Early-life adversities and later-life reproductive patterns in women with fully traced reproductive history
Abstract One of the most crucial determinants of early-life development is the experience of childhood adversities. However, limited evidence is available for how these experiences shape later-life reproductive outcomes in women. Here we test the association between early-life adversities and reprod...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-36226-w |
| _version_ | 1827928738670575616 |
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| author | Magdalena Klimek Sonja Entringer Agnieszka Matras Mateusz Blukacz Ilona Nenko Andrzej Galbarczyk Grazyna Jasienska |
| author_facet | Magdalena Klimek Sonja Entringer Agnieszka Matras Mateusz Blukacz Ilona Nenko Andrzej Galbarczyk Grazyna Jasienska |
| author_sort | Magdalena Klimek |
| collection | DOAJ |
| description | Abstract One of the most crucial determinants of early-life development is the experience of childhood adversities. However, limited evidence is available for how these experiences shape later-life reproductive outcomes in women. Here we test the association between early-life adversities and reproductive parameters in women. Post-reproductive women (N = 105; mean age = 59.7; SD = 10.09) were recruited at the Mogielica Human Ecology Study Site in Poland within a traditional population with a low prevalence of birth control usage and fully traced reproductive histories. Reproductive parameters, as well as exposure to early-life abuse and neglect, were assessed using questionnaires. Childhood adversity was associated negatively with age at menarche (p = 0.009). Analyses on specific subtypes revealed that compared to women who did not experience any kind of early-life adversities in childhood, those who were exposed to emotional (p = 0.007) and physical (p = 0.023) neglect had an earlier age at menarche, those who experienced emotional abuse reported an earlier age at first birth (p = 0.035), and those who were exposed to physical abuse gave birth to fewer number of sons (p = 0.010). Our results suggest that women exposed to childhood adversities experience earlier physiological reproductive readiness and timing of the first birth, but their overall biological condition might be impaired as they bear fewer sons. |
| first_indexed | 2024-03-13T06:13:00Z |
| format | Article |
| id | doaj.art-e72988a40c134c6a9e33fbdd103dacb8 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T06:13:00Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e72988a40c134c6a9e33fbdd103dacb82023-06-11T11:12:21ZengNature PortfolioScientific Reports2045-23222023-06-011311910.1038/s41598-023-36226-wEarly-life adversities and later-life reproductive patterns in women with fully traced reproductive historyMagdalena Klimek0Sonja Entringer1Agnieszka Matras2Mateusz Blukacz3Ilona Nenko4Andrzej Galbarczyk5Grazyna Jasienska6Department of Environmental Health, Faculty of Health Sciences, Jagiellonian University Medical CollegeInstitute of Medical Psychology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu BerlinDepartment of Environmental Health, Faculty of Health Sciences, Jagiellonian University Medical CollegeDepartment of Environmental Health, Faculty of Health Sciences, Jagiellonian University Medical CollegeDepartment of Environmental Health, Faculty of Health Sciences, Jagiellonian University Medical CollegeDepartment of Environmental Health, Faculty of Health Sciences, Jagiellonian University Medical CollegeDepartment of Environmental Health, Faculty of Health Sciences, Jagiellonian University Medical CollegeAbstract One of the most crucial determinants of early-life development is the experience of childhood adversities. However, limited evidence is available for how these experiences shape later-life reproductive outcomes in women. Here we test the association between early-life adversities and reproductive parameters in women. Post-reproductive women (N = 105; mean age = 59.7; SD = 10.09) were recruited at the Mogielica Human Ecology Study Site in Poland within a traditional population with a low prevalence of birth control usage and fully traced reproductive histories. Reproductive parameters, as well as exposure to early-life abuse and neglect, were assessed using questionnaires. Childhood adversity was associated negatively with age at menarche (p = 0.009). Analyses on specific subtypes revealed that compared to women who did not experience any kind of early-life adversities in childhood, those who were exposed to emotional (p = 0.007) and physical (p = 0.023) neglect had an earlier age at menarche, those who experienced emotional abuse reported an earlier age at first birth (p = 0.035), and those who were exposed to physical abuse gave birth to fewer number of sons (p = 0.010). Our results suggest that women exposed to childhood adversities experience earlier physiological reproductive readiness and timing of the first birth, but their overall biological condition might be impaired as they bear fewer sons.https://doi.org/10.1038/s41598-023-36226-w |
| spellingShingle | Magdalena Klimek Sonja Entringer Agnieszka Matras Mateusz Blukacz Ilona Nenko Andrzej Galbarczyk Grazyna Jasienska Early-life adversities and later-life reproductive patterns in women with fully traced reproductive history Scientific Reports |
| title | Early-life adversities and later-life reproductive patterns in women with fully traced reproductive history |
| title_full | Early-life adversities and later-life reproductive patterns in women with fully traced reproductive history |
| title_fullStr | Early-life adversities and later-life reproductive patterns in women with fully traced reproductive history |
| title_full_unstemmed | Early-life adversities and later-life reproductive patterns in women with fully traced reproductive history |
| title_short | Early-life adversities and later-life reproductive patterns in women with fully traced reproductive history |
| title_sort | early life adversities and later life reproductive patterns in women with fully traced reproductive history |
| url | https://doi.org/10.1038/s41598-023-36226-w |
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