Effect of Flavonoid-Coated Gold Nanoparticles on Bacterial Colonization in Mice Organs
Multidrug resistance (MDR) has been a potentiator for the exploration of antibiotics. Nano drug delivery systems have opened new avenues to overcome this challenge. Although antibacterial nanocarriers are extensively realized, their effect on the bacteria residing inside the tissues and their toxici...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/10/9/1769 |
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| author | Sundus Riaz Nosheen Fatima Rana Irshad Hussain Tahreem Tanweer Afrah Nawaz Farid Menaa Hussnain A. Janjua Tahseen Alam Amna Batool Ayesha Naeem Maryam Hameed Syed Mohsin Ali |
| author_facet | Sundus Riaz Nosheen Fatima Rana Irshad Hussain Tahreem Tanweer Afrah Nawaz Farid Menaa Hussnain A. Janjua Tahseen Alam Amna Batool Ayesha Naeem Maryam Hameed Syed Mohsin Ali |
| author_sort | Sundus Riaz |
| collection | DOAJ |
| description | Multidrug resistance (MDR) has been a potentiator for the exploration of antibiotics. Nano drug delivery systems have opened new avenues to overcome this challenge. Although antibacterial nanocarriers are extensively realized, their effect on the bacteria residing inside the tissues and their toxicity is rarely explored. This study investigated the effects of flavonoid coated gold nanoparticles (FAuNPs) on the colonization of <i>Enterococcus faecalis</i> in the mouse liver and kidneys. Flavonoids were extracted from the leaves of <i>Berberis lycium</i> Royle and used to stabilize gold following a green synthesis approach. FAuNPs were characterized by ultraviolet-visible (UV-Vis) spectroscopy, Fourier-transform infrared spectroscopy (FTIR), scanning transmission electron microscopy (STEM), X-ray powder diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDS). FAuNPs showed significantly higher reduction in bacterial counts in in-vitro and in-vivo in mice organs as compared to the free flavonoids owing to their biocompatibility and effectiveness. |
| first_indexed | 2024-03-10T16:31:11Z |
| format | Article |
| id | doaj.art-e71d9695e9d24fd5b9c5bc51a0db5313 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T16:31:11Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-e71d9695e9d24fd5b9c5bc51a0db53132023-11-20T12:53:48ZengMDPI AGNanomaterials2079-49912020-09-01109176910.3390/nano10091769Effect of Flavonoid-Coated Gold Nanoparticles on Bacterial Colonization in Mice OrgansSundus Riaz0Nosheen Fatima Rana1Irshad Hussain2Tahreem Tanweer3Afrah Nawaz4Farid Menaa5Hussnain A. Janjua6Tahseen Alam7Amna Batool8Ayesha Naeem9Maryam Hameed10Syed Mohsin Ali11Department of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences & Technology, Islamabad 44000, PakistanDepartment of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences & Technology, Islamabad 44000, PakistanSchool of Science and Engineering, Lahore University of Management Sciences, Lahore 54000, PakistanDepartment of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences & Technology, Islamabad 44000, PakistanDepartment of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences & Technology, Islamabad 44000, PakistanDepartment of Internal Medicine and Nanomedicine, California Innovations Corporation, San Diego, CA 92093, USAAtta Ur Rahman School of Applied Biosciences, National University of Sciences & Technology, Islamabad 44000, PakistanAtta Ur Rahman School of Applied Biosciences, National University of Sciences & Technology, Islamabad 44000, PakistanDepartment of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences & Technology, Islamabad 44000, PakistanDepartment of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences & Technology, Islamabad 44000, PakistanDepartment of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences & Technology, Islamabad 44000, PakistanDepartment of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences & Technology, Islamabad 44000, PakistanMultidrug resistance (MDR) has been a potentiator for the exploration of antibiotics. Nano drug delivery systems have opened new avenues to overcome this challenge. Although antibacterial nanocarriers are extensively realized, their effect on the bacteria residing inside the tissues and their toxicity is rarely explored. This study investigated the effects of flavonoid coated gold nanoparticles (FAuNPs) on the colonization of <i>Enterococcus faecalis</i> in the mouse liver and kidneys. Flavonoids were extracted from the leaves of <i>Berberis lycium</i> Royle and used to stabilize gold following a green synthesis approach. FAuNPs were characterized by ultraviolet-visible (UV-Vis) spectroscopy, Fourier-transform infrared spectroscopy (FTIR), scanning transmission electron microscopy (STEM), X-ray powder diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDS). FAuNPs showed significantly higher reduction in bacterial counts in in-vitro and in-vivo in mice organs as compared to the free flavonoids owing to their biocompatibility and effectiveness.https://www.mdpi.com/2079-4991/10/9/1769flavonoids<i>Berberis lycium</i><i>Enterococcus faecalis</i>drug deliveryinfectious diseases |
| spellingShingle | Sundus Riaz Nosheen Fatima Rana Irshad Hussain Tahreem Tanweer Afrah Nawaz Farid Menaa Hussnain A. Janjua Tahseen Alam Amna Batool Ayesha Naeem Maryam Hameed Syed Mohsin Ali Effect of Flavonoid-Coated Gold Nanoparticles on Bacterial Colonization in Mice Organs Nanomaterials flavonoids <i>Berberis lycium</i> <i>Enterococcus faecalis</i> drug delivery infectious diseases |
| title | Effect of Flavonoid-Coated Gold Nanoparticles on Bacterial Colonization in Mice Organs |
| title_full | Effect of Flavonoid-Coated Gold Nanoparticles on Bacterial Colonization in Mice Organs |
| title_fullStr | Effect of Flavonoid-Coated Gold Nanoparticles on Bacterial Colonization in Mice Organs |
| title_full_unstemmed | Effect of Flavonoid-Coated Gold Nanoparticles on Bacterial Colonization in Mice Organs |
| title_short | Effect of Flavonoid-Coated Gold Nanoparticles on Bacterial Colonization in Mice Organs |
| title_sort | effect of flavonoid coated gold nanoparticles on bacterial colonization in mice organs |
| topic | flavonoids <i>Berberis lycium</i> <i>Enterococcus faecalis</i> drug delivery infectious diseases |
| url | https://www.mdpi.com/2079-4991/10/9/1769 |
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