Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for Health
Nanotechnology is a field of research that has been stressed as a very valuable approach for the prevention and treatment of different human health disorders. This has been stressed as a delivery system for the therapeutic fight against an array of pathophysiological situations. Actually, industry h...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-05-01
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| Series: | Foods |
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| Online Access: | http://www.mdpi.com/2304-8158/7/5/72 |
| _version_ | 1819116764599943168 |
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| author | MCarment Martínez-Ballesta Ángel Gil-Izquierdo Cristina García-Viguera Raúl Domínguez-Perles |
| author_facet | MCarment Martínez-Ballesta Ángel Gil-Izquierdo Cristina García-Viguera Raúl Domínguez-Perles |
| author_sort | MCarment Martínez-Ballesta |
| collection | DOAJ |
| description | Nanotechnology is a field of research that has been stressed as a very valuable approach for the prevention and treatment of different human health disorders. This has been stressed as a delivery system for the therapeutic fight against an array of pathophysiological situations. Actually, industry has applied this technology in the search for new oral delivery alternatives obtained upon the modification of the solubility properties of bioactive compounds. Significant works have been made in the last years for testing the input that nanomaterials and nanoparticles provide for an array of pathophysiological situations. In this frame, this review addresses general questions concerning the extent to which nanoparticles offer alternatives that improve therapeutic value, while avoid toxicity, by releasing bioactive compounds specifically to target tissues affected by specific chemical and pathophysiological settings. In this regard, to date, the contribution of nanoparticles to protect encapsulated bioactive compounds from degradation as a result of gastrointestinal digestion and cellular metabolism, to enable their release in a controlled manner, enhancing biodistribution of bioactive compounds, and to allow them to target those tissues affected by biological disturbances has been demonstrated. |
| first_indexed | 2024-12-22T05:22:16Z |
| format | Article |
| id | doaj.art-e71748727cf049c18e7f480df930449a |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-12-22T05:22:16Z |
| publishDate | 2018-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-e71748727cf049c18e7f480df930449a2022-12-21T18:37:42ZengMDPI AGFoods2304-81582018-05-01757210.3390/foods7050072foods7050072Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for HealthMCarment Martínez-Ballesta0Ángel Gil-Izquierdo1Cristina García-Viguera2Raúl Domínguez-Perles3Department of Plant Nutrition, Centro de Edafología y Biología Aplicada del Segura-Spanish Council for Scientific Research (CEBAS-CSIC), Campus de Espinardo 25, 30100 Espinardo, Murcia, SpainResearch Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, Centro de Edafología y Biología Aplicada del Segura-Spanish Council for Scientific Research (CEBAS-CSIC), Campus de Espinardo 25, 30100 Espinardo, Murcia, SpainResearch Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, Centro de Edafología y Biología Aplicada del Segura-Spanish Council for Scientific Research (CEBAS-CSIC), Campus de Espinardo 25, 30100 Espinardo, Murcia, SpainResearch Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, Centro de Edafología y Biología Aplicada del Segura-Spanish Council for Scientific Research (CEBAS-CSIC), Campus de Espinardo 25, 30100 Espinardo, Murcia, SpainNanotechnology is a field of research that has been stressed as a very valuable approach for the prevention and treatment of different human health disorders. This has been stressed as a delivery system for the therapeutic fight against an array of pathophysiological situations. Actually, industry has applied this technology in the search for new oral delivery alternatives obtained upon the modification of the solubility properties of bioactive compounds. Significant works have been made in the last years for testing the input that nanomaterials and nanoparticles provide for an array of pathophysiological situations. In this frame, this review addresses general questions concerning the extent to which nanoparticles offer alternatives that improve therapeutic value, while avoid toxicity, by releasing bioactive compounds specifically to target tissues affected by specific chemical and pathophysiological settings. In this regard, to date, the contribution of nanoparticles to protect encapsulated bioactive compounds from degradation as a result of gastrointestinal digestion and cellular metabolism, to enable their release in a controlled manner, enhancing biodistribution of bioactive compounds, and to allow them to target those tissues affected by biological disturbances has been demonstrated.http://www.mdpi.com/2304-8158/7/5/72phytochemicalsnanoparticlescontrolled releaseimproved functionalityhealthsmart-formulations |
| spellingShingle | MCarment Martínez-Ballesta Ángel Gil-Izquierdo Cristina García-Viguera Raúl Domínguez-Perles Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for Health Foods phytochemicals nanoparticles controlled release improved functionality health smart-formulations |
| title | Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for Health |
| title_full | Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for Health |
| title_fullStr | Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for Health |
| title_full_unstemmed | Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for Health |
| title_short | Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for Health |
| title_sort | nanoparticles and controlled delivery for bioactive compounds outlining challenges for new smart foods for health |
| topic | phytochemicals nanoparticles controlled release improved functionality health smart-formulations |
| url | http://www.mdpi.com/2304-8158/7/5/72 |
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