
| author_facet | Fregosi Ralph F Quan Stuart F Jackson Andrew C Kaemingk Kris L Morgan Wayne J Goodwin Jamie L Reeder Jenny C Cabrera Rosaria K Antonio Elena |
| author_sort | Fregosi Ralph F |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>We tested the hypothesis that ventilatory drive in hypoxia and hypercapnia is inversely correlated with the number of hypopneas and obstructive apneas per hour of sleep (obstructive apnea hypopnea index, OAHI) in children.</p> <p>Methods</p> <p>Fifty children, 6 to 12 years of age were studied. Participants had an in-home unattended polysomnogram to compute the OAHI. We subsequently estimated ventilatory drive in normoxia, at two levels of isocapnic hypoxia, and at three levels of hyperoxic hypercapnia in each subject. Experiments were done during wakefulness, and the mouth occlusion pressure measured 0.1 seconds after inspiratory onset (P<sub>0.1</sub>) was measured in all conditions. The slope of the relation between P<sub>0.1 </sub>and the partial pressure of end-tidal O<sub>2 </sub>or CO<sub>2 </sub>(P<sub>ET</sub>O<sub>2 </sub>and P<sub>ET</sub>CO<sub>2</sub>) served as the index of hypoxic or hypercapnic ventilatory drive.</p> <p>Results</p> <p>Hypoxic ventilatory drive correlated inversely with OAHI (r = -0.31, P = 0.041), but the hypercapnic ventilatory drive did not (r = -0.19, P = 0.27). We also found that the resting P<sub>ET</sub>CO<sub>2 </sub>was significantly and positively correlated with the OAHI, suggesting that high OAHI values were associated with resting CO<sub>2 </sub>retention.</p> <p>Conclusions</p> <p>In awake children the OAHI correlates inversely with the hypoxic ventilatory drive and positively with the resting P<sub>ET</sub>CO<sub>2</sub>. Whether or not diminished hypoxic drive or resting CO<sub>2 </sub>retention while awake can explain the severity of sleep-disordered breathing in this population is uncertain, but a reduced hypoxic ventilatory drive and resting CO<sub>2 </sub>retention are associated with sleep-disordered breathing in 6–12 year old children.</p> |
| first_indexed | 2024-12-10T16:52:57Z |
| format | Article |
| id | doaj.art-e71690c733c74239a9a770c81ef94f84 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-10T16:52:57Z |
| publishDate | 2004-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-e71690c733c74239a9a770c81ef94f842022-12-22T01:40:51ZengBMCBMC Pulmonary Medicine1471-24662004-04-0141410.1186/1471-2466-4-4Ventilatory drive and the apnea-hypopnea index in six-to-twelve year old childrenFregosi Ralph FQuan Stuart FJackson Andrew CKaemingk Kris LMorgan Wayne JGoodwin Jamie LReeder Jenny CCabrera Rosaria KAntonio Elena<p>Abstract</p> <p>Background</p> <p>We tested the hypothesis that ventilatory drive in hypoxia and hypercapnia is inversely correlated with the number of hypopneas and obstructive apneas per hour of sleep (obstructive apnea hypopnea index, OAHI) in children.</p> <p>Methods</p> <p>Fifty children, 6 to 12 years of age were studied. Participants had an in-home unattended polysomnogram to compute the OAHI. We subsequently estimated ventilatory drive in normoxia, at two levels of isocapnic hypoxia, and at three levels of hyperoxic hypercapnia in each subject. Experiments were done during wakefulness, and the mouth occlusion pressure measured 0.1 seconds after inspiratory onset (P<sub>0.1</sub>) was measured in all conditions. The slope of the relation between P<sub>0.1 </sub>and the partial pressure of end-tidal O<sub>2 </sub>or CO<sub>2 </sub>(P<sub>ET</sub>O<sub>2 </sub>and P<sub>ET</sub>CO<sub>2</sub>) served as the index of hypoxic or hypercapnic ventilatory drive.</p> <p>Results</p> <p>Hypoxic ventilatory drive correlated inversely with OAHI (r = -0.31, P = 0.041), but the hypercapnic ventilatory drive did not (r = -0.19, P = 0.27). We also found that the resting P<sub>ET</sub>CO<sub>2 </sub>was significantly and positively correlated with the OAHI, suggesting that high OAHI values were associated with resting CO<sub>2 </sub>retention.</p> <p>Conclusions</p> <p>In awake children the OAHI correlates inversely with the hypoxic ventilatory drive and positively with the resting P<sub>ET</sub>CO<sub>2</sub>. Whether or not diminished hypoxic drive or resting CO<sub>2 </sub>retention while awake can explain the severity of sleep-disordered breathing in this population is uncertain, but a reduced hypoxic ventilatory drive and resting CO<sub>2 </sub>retention are associated with sleep-disordered breathing in 6–12 year old children.</p>http://www.biomedcentral.com/1471-2466/4/4control of breathinghypoxia, hypercapnia, mouth occlusion pressureapnea-hypopnea index |
| spellingShingle | Fregosi Ralph F Quan Stuart F Jackson Andrew C Kaemingk Kris L Morgan Wayne J Goodwin Jamie L Reeder Jenny C Cabrera Rosaria K Antonio Elena Ventilatory drive and the apnea-hypopnea index in six-to-twelve year old children BMC Pulmonary Medicine control of breathing hypoxia, hypercapnia, mouth occlusion pressure apnea-hypopnea index |
| title | Ventilatory drive and the apnea-hypopnea index in six-to-twelve year old children |
| title_full | Ventilatory drive and the apnea-hypopnea index in six-to-twelve year old children |
| title_fullStr | Ventilatory drive and the apnea-hypopnea index in six-to-twelve year old children |
| title_full_unstemmed | Ventilatory drive and the apnea-hypopnea index in six-to-twelve year old children |
| title_short | Ventilatory drive and the apnea-hypopnea index in six-to-twelve year old children |
| title_sort | ventilatory drive and the apnea hypopnea index in six to twelve year old children |
| topic | control of breathing hypoxia, hypercapnia, mouth occlusion pressure apnea-hypopnea index |
| url | http://www.biomedcentral.com/1471-2466/4/4 |
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