Sildenafil Use in the Treatment of Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: A Case Series
Abstract Objective This article studies the role of sildenafil in reducing myocardial stress (measured by serial N-terminal pro b-type natriuretic peptide [NTproBNP] levels) secondary to bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH). Study Design Thi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2018-10-01
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| Series: | American Journal of Perinatology Reports |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1673343 |
| _version_ | 1818041532319531008 |
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| author | Amna Qasim Soham Dasgupta Ashraf M. Aly Sunil K. Jain |
| author_facet | Amna Qasim Soham Dasgupta Ashraf M. Aly Sunil K. Jain |
| author_sort | Amna Qasim |
| collection | DOAJ |
| description | Abstract
Objective This article studies the role of sildenafil in reducing myocardial stress (measured by serial N-terminal pro b-type natriuretic peptide [NTproBNP] levels) secondary to bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH).
Study Design This is a case series of three extremely low birth weight infants with severe BPD at 36 weeks' postmenstrual age. All infants had very elevated NTproBNP (> 2,000 ng/dL) levels and echocardiographic evidence of BPD-PH. Sildenafil was started and infants were followed up every 2 weeks clinically along with NTproBNP levels and echocardiograms.
Results After 4 weeks of sildenafil treatment, NTproBNP levels decreased significantly in all infants, echocardiograms showed significant improvement in one infant, and respiratory severity score improved significantly in one infant. All infants tolerated sildenafil.
Conclusion Sildenafil reduced NTproBNP levels in all infants with BPD-PH but the echocardiographic findings and respiratory scores did not improve consistently. We speculate that this may be due to a delay in diagnosis and initiation of therapy after irreversible pulmonary changes have set in. |
| first_indexed | 2024-12-10T08:31:55Z |
| format | Article |
| id | doaj.art-e71b4e2bb1c540318c58e40d165514cf |
| institution | Directory Open Access Journal |
| issn | 2157-6998 2157-7005 |
| language | English |
| last_indexed | 2024-12-10T08:31:55Z |
| publishDate | 2018-10-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | American Journal of Perinatology Reports |
| spelling | doaj.art-e71b4e2bb1c540318c58e40d165514cf2022-12-22T01:56:05ZengThieme Medical Publishers, Inc.American Journal of Perinatology Reports2157-69982157-70052018-10-010804e219e22210.1055/s-0038-1673343Sildenafil Use in the Treatment of Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: A Case SeriesAmna Qasim0Soham Dasgupta1Ashraf M. Aly2Sunil K. Jain3Department of Pediatrics, University of Texas Medical Branch, Galveston, TexasDepartment of Pediatrics, University of Texas Medical Branch, Galveston, TexasDivision of Pediatric Cardiology, University of Texas Medical Branch, Galveston, TexasDivision of Neonatology, University of Texas Medical Branch, Galveston, TexasAbstract Objective This article studies the role of sildenafil in reducing myocardial stress (measured by serial N-terminal pro b-type natriuretic peptide [NTproBNP] levels) secondary to bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH). Study Design This is a case series of three extremely low birth weight infants with severe BPD at 36 weeks' postmenstrual age. All infants had very elevated NTproBNP (> 2,000 ng/dL) levels and echocardiographic evidence of BPD-PH. Sildenafil was started and infants were followed up every 2 weeks clinically along with NTproBNP levels and echocardiograms. Results After 4 weeks of sildenafil treatment, NTproBNP levels decreased significantly in all infants, echocardiograms showed significant improvement in one infant, and respiratory severity score improved significantly in one infant. All infants tolerated sildenafil. Conclusion Sildenafil reduced NTproBNP levels in all infants with BPD-PH but the echocardiographic findings and respiratory scores did not improve consistently. We speculate that this may be due to a delay in diagnosis and initiation of therapy after irreversible pulmonary changes have set in.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1673343bronchopulmonary dysplasiapulmonary hypertensionpulmonary vasodilatorntprobnp |
| spellingShingle | Amna Qasim Soham Dasgupta Ashraf M. Aly Sunil K. Jain Sildenafil Use in the Treatment of Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: A Case Series American Journal of Perinatology Reports bronchopulmonary dysplasia pulmonary hypertension pulmonary vasodilator ntprobnp |
| title | Sildenafil Use in the Treatment of Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: A Case Series |
| title_full | Sildenafil Use in the Treatment of Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: A Case Series |
| title_fullStr | Sildenafil Use in the Treatment of Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: A Case Series |
| title_full_unstemmed | Sildenafil Use in the Treatment of Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: A Case Series |
| title_short | Sildenafil Use in the Treatment of Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: A Case Series |
| title_sort | sildenafil use in the treatment of bronchopulmonary dysplasia associated pulmonary hypertension a case series |
| topic | bronchopulmonary dysplasia pulmonary hypertension pulmonary vasodilator ntprobnp |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1673343 |
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