The association between liver fibrosis scores and chronic kidney disease
PurposeThis study aimed to clarify the relationship between liver fibrosis scores (Fibrosis-4, BARD score, and BAAT score) and chronic kidney disease (CKD).MethodsWe collected a range of data from 11,503 subjects (5,326 men and 6,177 women) from the rural regions of Northeastern China. Three liver f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1046825/full |
| _version_ | 1811175431047479296 |
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| author | Shengjun Xiong Pengbo Wang Shizhang Yin Wanshu Deng Yuanhui Zhao Wenhang Li Zhao Li Ying Zhou Shasha Yu Hongmei Yang Xiaofan Guo Yingxian Sun |
| author_facet | Shengjun Xiong Pengbo Wang Shizhang Yin Wanshu Deng Yuanhui Zhao Wenhang Li Zhao Li Ying Zhou Shasha Yu Hongmei Yang Xiaofan Guo Yingxian Sun |
| author_sort | Shengjun Xiong |
| collection | DOAJ |
| description | PurposeThis study aimed to clarify the relationship between liver fibrosis scores (Fibrosis-4, BARD score, and BAAT score) and chronic kidney disease (CKD).MethodsWe collected a range of data from 11,503 subjects (5,326 men and 6,177 women) from the rural regions of Northeastern China. Three liver fibrosis scores (LFSs) including fibrosis-4 (FIB-4), BARD score, and BAAT score were adopted. A logistic regression analysis was used to calculate odds ratios and the 95% confidence interval. A subgroup analysis showed the association between LFSs and CKD under different stratifications. Restricted cubic spline could further explore whether there is a linear relationship between LFSs and CKD. Finally, we used C-statistics, Net Reclassification Index (NRI), and Integrated Discrimination Improvement (IDI) to assess the effect of each LFS on CKD.ResultsThrough the baseline characteristics, we observed that LFSs were higher in the CKD population than in non-CKD. The proportion of participants with CKD also increased with LFSs. In a multivariate logistic regression analysis, the ORs of CKD were 6.71 (4.45–10.13) in FIB-4, 1.88 (1.29–2.75) in the BAAT score, and 1.72 (1.28–2.31) in the BARD score by comparing the high level with the low level in each LFSs. Moreover, after adding LFSs to the original risk prediction model, which consisted of age, sex, drinking, smoking, diabetes, low-density lipoprotein cholesterol, total cholesterol, triglycerides, and mean waist circumference, we found the new models have higher C-statistics. Furthermore, NRI and IDI both indicate LFSs had a positive effect on the model.ConclusionsOur study showed that LFSs are associated with CKD among middle-aged populations in rural areas of northeastern China. |
| first_indexed | 2024-04-10T19:36:03Z |
| format | Article |
| id | doaj.art-e7205285284f425fb44ad572ba1957da |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-10T19:36:03Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-e7205285284f425fb44ad572ba1957da2023-01-30T07:01:10ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-01-011010.3389/fmed.2023.10468251046825The association between liver fibrosis scores and chronic kidney diseaseShengjun XiongPengbo WangShizhang YinWanshu DengYuanhui ZhaoWenhang LiZhao LiYing ZhouShasha YuHongmei YangXiaofan GuoYingxian SunPurposeThis study aimed to clarify the relationship between liver fibrosis scores (Fibrosis-4, BARD score, and BAAT score) and chronic kidney disease (CKD).MethodsWe collected a range of data from 11,503 subjects (5,326 men and 6,177 women) from the rural regions of Northeastern China. Three liver fibrosis scores (LFSs) including fibrosis-4 (FIB-4), BARD score, and BAAT score were adopted. A logistic regression analysis was used to calculate odds ratios and the 95% confidence interval. A subgroup analysis showed the association between LFSs and CKD under different stratifications. Restricted cubic spline could further explore whether there is a linear relationship between LFSs and CKD. Finally, we used C-statistics, Net Reclassification Index (NRI), and Integrated Discrimination Improvement (IDI) to assess the effect of each LFS on CKD.ResultsThrough the baseline characteristics, we observed that LFSs were higher in the CKD population than in non-CKD. The proportion of participants with CKD also increased with LFSs. In a multivariate logistic regression analysis, the ORs of CKD were 6.71 (4.45–10.13) in FIB-4, 1.88 (1.29–2.75) in the BAAT score, and 1.72 (1.28–2.31) in the BARD score by comparing the high level with the low level in each LFSs. Moreover, after adding LFSs to the original risk prediction model, which consisted of age, sex, drinking, smoking, diabetes, low-density lipoprotein cholesterol, total cholesterol, triglycerides, and mean waist circumference, we found the new models have higher C-statistics. Furthermore, NRI and IDI both indicate LFSs had a positive effect on the model.ConclusionsOur study showed that LFSs are associated with CKD among middle-aged populations in rural areas of northeastern China.https://www.frontiersin.org/articles/10.3389/fmed.2023.1046825/fullchronic kidney diseaseliver fibrosis scoresBARD scoreBAAT scorefibrosis-4 |
| spellingShingle | Shengjun Xiong Pengbo Wang Shizhang Yin Wanshu Deng Yuanhui Zhao Wenhang Li Zhao Li Ying Zhou Shasha Yu Hongmei Yang Xiaofan Guo Yingxian Sun The association between liver fibrosis scores and chronic kidney disease Frontiers in Medicine chronic kidney disease liver fibrosis scores BARD score BAAT score fibrosis-4 |
| title | The association between liver fibrosis scores and chronic kidney disease |
| title_full | The association between liver fibrosis scores and chronic kidney disease |
| title_fullStr | The association between liver fibrosis scores and chronic kidney disease |
| title_full_unstemmed | The association between liver fibrosis scores and chronic kidney disease |
| title_short | The association between liver fibrosis scores and chronic kidney disease |
| title_sort | association between liver fibrosis scores and chronic kidney disease |
| topic | chronic kidney disease liver fibrosis scores BARD score BAAT score fibrosis-4 |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1046825/full |
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