Screening potential P-glycoprotein inhibitors by combination of a detergent-free membrane protein extraction with surface plasmon resonance biosensor

Screening potential P-glycoprotein inhibitors by combination of a detergent-free membrane protein extraction with surface plasmon resonance biosensor

P-glycoprotein (P-gp) highly expressed in cancer cells can lead to multidrug resistance (MDR) and the combination of anti-cancer drugs with P-gp inhibitor has been a promising strategy to reverse MDR in cancer treatment. In this study, we established a label-free and detergent-free system combining...

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Bibliographic Details
Main Authors:	Yuhong Cao, Jiahao Fang, Yiwei Shi, Hui Wang, Xiaofei Chen, Yue Liu, Zhenyu Zhu, Yan Cao, Zhanying Hong, Yifeng Chai
Format:	Article
Language:	English
Published:	Elsevier 2022-07-01
Series:	Acta Pharmaceutica Sinica B
Subjects:	Styrene maleic acid P-Glycoprotein Surface plasmon resonance Membrane proteins Inhibitor screening Affinity calculation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383522001460

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