Angiogenesis mechanisms in transplantation of tissue-engineered constructions

There is a number of problems regarding bioengineered structures creation that require further study in the fi eld of regenerative medicine. One of the critical tasks that require solution is the fact that tissue engineered constructions, as a rule, are large, which signifi cantly limits the possibili...

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Main Authors: R. Z. Nakokhov, E. A. Gubareva, E. V. Kuevda, A. S. Sotnichenko, I. S. Gumenyuk, G. M. Mogilnaya, A. H. Kade
Format: Article
Language:Russian
Published: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov 2018-01-01
Series:Vestnik Transplantologii i Iskusstvennyh Organov
Subjects:
Online Access:https://journal.transpl.ru/vtio/article/view/838
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author R. Z. Nakokhov
E. A. Gubareva
E. V. Kuevda
A. S. Sotnichenko
I. S. Gumenyuk
G. M. Mogilnaya
A. H. Kade
author_facet R. Z. Nakokhov
E. A. Gubareva
E. V. Kuevda
A. S. Sotnichenko
I. S. Gumenyuk
G. M. Mogilnaya
A. H. Kade
author_sort R. Z. Nakokhov
collection DOAJ
description There is a number of problems regarding bioengineered structures creation that require further study in the fi eld of regenerative medicine. One of the critical tasks that require solution is the fact that tissue engineered constructions, as a rule, are large, which signifi cantly limits the possibility of diffusion of nutrients and oxygen in them. Thus, the key task of fundamental medicine is to fi nd a technology for restoring the perfusion of the structures created. The article presents a modern overview of the mechanisms of angiogenesis and possible ways of its stimulation during transplantation of tissue engineered constructions.
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spelling doaj.art-e7242870316c4cbe945f53ed74a936ae2023-03-13T10:37:24ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovVestnik Transplantologii i Iskusstvennyh Organov1995-11912018-01-0119414114510.15825/1995-1191-2017-4-141-145671Angiogenesis mechanisms in transplantation of tissue-engineered constructionsR. Z. Nakokhov0E. A. Gubareva1E. V. Kuevda2A. S. Sotnichenko3I. S. Gumenyuk4G. M. Mogilnaya5A. H. Kade6FSBEI HE «Kuban State Medical University».FSBEI HE «Kuban State Medical University».FSBEI HE «Kuban State Medical University».FSBEI HE «Kuban State Medical University».FSBEI HE «Kuban State Medical University».FSBEI HE «Kuban State Medical University».FSBEI HE «Kuban State Medical University».There is a number of problems regarding bioengineered structures creation that require further study in the fi eld of regenerative medicine. One of the critical tasks that require solution is the fact that tissue engineered constructions, as a rule, are large, which signifi cantly limits the possibility of diffusion of nutrients and oxygen in them. Thus, the key task of fundamental medicine is to fi nd a technology for restoring the perfusion of the structures created. The article presents a modern overview of the mechanisms of angiogenesis and possible ways of its stimulation during transplantation of tissue engineered constructions.https://journal.transpl.ru/vtio/article/view/838tissue engineeringangiogenesisgrowth factorsthree-dimensional matricesmultipotent mesenchymal stromal cells
spellingShingle R. Z. Nakokhov
E. A. Gubareva
E. V. Kuevda
A. S. Sotnichenko
I. S. Gumenyuk
G. M. Mogilnaya
A. H. Kade
Angiogenesis mechanisms in transplantation of tissue-engineered constructions
Vestnik Transplantologii i Iskusstvennyh Organov
tissue engineering
angiogenesis
growth factors
three-dimensional matrices
multipotent mesenchymal stromal cells
title Angiogenesis mechanisms in transplantation of tissue-engineered constructions
title_full Angiogenesis mechanisms in transplantation of tissue-engineered constructions
title_fullStr Angiogenesis mechanisms in transplantation of tissue-engineered constructions
title_full_unstemmed Angiogenesis mechanisms in transplantation of tissue-engineered constructions
title_short Angiogenesis mechanisms in transplantation of tissue-engineered constructions
title_sort angiogenesis mechanisms in transplantation of tissue engineered constructions
topic tissue engineering
angiogenesis
growth factors
three-dimensional matrices
multipotent mesenchymal stromal cells
url https://journal.transpl.ru/vtio/article/view/838
work_keys_str_mv AT rznakokhov angiogenesismechanismsintransplantationoftissueengineeredconstructions
AT eagubareva angiogenesismechanismsintransplantationoftissueengineeredconstructions
AT evkuevda angiogenesismechanismsintransplantationoftissueengineeredconstructions
AT assotnichenko angiogenesismechanismsintransplantationoftissueengineeredconstructions
AT isgumenyuk angiogenesismechanismsintransplantationoftissueengineeredconstructions
AT gmmogilnaya angiogenesismechanismsintransplantationoftissueengineeredconstructions
AT ahkade angiogenesismechanismsintransplantationoftissueengineeredconstructions