Nsp1 facilitates SARS-CoV-2 replication through calcineurin-NFAT signaling

Nsp1 facilitates SARS-CoV-2 replication through calcineurin-NFAT signaling

ABSTRACTSARS-CoV-2, the causative agent of COVID-19, has been intensely studied in search of effective antiviral treatments. The immunosuppressant cyclosporine A (CsA) has been suggested to be a pan-coronavirus inhibitor, yet its underlying mechanism remained largely unknown. Here, we found that non...

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Bibliographic Details
Main Authors: Wai-Yin Lui, Chon Phin Ong, Pak-Hin Hinson Cheung, Zi-Wei Ye, Chi-Ping Chan, Kelvin Kai-Wang To, Kit-San Yuen, Dong-Yan Jin
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:mBio
Subjects:
SARS-CoV-2
Nsp1
calcineurin
NFAT
RCAN3
DDX5
Online Access:https://journals.asm.org/doi/10.1128/mbio.00392-24

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