Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins
Early and persistent activation of complement is considered to play a key role in the pathogenesis of COVID-19. Complement activation products orchestrate a proinflammatory environment that might be critical for the induction and maintenance of a severe inflammatory response to SARS-CoV-2 by recruit...
Main Authors: | Youssif M. Ali, Matteo Ferrari, Nicholas J. Lynch, Sadam Yaseen, Thomas Dudler, Sasha Gragerov, Gregory Demopulos, Jonathan L. Heeney, Wilhelm J. Schwaeble |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-07-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.714511/full |
Similar Items
-
Inhibition of the lectin pathway of complement activation reduces LPS-induced acute respiratory distress syndrome in mice
by: Youssif M. Ali, et al.
Published: (2023-05-01) -
Evasion Mechanisms Used by Pathogens to Escape the Lectin Complement Pathway
by: Anne Rosbjerg, et al.
Published: (2017-05-01) -
Development and characterization of narsoplimab, a selective MASP-2 inhibitor, for the treatment of lectin-pathway–mediated disorders
by: Thomas Dudler, et al.
Published: (2023-11-01) -
Role of the lectin pathway of complement in hematopoietic stem cell transplantation-associated endothelial injury and thrombotic microangiopathy
by: Eleni Gavriilaki, et al.
Published: (2021-12-01) -
Ficolin-2 Lectin Complement Pathway Mediates Capsule-Specific Innate Immunity Against Invasive Pneumococcal Disease
by: Moon H. Nahm, et al.
Published: (2022-03-01)