Association of young age and male sex with primary sclerosing cholangitis in Taiwanese patients with inflammatory bowel disease
Background/Aims Primary sclerosing cholangitis (PSC) is associated with inflammatory bowel disease (IBD). We aimed to evaluate the prevalence, clinical manifestation, and outcomes of PSC in Taiwanese patients with IBD. Methods This retrospective study enrolled patients with IBD admitted from January...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of Intestinal Diseases
2022-04-01
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| Series: | Intestinal Research |
| Subjects: | |
| Online Access: | http://www.irjournal.org/upload/pdf/ir-2021-00042.pdf |
| _version_ | 1817989961364799488 |
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| author | Meng-Tzu Weng I-Lun Shih Chien-Chih Tung Yew-Loong Leong Ming-Jium Shieh Cheng-Yi Wang Jau-Min Wong Yen-Hsuan Ni Shu-Chen Wei |
| author_facet | Meng-Tzu Weng I-Lun Shih Chien-Chih Tung Yew-Loong Leong Ming-Jium Shieh Cheng-Yi Wang Jau-Min Wong Yen-Hsuan Ni Shu-Chen Wei |
| author_sort | Meng-Tzu Weng |
| collection | DOAJ |
| description | Background/Aims Primary sclerosing cholangitis (PSC) is associated with inflammatory bowel disease (IBD). We aimed to evaluate the prevalence, clinical manifestation, and outcomes of PSC in Taiwanese patients with IBD. Methods This retrospective study enrolled patients with IBD admitted from January 1, 1996, to December 31, 2018, to National Taiwan University Hospital. A case-matched analysis was performed comparing patients with IBD with and without PSC according to age, sex, and time of admission, with ratios of 1:4 and 1:2 in the adult and pediatric groups, respectively. Results In total, 763 patients with IBD were enrolled, 12 of whom were also diagnosed with PSC (1.57%). All these patients had ulcerative colitis (UC). A greater incidence of IBD with PSC was observed in younger patients than in older patients. Male sex was a risk factor for PSC in pediatric patients with IBD (P=0.015); 75% of these patients were diagnosed with PSC along with or after the diagnosis of UC. There was no significant difference in colitis extent and severity between the groups; however, a higher proportion of rectal sparing was observed in patients with PSC (P=0.001). There was no significant difference in cancer development between the groups (P=0.679). Conclusions A 1.57% prevalence of PSC was observed in Taiwanese patients with IBD. The majority of patients with IBD and PSC were men and were diagnosed at a younger age. Hence, routine evaluation of biliary enzymes and liver imaging is recommended in young male patients with IBD. |
| first_indexed | 2024-04-14T00:53:03Z |
| format | Article |
| id | doaj.art-e716a760a9e04e3b81642d1a6d4e0913 |
| institution | Directory Open Access Journal |
| issn | 1598-9100 2288-1956 |
| language | English |
| last_indexed | 2024-04-14T00:53:03Z |
| publishDate | 2022-04-01 |
| publisher | Korean Association for the Study of Intestinal Diseases |
| record_format | Article |
| series | Intestinal Research |
| spelling | doaj.art-e716a760a9e04e3b81642d1a6d4e09132022-12-22T02:21:42ZengKorean Association for the Study of Intestinal DiseasesIntestinal Research1598-91002288-19562022-04-0120222423010.5217/ir.2021.00042936Association of young age and male sex with primary sclerosing cholangitis in Taiwanese patients with inflammatory bowel diseaseMeng-Tzu Weng0I-Lun Shih1Chien-Chih Tung2Yew-Loong Leong3Ming-Jium Shieh4Cheng-Yi Wang5Jau-Min Wong6Yen-Hsuan Ni7Shu-Chen Wei8 Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei City, Taiwan Department of Medical Imaging, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei City, Taiwan Department of Integrated Diagnostics and Therapeutics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei City, Taiwan Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei City, Taiwan Department of Oncology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei City, Taiwan Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei City, Taiwan Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei City, Taiwan Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei City, Taiwan Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei City, TaiwanBackground/Aims Primary sclerosing cholangitis (PSC) is associated with inflammatory bowel disease (IBD). We aimed to evaluate the prevalence, clinical manifestation, and outcomes of PSC in Taiwanese patients with IBD. Methods This retrospective study enrolled patients with IBD admitted from January 1, 1996, to December 31, 2018, to National Taiwan University Hospital. A case-matched analysis was performed comparing patients with IBD with and without PSC according to age, sex, and time of admission, with ratios of 1:4 and 1:2 in the adult and pediatric groups, respectively. Results In total, 763 patients with IBD were enrolled, 12 of whom were also diagnosed with PSC (1.57%). All these patients had ulcerative colitis (UC). A greater incidence of IBD with PSC was observed in younger patients than in older patients. Male sex was a risk factor for PSC in pediatric patients with IBD (P=0.015); 75% of these patients were diagnosed with PSC along with or after the diagnosis of UC. There was no significant difference in colitis extent and severity between the groups; however, a higher proportion of rectal sparing was observed in patients with PSC (P=0.001). There was no significant difference in cancer development between the groups (P=0.679). Conclusions A 1.57% prevalence of PSC was observed in Taiwanese patients with IBD. The majority of patients with IBD and PSC were men and were diagnosed at a younger age. Hence, routine evaluation of biliary enzymes and liver imaging is recommended in young male patients with IBD.http://www.irjournal.org/upload/pdf/ir-2021-00042.pdfprimary sclerosing cholangitisinflammatory bowel diseaseulcerative colitis |
| spellingShingle | Meng-Tzu Weng I-Lun Shih Chien-Chih Tung Yew-Loong Leong Ming-Jium Shieh Cheng-Yi Wang Jau-Min Wong Yen-Hsuan Ni Shu-Chen Wei Association of young age and male sex with primary sclerosing cholangitis in Taiwanese patients with inflammatory bowel disease Intestinal Research primary sclerosing cholangitis inflammatory bowel disease ulcerative colitis |
| title | Association of young age and male sex with primary sclerosing cholangitis in Taiwanese patients with inflammatory bowel disease |
| title_full | Association of young age and male sex with primary sclerosing cholangitis in Taiwanese patients with inflammatory bowel disease |
| title_fullStr | Association of young age and male sex with primary sclerosing cholangitis in Taiwanese patients with inflammatory bowel disease |
| title_full_unstemmed | Association of young age and male sex with primary sclerosing cholangitis in Taiwanese patients with inflammatory bowel disease |
| title_short | Association of young age and male sex with primary sclerosing cholangitis in Taiwanese patients with inflammatory bowel disease |
| title_sort | association of young age and male sex with primary sclerosing cholangitis in taiwanese patients with inflammatory bowel disease |
| topic | primary sclerosing cholangitis inflammatory bowel disease ulcerative colitis |
| url | http://www.irjournal.org/upload/pdf/ir-2021-00042.pdf |
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