Effect of abnormal adipose tissue proliferation in thyroid-associated ophthalmopathy
Thyroid-associated ophthalmopathy(TAO)is the most common orbital disease and is a specific autoimmune disorder, of which the etiology and pathogenesis is still unclear. TAO can affect the appearance and visual function of patients, and severe cases can lead to blindness. Tissue currently considered...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2019-11-01
|
| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2019/11/201911014.pdf |
| _version_ | 1818595275664523264 |
|---|---|
| author | Wei Liu Chao Ma Hao-Yu Li Lan Chen Shan-Si Yuan Kai-Jun Li |
| author_facet | Wei Liu Chao Ma Hao-Yu Li Lan Chen Shan-Si Yuan Kai-Jun Li |
| author_sort | Wei Liu |
| collection | DOAJ |
| description | Thyroid-associated ophthalmopathy(TAO)is the most common orbital disease and is a specific autoimmune disorder, of which the etiology and pathogenesis is still unclear. TAO can affect the appearance and visual function of patients, and severe cases can lead to blindness. Tissue currently considered excessive expansion due to orbital fat is formed of one of the key pathological features TAO. The increase of orbital adipose tissue can directly lead to increased retrobulbar pressures and eyeball protrusion. As a new endocrine organ, adipose tissue can secrete a variety of adipocytokines, growth factors and protein molecules, some of which may be involved in the pathogenesis of TAO. The role of abnormal adipose tissue proliferation of TAO is reviewed from the expression of key proteins of adipose differentiation, autophagy, retrobulbar pressure and hypoxia. |
| first_indexed | 2024-12-16T11:13:26Z |
| format | Article |
| id | doaj.art-e72249ce309e42eca3ed6fa11550f671 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-16T11:13:26Z |
| publishDate | 2019-11-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-e72249ce309e42eca3ed6fa11550f6712022-12-21T22:33:40ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232019-11-0119111877188010.3980/j.issn.1672-5123.2019.11.14Effect of abnormal adipose tissue proliferation in thyroid-associated ophthalmopathyWei Liu0Chao Ma1Hao-Yu Li2Lan Chen3Shan-Si Yuan4Kai-Jun Li5Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China; The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, ChinaGuangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China; The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, ChinaGuangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China; The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, ChinaGuangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China; The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, ChinaGuangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China; The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, ChinaGuangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China; The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, ChinaThyroid-associated ophthalmopathy(TAO)is the most common orbital disease and is a specific autoimmune disorder, of which the etiology and pathogenesis is still unclear. TAO can affect the appearance and visual function of patients, and severe cases can lead to blindness. Tissue currently considered excessive expansion due to orbital fat is formed of one of the key pathological features TAO. The increase of orbital adipose tissue can directly lead to increased retrobulbar pressures and eyeball protrusion. As a new endocrine organ, adipose tissue can secrete a variety of adipocytokines, growth factors and protein molecules, some of which may be involved in the pathogenesis of TAO. The role of abnormal adipose tissue proliferation of TAO is reviewed from the expression of key proteins of adipose differentiation, autophagy, retrobulbar pressure and hypoxia.http://ies.ijo.cn/cn_publish/2019/11/201911014.pdfthyroid-associated ophthalmopathyGraves' ophthalmopathyadipocytepathogenesis |
| spellingShingle | Wei Liu Chao Ma Hao-Yu Li Lan Chen Shan-Si Yuan Kai-Jun Li Effect of abnormal adipose tissue proliferation in thyroid-associated ophthalmopathy Guoji Yanke Zazhi thyroid-associated ophthalmopathy Graves' ophthalmopathy adipocyte pathogenesis |
| title | Effect of abnormal adipose tissue proliferation in thyroid-associated ophthalmopathy |
| title_full | Effect of abnormal adipose tissue proliferation in thyroid-associated ophthalmopathy |
| title_fullStr | Effect of abnormal adipose tissue proliferation in thyroid-associated ophthalmopathy |
| title_full_unstemmed | Effect of abnormal adipose tissue proliferation in thyroid-associated ophthalmopathy |
| title_short | Effect of abnormal adipose tissue proliferation in thyroid-associated ophthalmopathy |
| title_sort | effect of abnormal adipose tissue proliferation in thyroid associated ophthalmopathy |
| topic | thyroid-associated ophthalmopathy Graves' ophthalmopathy adipocyte pathogenesis |
| url | http://ies.ijo.cn/cn_publish/2019/11/201911014.pdf |
| work_keys_str_mv | AT weiliu effectofabnormaladiposetissueproliferationinthyroidassociatedophthalmopathy AT chaoma effectofabnormaladiposetissueproliferationinthyroidassociatedophthalmopathy AT haoyuli effectofabnormaladiposetissueproliferationinthyroidassociatedophthalmopathy AT lanchen effectofabnormaladiposetissueproliferationinthyroidassociatedophthalmopathy AT shansiyuan effectofabnormaladiposetissueproliferationinthyroidassociatedophthalmopathy AT kaijunli effectofabnormaladiposetissueproliferationinthyroidassociatedophthalmopathy |