Apparent Lack of BRAFV600E Derived HLA Class I Presented Neoantigens Hampers Neoplastic Cell Targeting by CD8+ T Cells in Langerhans Cell Histiocytosis

Apparent Lack of BRAFV600E Derived HLA Class I Presented Neoantigens Hampers Neoplastic Cell Targeting by CD8+ T Cells in Langerhans Cell Histiocytosis

Langerhans Cell Histiocytosis (LCH) is a neoplastic disorder of hematopoietic origin characterized by inflammatory lesions containing clonal histiocytes (LCH-cells) intermixed with various immune cells, including T cells. In 50–60% of LCH-patients, the somatic BRAFV600E driver mutation, which is com...

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Dades bibliogràfiques
Autors principals: Paul G. Kemps, Timo C. Zondag, Eline C. Steenwijk, Quirine Andriessen, Jelske Borst, Sandra Vloemans, Dave L. Roelen, Lenard M. Voortman, Robert M. Verdijk, Carel J. M. van Noesel, Arjen H. G. Cleven, Cynthia Hawkins, Veronica Lang, Arnoud H. de Ru, George M. C. Janssen, Geert W. Haasnoot, Kees L. M. C. Franken, Ronald van Eijk, Nienke Solleveld-Westerink, Tom van Wezel, R. Maarten Egeler, Auke Beishuizen, Jan A. M. van Laar, Oussama Abla, Cor van den Bos, Peter A. van Veelen, Astrid G. S. van Halteren
Format: Article
Idioma:English
Publicat: Frontiers Media S.A. 2020-01-01
Col·lecció:Frontiers in Immunology
Matèries:
Langerhans Cell Histiocytosis
BRAF
neoantigen
neopeptide
Human Leukocyte Antigen
T cell
Accés en línia:https://www.frontiersin.org/article/10.3389/fimmu.2019.03045/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03045/full

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