Abdominal obesity, excessive adiposity and Taq1B CETP variant are positively associated with serum lipids in Mexican women
Introduction: Obesity is a prevalent multifactorial disease whose main complication is dyslipidemia. Serum lipid levels also depend on genetic factors including the Taq1B variant of the CETP gene, which is suggested to be influenced by environmental factors and adiposity. Therefore, this study aimed...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2023-01-01
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| Series: | Lifestyle Genomics |
| Online Access: | https://www.karger.com/Article/FullText/529053 |
| _version_ | 1797904810087809024 |
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| author | Mariana Perez-Robles Wendy Campos-Perez Joel Torres-Vanegas Sarai Citlalic Rodriguez-Reyes Juan José Rivera-Valdés Erika Martínez-Lopez |
| author_facet | Mariana Perez-Robles Wendy Campos-Perez Joel Torres-Vanegas Sarai Citlalic Rodriguez-Reyes Juan José Rivera-Valdés Erika Martínez-Lopez |
| author_sort | Mariana Perez-Robles |
| collection | DOAJ |
| description | Introduction: Obesity is a prevalent multifactorial disease whose main complication is dyslipidemia. Serum lipid levels also depend on genetic factors including the Taq1B variant of the CETP gene, which is suggested to be influenced by environmental factors and adiposity. Therefore, this study aimed to determine the effect of the Taq1B CETP variant on serum lipid levels associated with anthropometrical variables. Methods: 165 women from Western Mexico were enrolled in this cross-sectional study. Weight and body fat were measured by bioimpedance and waist circumference with a measuring tape. Serum lipid levels were determined by dry chemistry. The Taq1B CETP variant was analyzed by allelic discrimination. Results: Women with abdominal obesity and B1B2/B2B2 genotype had significantly higher total cholesterol levels (195.17 (185.95-204.39) vs 183 mg/dL (169.83-196.16), p = 0.007) and LDL (118.84 (110.65-127.03) vs 113.84 mg/dL (102.37-125.31), p = 0.037) than carriers of B1B1 genotype. Likewise, subjects with excessive adiposity and B1B2/B2B2 genotype showed significantly higher total cholesterol levels (195.05 (186.04-204.06) vs 182.40 mg/dL (169.03-195.76), p = 0.003) than those with B1B1 genotype. Discussion/Conclusion: Women with abdominal obesity or excessive adiposity, who are also carriers of the B1B2/B2B2 genotype have higher serum lipid levels than women with the B1B1 genotype. |
| first_indexed | 2024-04-10T09:54:48Z |
| format | Article |
| id | doaj.art-e721d613dbad4df5a050c1dcdf1218c2 |
| institution | Directory Open Access Journal |
| issn | 2504-3161 2504-3188 |
| language | English |
| last_indexed | 2024-04-10T09:54:48Z |
| publishDate | 2023-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Lifestyle Genomics |
| spelling | doaj.art-e721d613dbad4df5a050c1dcdf1218c22023-02-16T12:58:35ZengKarger PublishersLifestyle Genomics2504-31612504-31882023-01-011110.1159/000529053529053Abdominal obesity, excessive adiposity and Taq1B CETP variant are positively associated with serum lipids in Mexican womenMariana Perez-Robleshttps://orcid.org/0000-0003-2755-1155Wendy Campos-Perezhttps://orcid.org/0000-0003-0483-7599Joel Torres-Vanegashttps://orcid.org/0000-0003-0940-3343Sarai Citlalic Rodriguez-Reyeshttps://orcid.org/0000-0002-7394-4673Juan José Rivera-ValdésErika Martínez-LopezIntroduction: Obesity is a prevalent multifactorial disease whose main complication is dyslipidemia. Serum lipid levels also depend on genetic factors including the Taq1B variant of the CETP gene, which is suggested to be influenced by environmental factors and adiposity. Therefore, this study aimed to determine the effect of the Taq1B CETP variant on serum lipid levels associated with anthropometrical variables. Methods: 165 women from Western Mexico were enrolled in this cross-sectional study. Weight and body fat were measured by bioimpedance and waist circumference with a measuring tape. Serum lipid levels were determined by dry chemistry. The Taq1B CETP variant was analyzed by allelic discrimination. Results: Women with abdominal obesity and B1B2/B2B2 genotype had significantly higher total cholesterol levels (195.17 (185.95-204.39) vs 183 mg/dL (169.83-196.16), p = 0.007) and LDL (118.84 (110.65-127.03) vs 113.84 mg/dL (102.37-125.31), p = 0.037) than carriers of B1B1 genotype. Likewise, subjects with excessive adiposity and B1B2/B2B2 genotype showed significantly higher total cholesterol levels (195.05 (186.04-204.06) vs 182.40 mg/dL (169.03-195.76), p = 0.003) than those with B1B1 genotype. Discussion/Conclusion: Women with abdominal obesity or excessive adiposity, who are also carriers of the B1B2/B2B2 genotype have higher serum lipid levels than women with the B1B1 genotype.https://www.karger.com/Article/FullText/529053 |
| spellingShingle | Mariana Perez-Robles Wendy Campos-Perez Joel Torres-Vanegas Sarai Citlalic Rodriguez-Reyes Juan José Rivera-Valdés Erika Martínez-Lopez Abdominal obesity, excessive adiposity and Taq1B CETP variant are positively associated with serum lipids in Mexican women Lifestyle Genomics |
| title | Abdominal obesity, excessive adiposity and Taq1B CETP variant are positively associated with serum lipids in Mexican women |
| title_full | Abdominal obesity, excessive adiposity and Taq1B CETP variant are positively associated with serum lipids in Mexican women |
| title_fullStr | Abdominal obesity, excessive adiposity and Taq1B CETP variant are positively associated with serum lipids in Mexican women |
| title_full_unstemmed | Abdominal obesity, excessive adiposity and Taq1B CETP variant are positively associated with serum lipids in Mexican women |
| title_short | Abdominal obesity, excessive adiposity and Taq1B CETP variant are positively associated with serum lipids in Mexican women |
| title_sort | abdominal obesity excessive adiposity and taq1b cetp variant are positively associated with serum lipids in mexican women |
| url | https://www.karger.com/Article/FullText/529053 |
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