Effectiveness of corticosteroid therapy in patients with moderate to severe coronavirus disease 2019: a retrospective study
Introduction: Ne An acute respiratory infection started in Wuhan city of China in December 2019. The pathogen was discovered as a novel coronavirus from the Coronaviridae family and called the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). According to clinical symptoms and laboratory...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2023-06-01
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| Series: | Journal of Nephropharmacology |
| Subjects: | |
| Online Access: | https://jnephropharmacology.com/PDF/npj-12-e10577.pdf |
| _version_ | 1827808590617903104 |
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| author | Sara Sadeghi Marjan Mansourian Sara Ebrahimi Baran Kahid Basiri Niloofar Nikgoftar Soheila Jalali Ramin Sami |
| author_facet | Sara Sadeghi Marjan Mansourian Sara Ebrahimi Baran Kahid Basiri Niloofar Nikgoftar Soheila Jalali Ramin Sami |
| author_sort | Sara Sadeghi |
| collection | DOAJ |
| description | Introduction: Ne An acute respiratory infection started in Wuhan city of China in December 2019. The pathogen was discovered as a novel coronavirus from the Coronaviridae family and called the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). According to clinical symptoms and laboratory tests, coronavirus disease 2019 (COVID-19) patients are categorized as asymptomatic, mild, moderate, severe and critical state. Suggested therapies used in moderate to severe COVID-19 disease include corticosteroids, anticoagulation and antiviral drugs (e.g., remdesivir). Objectives: We reviewed the clinical outcomes associated with corticosteroid treatment for COVID-19. Patients and Methods: We planned a retrospective study with 859 patients diagnosed with SARS-CoV-2 infection who were under treatment at Khorshid hospital affiliated with Isfahan University of Medical Sciences, Isfahan, Iran (from February to May 2020). Results: A total of 859 patients were included in this study. The mean age was 63.33±15.45 years of which 43.8% (n=376) were women. We subcategorized corticosteroids by dose prescribed in smaller groups to show better results. The secondary outcome including the rate of intensive care units (ICUs) admission and death was less with corticosteroid prescription. This study showed, mortality and ICU admission were fewer in patients with ≥51 mg/d and ≥201 mg/d of methylprednisolone therapy, respectively. Conclusion: Based on this study, corticosteroid treatment can reduce both the need for ICU admission and mortality in moderate to severe COVID-19 patients. However, clinical trials are needed to investigate the effect of corticosteroid therapy on the need to mechanically ventilate a patient. |
| first_indexed | 2024-03-11T22:29:19Z |
| format | Article |
| id | doaj.art-e723d4a3a9934a2292109a611d68a2e9 |
| institution | Directory Open Access Journal |
| issn | 2345-4202 |
| language | English |
| last_indexed | 2024-03-11T22:29:19Z |
| publishDate | 2023-06-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropharmacology |
| spelling | doaj.art-e723d4a3a9934a2292109a611d68a2e92023-09-23T11:55:53ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropharmacology2345-42022023-06-01122e10577e1057710.34172/npj.2023.10577npj-10577Effectiveness of corticosteroid therapy in patients with moderate to severe coronavirus disease 2019: a retrospective studySara Sadeghi0Marjan Mansourian1Sara Ebrahimi2Baran Kahid Basiri3Niloofar Nikgoftar4Soheila Jalali5Ramin Sami6Medical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Epidemiology and Biostatics, School of Health, Isfahan University of Medical Sciences, Isfahan, IranAlzahra Research Institute, Alzahra University Hospital Isfahan University of Medical Sciences Isfahan, IranGeneral Practitioner, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, IranGeneral Physician, Department of Family and Emergency Medicine, Faculty of Medicine, Isfahan University of Medical Science, Isfahan, IranDepartment of Epidemiology and Biostatics, School of Health, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranIntroduction: Ne An acute respiratory infection started in Wuhan city of China in December 2019. The pathogen was discovered as a novel coronavirus from the Coronaviridae family and called the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). According to clinical symptoms and laboratory tests, coronavirus disease 2019 (COVID-19) patients are categorized as asymptomatic, mild, moderate, severe and critical state. Suggested therapies used in moderate to severe COVID-19 disease include corticosteroids, anticoagulation and antiviral drugs (e.g., remdesivir). Objectives: We reviewed the clinical outcomes associated with corticosteroid treatment for COVID-19. Patients and Methods: We planned a retrospective study with 859 patients diagnosed with SARS-CoV-2 infection who were under treatment at Khorshid hospital affiliated with Isfahan University of Medical Sciences, Isfahan, Iran (from February to May 2020). Results: A total of 859 patients were included in this study. The mean age was 63.33±15.45 years of which 43.8% (n=376) were women. We subcategorized corticosteroids by dose prescribed in smaller groups to show better results. The secondary outcome including the rate of intensive care units (ICUs) admission and death was less with corticosteroid prescription. This study showed, mortality and ICU admission were fewer in patients with ≥51 mg/d and ≥201 mg/d of methylprednisolone therapy, respectively. Conclusion: Based on this study, corticosteroid treatment can reduce both the need for ICU admission and mortality in moderate to severe COVID-19 patients. However, clinical trials are needed to investigate the effect of corticosteroid therapy on the need to mechanically ventilate a patient.https://jnephropharmacology.com/PDF/npj-12-e10577.pdfcovid-19steroidscorticosteroidsmortalitymechanical ventilationintubation |
| spellingShingle | Sara Sadeghi Marjan Mansourian Sara Ebrahimi Baran Kahid Basiri Niloofar Nikgoftar Soheila Jalali Ramin Sami Effectiveness of corticosteroid therapy in patients with moderate to severe coronavirus disease 2019: a retrospective study Journal of Nephropharmacology covid-19 steroids corticosteroids mortality mechanical ventilation intubation |
| title | Effectiveness of corticosteroid therapy in patients with moderate to severe coronavirus disease 2019: a retrospective study |
| title_full | Effectiveness of corticosteroid therapy in patients with moderate to severe coronavirus disease 2019: a retrospective study |
| title_fullStr | Effectiveness of corticosteroid therapy in patients with moderate to severe coronavirus disease 2019: a retrospective study |
| title_full_unstemmed | Effectiveness of corticosteroid therapy in patients with moderate to severe coronavirus disease 2019: a retrospective study |
| title_short | Effectiveness of corticosteroid therapy in patients with moderate to severe coronavirus disease 2019: a retrospective study |
| title_sort | effectiveness of corticosteroid therapy in patients with moderate to severe coronavirus disease 2019 a retrospective study |
| topic | covid-19 steroids corticosteroids mortality mechanical ventilation intubation |
| url | https://jnephropharmacology.com/PDF/npj-12-e10577.pdf |
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