Neohesperidin dihydrochalcone can improve intestinal structure and microflora composition of diabetic zebrafish
This study focused on Neohesperidin dihydrochalcone (NHDC) and explored its effects on the intestinal tissue structure, short-chain fatty acid production, gut microbiota, and intestinal tissue oxidative stress in a diabetic zebrafish model with insulin resistance. By analyzing the relationship betwe...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-04-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624001208 |
| _version_ | 1797256450021523456 |
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| author | Pei Wang Fuying Tao Ziru Dai Tianci Wang Chenxiao Zhang Heliang Fan Mei Qin Cen Qi Ying Li Junguang Hao |
| author_facet | Pei Wang Fuying Tao Ziru Dai Tianci Wang Chenxiao Zhang Heliang Fan Mei Qin Cen Qi Ying Li Junguang Hao |
| author_sort | Pei Wang |
| collection | DOAJ |
| description | This study focused on Neohesperidin dihydrochalcone (NHDC) and explored its effects on the intestinal tissue structure, short-chain fatty acid production, gut microbiota, and intestinal tissue oxidative stress in a diabetic zebrafish model with insulin resistance. By analyzing the relationship between gut microbiota changes and glucose metabolism, it revealed the mechanism through which NHDC improves insulin resistance by modulating the gut microbiota. The results indicate that NHDC intervention has a protective effect on the intestinal barrier in diabetic zebrafish, improving lipid metabolism disturbances, and enhancing intestinal antioxidant capacity. Regarding community diversity, NHDC treatment increased the diversity and richness of the gut microbiota in diabetic zebrafish. In terms of gut microbiota composition, NHDC treatment reduced the abundance of the inflammation-associated Proteobacteria while increasing the relative abundance of the Fusobacteria, thereby maintaining the stability of the zebrafish gut microbiota. Furthermore, NHDC treatment also increased the abundance of the Prevotella, which is beneficial for increasing glycogen storage and inhibiting liver gluconeogenesis. Therefore, we speculate that NHDC may regulate the production of SCFAs and reduce the expression levels of pro-inflammatory cytokines by reducing the abundance of harmful bacteria such as Proteobacteria, Plesiomonas, and Aeromonas, while increasing the abundance of Faecalibacterium and Fusobacteria. The changes in the abundance of these microbiota members are involved in processes such as inflammation stress, glycogen storage, and gluconeogenesis, collectively promoting the improvement of insulin resistance in diabetic zebrafish by NHDC. |
| first_indexed | 2024-03-07T14:02:31Z |
| format | Article |
| id | doaj.art-e719f495517644fbba0e78a687a59b86 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-24T22:21:56Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-e719f495517644fbba0e78a687a59b862024-03-20T06:09:08ZengElsevierJournal of Functional Foods1756-46462024-04-01115106118Neohesperidin dihydrochalcone can improve intestinal structure and microflora composition of diabetic zebrafishPei Wang0Fuying Tao1Ziru Dai2Tianci Wang3Chenxiao Zhang4Heliang Fan5Mei Qin6Cen Qi7Ying Li8Junguang Hao9Guangxi College and University Key Laboratory of High-value Utilization of Seafood and Prepared Food in Beibu Gulf, Beibu Gulf University, China; Qinzhou Key Laboratory of Food Flavor Analysis and Control, Beibu Gulf University, ChinaGuangxi College and University Key Laboratory of High-value Utilization of Seafood and Prepared Food in Beibu Gulf, Beibu Gulf University, China; Qinzhou Key Laboratory of Food Flavor Analysis and Control, Beibu Gulf University, ChinaGuangxi College and University Key Laboratory of High-value Utilization of Seafood and Prepared Food in Beibu Gulf, Beibu Gulf University, China; Qinzhou Key Laboratory of Food Flavor Analysis and Control, Beibu Gulf University, China; Corresponding author at: Guangxi College and University Key Laboratory of High-value Utilization of Seafood and Prepared Food in Beibu Gulf, Beibu Gulf University, China.Guangxi College and University Key Laboratory of High-value Utilization of Seafood and Prepared Food in Beibu Gulf, Beibu Gulf University, China; Qinzhou Key Laboratory of Food Flavor Analysis and Control, Beibu Gulf University, ChinaGuangxi College and University Key Laboratory of High-value Utilization of Seafood and Prepared Food in Beibu Gulf, Beibu Gulf University, China; Qinzhou Key Laboratory of Food Flavor Analysis and Control, Beibu Gulf University, ChinaGuangxi College and University Key Laboratory of High-value Utilization of Seafood and Prepared Food in Beibu Gulf, Beibu Gulf University, China; Qinzhou Key Laboratory of Food Flavor Analysis and Control, Beibu Gulf University, ChinaGuangxi College and University Key Laboratory of High-value Utilization of Seafood and Prepared Food in Beibu Gulf, Beibu Gulf University, China; Qinzhou Key Laboratory of Food Flavor Analysis and Control, Beibu Gulf University, ChinaGuangxi College and University Key Laboratory of High-value Utilization of Seafood and Prepared Food in Beibu Gulf, Beibu Gulf University, China; Qinzhou Key Laboratory of Food Flavor Analysis and Control, Beibu Gulf University, ChinaGuangxi College and University Key Laboratory of High-value Utilization of Seafood and Prepared Food in Beibu Gulf, Beibu Gulf University, China; Qinzhou Key Laboratory of Food Flavor Analysis and Control, Beibu Gulf University, ChinaGuangxi College and University Key Laboratory of High-value Utilization of Seafood and Prepared Food in Beibu Gulf, Beibu Gulf University, China; Qinzhou Key Laboratory of Food Flavor Analysis and Control, Beibu Gulf University, ChinaThis study focused on Neohesperidin dihydrochalcone (NHDC) and explored its effects on the intestinal tissue structure, short-chain fatty acid production, gut microbiota, and intestinal tissue oxidative stress in a diabetic zebrafish model with insulin resistance. By analyzing the relationship between gut microbiota changes and glucose metabolism, it revealed the mechanism through which NHDC improves insulin resistance by modulating the gut microbiota. The results indicate that NHDC intervention has a protective effect on the intestinal barrier in diabetic zebrafish, improving lipid metabolism disturbances, and enhancing intestinal antioxidant capacity. Regarding community diversity, NHDC treatment increased the diversity and richness of the gut microbiota in diabetic zebrafish. In terms of gut microbiota composition, NHDC treatment reduced the abundance of the inflammation-associated Proteobacteria while increasing the relative abundance of the Fusobacteria, thereby maintaining the stability of the zebrafish gut microbiota. Furthermore, NHDC treatment also increased the abundance of the Prevotella, which is beneficial for increasing glycogen storage and inhibiting liver gluconeogenesis. Therefore, we speculate that NHDC may regulate the production of SCFAs and reduce the expression levels of pro-inflammatory cytokines by reducing the abundance of harmful bacteria such as Proteobacteria, Plesiomonas, and Aeromonas, while increasing the abundance of Faecalibacterium and Fusobacteria. The changes in the abundance of these microbiota members are involved in processes such as inflammation stress, glycogen storage, and gluconeogenesis, collectively promoting the improvement of insulin resistance in diabetic zebrafish by NHDC.http://www.sciencedirect.com/science/article/pii/S1756464624001208Neohesperidin dihydrochalconeDiabetic zebrafishGut microbiotaInsulin resistance |
| spellingShingle | Pei Wang Fuying Tao Ziru Dai Tianci Wang Chenxiao Zhang Heliang Fan Mei Qin Cen Qi Ying Li Junguang Hao Neohesperidin dihydrochalcone can improve intestinal structure and microflora composition of diabetic zebrafish Journal of Functional Foods Neohesperidin dihydrochalcone Diabetic zebrafish Gut microbiota Insulin resistance |
| title | Neohesperidin dihydrochalcone can improve intestinal structure and microflora composition of diabetic zebrafish |
| title_full | Neohesperidin dihydrochalcone can improve intestinal structure and microflora composition of diabetic zebrafish |
| title_fullStr | Neohesperidin dihydrochalcone can improve intestinal structure and microflora composition of diabetic zebrafish |
| title_full_unstemmed | Neohesperidin dihydrochalcone can improve intestinal structure and microflora composition of diabetic zebrafish |
| title_short | Neohesperidin dihydrochalcone can improve intestinal structure and microflora composition of diabetic zebrafish |
| title_sort | neohesperidin dihydrochalcone can improve intestinal structure and microflora composition of diabetic zebrafish |
| topic | Neohesperidin dihydrochalcone Diabetic zebrafish Gut microbiota Insulin resistance |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624001208 |
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