Inhibition of Plasmodium falciparum plasmepsins by drugs targeting HIV-1 protease: A way forward for antimalarial drug discovery

Inhibition of Plasmodium falciparum plasmepsins by drugs targeting HIV-1 protease: A way forward for antimalarial drug discovery

Plasmodium species are causative agents of malaria, a disease that is a serious global health concern. FDA-approved HIV-1 protease inhibitors (HIV-1 PIs) have been reported to be effective in reducing the infection by Plasmodium parasites in the population co-infected with both HIV-1 and malaria. Ho...

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Bibliographic Details
Main Authors: Vandana Mishra, Anuradha Deshmukh, Ishan Rathore, Satadru Chakraborty, Swati Patankar, Alla Gustchina, Alexander Wlodawer, Rickey Y. Yada, Prasenjit Bhaumik
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Current Research in Structural Biology
Subjects:
Plasmepsins
Protease
Parasite
Malaria
Hemoglobin
Drug design
Online Access:http://www.sciencedirect.com/science/article/pii/S2665928X24000059

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