Sensitive, High-Throughput Liquid Chromatography-Tandem Mass Spectrometry Analysis of Atorvastatin and Its Pharmacologically Active Metabolites in Serum for Supporting Precision Pharmacotherapy

Sensitive, High-Throughput Liquid Chromatography-Tandem Mass Spectrometry Analysis of Atorvastatin and Its Pharmacologically Active Metabolites in Serum for Supporting Precision Pharmacotherapy

The antihyerlipidemic drug atorvastatin (ATR) is used worldwide as part of the strategy to prevent cardiovascular events. The high prevalence of patient nonadherence remains an important challenge which could be addressed efficiently by precision pharmacotherapy based on therapeutic drug monitoring...

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Bibliographic Details
Main Authors: Gellért Balázs Karvaly, István Vincze, István Karádi, Barna Vásárhelyi, András Zsáry
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
atorvastatin
hydroxyatorvastatin
atorvastatin lactone
therapeutic drug monitoring
pharmacokinetics
individualized drug therapy
Online Access:https://www.mdpi.com/1420-3049/26/5/1324

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