COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan
Abstract The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or its mutated varian...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-12-01
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| Series: | Cell Discovery |
| Online Access: | https://doi.org/10.1038/s41421-022-00496-x |
| _version_ | 1828121199249457152 |
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| author | Hong Liang Xuanxuan Nian Junzheng Wu Dong Liu Lu Feng Jia Lu Yan Peng Zhijun Zhou Tao Deng Jing Liu Deming Ji Ran Qiu Lianzhen Lin Yan Zeng Fei Xia Yong Hu Taojing Li Kai Duan Xinguo Li Zejun Wang Yong Zhang Hang Zhang Chen Zhu Shang Wang Xiao Wu Xiang Wang Yuwei Li Shihe Huang Min Mao Huanhuan Guo Yunkai Yang Rui Jia Jingwei Xufang Xuewei Wang Shuyan Liang Zhixin Qiu Juan Zhang Yaling Ding Chunyan Li Jin Zhang Daoxing Fu Yanlin He Dongbo Zhou Cesheng Li Jiayou Zhang Ding Yu Xiao-Ming Yang |
| author_facet | Hong Liang Xuanxuan Nian Junzheng Wu Dong Liu Lu Feng Jia Lu Yan Peng Zhijun Zhou Tao Deng Jing Liu Deming Ji Ran Qiu Lianzhen Lin Yan Zeng Fei Xia Yong Hu Taojing Li Kai Duan Xinguo Li Zejun Wang Yong Zhang Hang Zhang Chen Zhu Shang Wang Xiao Wu Xiang Wang Yuwei Li Shihe Huang Min Mao Huanhuan Guo Yunkai Yang Rui Jia Jingwei Xufang Xuewei Wang Shuyan Liang Zhixin Qiu Juan Zhang Yaling Ding Chunyan Li Jin Zhang Daoxing Fu Yanlin He Dongbo Zhou Cesheng Li Jiayou Zhang Ding Yu Xiao-Ming Yang |
| author_sort | Hong Liang |
| collection | DOAJ |
| description | Abstract The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or its mutated variants. Here, we report that the inactivated COVID-19 vaccine can stimulate immunity in recovered patients to maintain high levels of anti-receptor-binding domain (RBD) and anti-nucleocapsid protein (NP) antibody titers within 9 months, and high neutralizing activity against the prototype, Delta, and Omicron strains was observed. Nevertheless, the antibody response decreased over time, and the Omicron variant exhibited more pronounced resistance to neutralization than the prototype and Delta strains. Moreover, the intensity of the SARS-CoV-2-specific CD4+ T cell response was also increased in recovered patients who received COVID-19 vaccines. Overall, the repeated antigen exposure provided by inactivated COVID-19 vaccination greatly boosted both the potency and breadth of the humoral and cellular immune responses against SARS-CoV-2, effectively protecting recovered individuals from reinfection by circulating SARS-CoV-2 and its variants. |
| first_indexed | 2024-04-11T14:16:58Z |
| format | Article |
| id | doaj.art-e71bae845a314b169b4bf8300c2580e3 |
| institution | Directory Open Access Journal |
| issn | 2056-5968 |
| language | English |
| last_indexed | 2024-04-11T14:16:58Z |
| publishDate | 2022-12-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Discovery |
| spelling | doaj.art-e71bae845a314b169b4bf8300c2580e32022-12-22T04:19:23ZengNature Publishing GroupCell Discovery2056-59682022-12-018111410.1038/s41421-022-00496-xCOVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in WuhanHong Liang0Xuanxuan Nian1Junzheng Wu2Dong Liu3Lu Feng4Jia Lu5Yan Peng6Zhijun Zhou7Tao Deng8Jing Liu9Deming Ji10Ran Qiu11Lianzhen Lin12Yan Zeng13Fei Xia14Yong Hu15Taojing Li16Kai Duan17Xinguo Li18Zejun Wang19Yong Zhang20Hang Zhang21Chen Zhu22Shang Wang23Xiao Wu24Xiang Wang25Yuwei Li26Shihe Huang27Min Mao28Huanhuan Guo29Yunkai Yang30Rui Jia31Jingwei Xufang32Xuewei Wang33Shuyan Liang34Zhixin Qiu35Juan Zhang36Yaling Ding37Chunyan Li38Jin Zhang39Daoxing Fu40Yanlin He41Dongbo Zhou42Cesheng Li43Jiayou Zhang44Ding Yu45Xiao-Ming Yang46Beijing Tiantan Biological Products Co., Ltd.National Engineering Technology Research Center for Combined VaccinesChengdu Rongsheng Pharmaceuticals Co., Ltd.Beijing Tiantan Biological Products Co., Ltd.Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd.National Engineering Technology Research Center for Combined VaccinesSinopharm Wuhan Plasma-derived Biotherapies Co., Ltd.Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd.National Engineering Technology Research Center for Combined VaccinesNational Engineering Technology Research Center for Combined VaccinesSinopharm Wuhan Plasma-derived Biotherapies Co., Ltd.National Engineering Technology Research Center for Combined VaccinesSinopharm Wuhan Plasma-derived Biotherapies Co., Ltd.National Engineering Technology Research Center for Combined VaccinesNational Engineering Technology Research Center for Combined VaccinesSinopharm Wuhan Plasma-derived Biotherapies Co., Ltd.Beijing Tiantan Biological Products Co., Ltd.National Engineering Technology Research Center for Combined VaccinesNational Engineering Technology Research Center for Combined VaccinesNational Engineering Technology Research Center for Combined VaccinesBeijing Tiantan Biological Products Co., Ltd.Beijing Tiantan Biological Products Co., Ltd.Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd.Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd.Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd.National Engineering Technology Research Center for Combined VaccinesNational Engineering Technology Research Center for Combined VaccinesNational Engineering Technology Research Center for Combined VaccinesSinopharm Wuhan Plasma-derived Biotherapies Co., Ltd.Wuxue Wusheng Plasma Collection CenterChina National Biotec Group Company LimitedChina National Biotec Group Company LimitedChina National Biotec Group Company LimitedChina National Biotec Group Company LimitedWuhan Biobank Co., Ltd.Wuhan Biobank Co., Ltd.Wuhan Biobank Co., Ltd.Chengdu Rongsheng Pharmaceuticals Co., Ltd.Beijing Tiantan Biological Products Co., Ltd.Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd.Beijing Tiantan Biological Products Co., Ltd.Beijing Tiantan Biological Products Co., Ltd.Beijing Tiantan Biological Products Co., Ltd.Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd.National Engineering Technology Research Center for Combined VaccinesBeijing Tiantan Biological Products Co., Ltd.National Engineering Technology Research Center for Combined VaccinesAbstract The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or its mutated variants. Here, we report that the inactivated COVID-19 vaccine can stimulate immunity in recovered patients to maintain high levels of anti-receptor-binding domain (RBD) and anti-nucleocapsid protein (NP) antibody titers within 9 months, and high neutralizing activity against the prototype, Delta, and Omicron strains was observed. Nevertheless, the antibody response decreased over time, and the Omicron variant exhibited more pronounced resistance to neutralization than the prototype and Delta strains. Moreover, the intensity of the SARS-CoV-2-specific CD4+ T cell response was also increased in recovered patients who received COVID-19 vaccines. Overall, the repeated antigen exposure provided by inactivated COVID-19 vaccination greatly boosted both the potency and breadth of the humoral and cellular immune responses against SARS-CoV-2, effectively protecting recovered individuals from reinfection by circulating SARS-CoV-2 and its variants.https://doi.org/10.1038/s41421-022-00496-x |
| spellingShingle | Hong Liang Xuanxuan Nian Junzheng Wu Dong Liu Lu Feng Jia Lu Yan Peng Zhijun Zhou Tao Deng Jing Liu Deming Ji Ran Qiu Lianzhen Lin Yan Zeng Fei Xia Yong Hu Taojing Li Kai Duan Xinguo Li Zejun Wang Yong Zhang Hang Zhang Chen Zhu Shang Wang Xiao Wu Xiang Wang Yuwei Li Shihe Huang Min Mao Huanhuan Guo Yunkai Yang Rui Jia Jingwei Xufang Xuewei Wang Shuyan Liang Zhixin Qiu Juan Zhang Yaling Ding Chunyan Li Jin Zhang Daoxing Fu Yanlin He Dongbo Zhou Cesheng Li Jiayou Zhang Ding Yu Xiao-Ming Yang COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan Cell Discovery |
| title | COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan |
| title_full | COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan |
| title_fullStr | COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan |
| title_full_unstemmed | COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan |
| title_short | COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan |
| title_sort | covid 19 vaccination boosts the potency and breadth of the immune response against sars cov 2 among recovered patients in wuhan |
| url | https://doi.org/10.1038/s41421-022-00496-x |
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