Therapeutic potential for KCC2-targeted neurological diseases

Therapeutic potential for KCC2-targeted neurological diseases

Patients with neurological diseases, such as schizophrenia, tend to show low K+-Cl- co-transporter 2 (KCC2) levels in the brain. The cause of these diseases has been associated with stress and neuroinflammation. However, since the pathogenesis of these diseases is not yet fully investigated, drug th...

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Bibliographic Details
Main Authors: Kazuo Tomita, Yoshikazu Kuwahara, Kento Igarashi, Junichi Kitanaka, Nobue Kitanaka, Yuko Takashi, Koh-ichi Tanaka, Mehryar Habibi Roudkenar, Amaneh Mohammadi Roushandeh, Akihiro Kurimasa, Yoshihiro Nishitani, Tomoaki Sato
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Japanese Dental Science Review
Subjects:
KCC2
GABA
Neurological diseases
Inflammation
Therapeutic target
Online Access:http://www.sciencedirect.com/science/article/pii/S1882761623000376

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