The Evaluation of Contrast-to-Noise Ratio in CT Images Using Different Parameters of Gold Nanoparticles versus Omnipaque
Purpose: Gold Nanoparticles (GNPs) with high density and an atomic number have lately been proposed as an alternative contrast agent for Computed Tomography (CT). Materials and Methods: In the present study, the Contrast-to-Noise Ratio (CNR) of GNPs from various shapes, sizes, concentrations, an...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2022-03-01
|
| Series: | Frontiers in Biomedical Technologies |
| Subjects: | |
| Online Access: | https://fbt.tums.ac.ir/index.php/fbt/article/view/428 |
| _version_ | 1798031906977087488 |
|---|---|
| author | Sara Khademi Hosein Azimian Hossein Ghadiri |
| author_facet | Sara Khademi Hosein Azimian Hossein Ghadiri |
| author_sort | Sara Khademi |
| collection | DOAJ |
| description |
Purpose: Gold Nanoparticles (GNPs) with high density and an atomic number have lately been proposed as an alternative contrast agent for Computed Tomography (CT).
Materials and Methods: In the present study, the Contrast-to-Noise Ratio (CNR) of GNPs from various shapes, sizes, concentrations, and surface chemistry was compared with an iodine contrast agent using CT at different X-ray tube voltages and concentrations.
Results: Our findings showed that GNPs in various concentrations, shapes, sizes, and X-ray tube energies from 80 to 140 kVp revealed greater image CNR than iodinated contrast media (Omnipaque). Smaller spherical GNPs (13 nm) had greater CNR than larger ones (60 nm) and Gold Nanorods )GNRs( with a larger Aspect Ratio (AR) represented excellent effect on CNR. In addition, Polyethylene Glycol (PEG) covering on GNRs decreased CNR. We observed image CNR was increased using increasing in kVp and concentration.
Conclusion: Smaller spherical GNPs can be proposed as a potential candidate as a future contrast agent alternative to iodinated contrast media.
|
| first_indexed | 2024-04-11T20:04:10Z |
| format | Article |
| id | doaj.art-e720164a4ac0409082160527a761d01b |
| institution | Directory Open Access Journal |
| issn | 2345-5837 |
| language | English |
| last_indexed | 2024-04-11T20:04:10Z |
| publishDate | 2022-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Frontiers in Biomedical Technologies |
| spelling | doaj.art-e720164a4ac0409082160527a761d01b2022-12-22T04:05:25ZengTehran University of Medical SciencesFrontiers in Biomedical Technologies2345-58372022-03-019410.18502/fbt.v9i4.10420The Evaluation of Contrast-to-Noise Ratio in CT Images Using Different Parameters of Gold Nanoparticles versus OmnipaqueSara Khademi0Hosein Azimian1Hossein Ghadiri2Mashhad University of Medical Sciences, Mashhad, IranMashhad University of Medical Sciences, Mashhad, IranTehran University of Medical Sciences, Tehran, Iran Purpose: Gold Nanoparticles (GNPs) with high density and an atomic number have lately been proposed as an alternative contrast agent for Computed Tomography (CT). Materials and Methods: In the present study, the Contrast-to-Noise Ratio (CNR) of GNPs from various shapes, sizes, concentrations, and surface chemistry was compared with an iodine contrast agent using CT at different X-ray tube voltages and concentrations. Results: Our findings showed that GNPs in various concentrations, shapes, sizes, and X-ray tube energies from 80 to 140 kVp revealed greater image CNR than iodinated contrast media (Omnipaque). Smaller spherical GNPs (13 nm) had greater CNR than larger ones (60 nm) and Gold Nanorods )GNRs( with a larger Aspect Ratio (AR) represented excellent effect on CNR. In addition, Polyethylene Glycol (PEG) covering on GNRs decreased CNR. We observed image CNR was increased using increasing in kVp and concentration. Conclusion: Smaller spherical GNPs can be proposed as a potential candidate as a future contrast agent alternative to iodinated contrast media. https://fbt.tums.ac.ir/index.php/fbt/article/view/428Gold NanoparticlesContrast-to-Noise RatioIodinated Contrast MediaComputed Tomography |
| spellingShingle | Sara Khademi Hosein Azimian Hossein Ghadiri The Evaluation of Contrast-to-Noise Ratio in CT Images Using Different Parameters of Gold Nanoparticles versus Omnipaque Frontiers in Biomedical Technologies Gold Nanoparticles Contrast-to-Noise Ratio Iodinated Contrast Media Computed Tomography |
| title | The Evaluation of Contrast-to-Noise Ratio in CT Images Using Different Parameters of Gold Nanoparticles versus Omnipaque |
| title_full | The Evaluation of Contrast-to-Noise Ratio in CT Images Using Different Parameters of Gold Nanoparticles versus Omnipaque |
| title_fullStr | The Evaluation of Contrast-to-Noise Ratio in CT Images Using Different Parameters of Gold Nanoparticles versus Omnipaque |
| title_full_unstemmed | The Evaluation of Contrast-to-Noise Ratio in CT Images Using Different Parameters of Gold Nanoparticles versus Omnipaque |
| title_short | The Evaluation of Contrast-to-Noise Ratio in CT Images Using Different Parameters of Gold Nanoparticles versus Omnipaque |
| title_sort | evaluation of contrast to noise ratio in ct images using different parameters of gold nanoparticles versus omnipaque |
| topic | Gold Nanoparticles Contrast-to-Noise Ratio Iodinated Contrast Media Computed Tomography |
| url | https://fbt.tums.ac.ir/index.php/fbt/article/view/428 |
| work_keys_str_mv | AT sarakhademi theevaluationofcontrasttonoiseratioinctimagesusingdifferentparametersofgoldnanoparticlesversusomnipaque AT hoseinazimian theevaluationofcontrasttonoiseratioinctimagesusingdifferentparametersofgoldnanoparticlesversusomnipaque AT hosseinghadiri theevaluationofcontrasttonoiseratioinctimagesusingdifferentparametersofgoldnanoparticlesversusomnipaque AT sarakhademi evaluationofcontrasttonoiseratioinctimagesusingdifferentparametersofgoldnanoparticlesversusomnipaque AT hoseinazimian evaluationofcontrasttonoiseratioinctimagesusingdifferentparametersofgoldnanoparticlesversusomnipaque AT hosseinghadiri evaluationofcontrasttonoiseratioinctimagesusingdifferentparametersofgoldnanoparticlesversusomnipaque |