TEP SNORD12B, SNORA63, and SNORD14E as novel biomarkers for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC)
Abstract Purpose The alterations of RNA profile in tumor-educated platelets (TEPs) have been described as a novel biosource for cancer diagnostics. This study aimed to explore the potential snoRNAs in TEP as biomarkers for diagnostics of hepatitis B virus-related hepatocellular carcinoma (HBV-relate...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
|
| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-023-03179-z |
| _version_ | 1797362883316678656 |
|---|---|
| author | Xuan Zhao Guanxuan Chen Yawen Wu Xiao Li Zhe Zhang Li Xie Xianrang Song Xingguo Song |
| author_facet | Xuan Zhao Guanxuan Chen Yawen Wu Xiao Li Zhe Zhang Li Xie Xianrang Song Xingguo Song |
| author_sort | Xuan Zhao |
| collection | DOAJ |
| description | Abstract Purpose The alterations of RNA profile in tumor-educated platelets (TEPs) have been described as a novel biosource for cancer diagnostics. This study aimed to explore the potential snoRNAs in TEP as biomarkers for diagnostics of hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC). Methods Platelets were isolated using low-speed centrifugation and subjected to a quantitative polymerase chain reaction (qPCR) for snoRNAs detection. Results Down-regulated SNORD12B and SNORD14E as well as up-regulated SNORA63 were identified in TEP from HBV-related HCC, which could act as diagnostic biomarkers for HBV-related HCC as well as the early disease. Besides, TEP SNORD12B, SNORD14E, and SNORA63 facilitate the diagnostic performance of AFP and achieve favorable diagnostics efficiency for HBV-related HCC when combined with platelet parameters. Conclusions Aberrant expression of SNORD12B, SNORA63, and SNORD14E in TEPs could serve as the novel and non-invasive biomarkers for HBV-related HCC diagnosis. |
| first_indexed | 2024-03-08T16:13:50Z |
| format | Article |
| id | doaj.art-e729cbbe33dc498da5907182c1b8d5b2 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-03-08T16:13:50Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-e729cbbe33dc498da5907182c1b8d5b22024-01-07T12:48:05ZengBMCCancer Cell International1475-28672024-01-0124111010.1186/s12935-023-03179-zTEP SNORD12B, SNORA63, and SNORD14E as novel biomarkers for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC)Xuan Zhao0Guanxuan Chen1Yawen Wu2Xiao Li3Zhe Zhang4Li Xie5Xianrang Song6Xingguo Song7Department of Clinical Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical SciencesDepartment of Intensive Care Unit, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical SciencesDepartment of Clinical Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical SciencesDepartment of Clinical Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical SciencesDepartment of Clinical Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical SciencesShandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical SciencesShandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical SciencesDepartment of Clinical Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical SciencesAbstract Purpose The alterations of RNA profile in tumor-educated platelets (TEPs) have been described as a novel biosource for cancer diagnostics. This study aimed to explore the potential snoRNAs in TEP as biomarkers for diagnostics of hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC). Methods Platelets were isolated using low-speed centrifugation and subjected to a quantitative polymerase chain reaction (qPCR) for snoRNAs detection. Results Down-regulated SNORD12B and SNORD14E as well as up-regulated SNORA63 were identified in TEP from HBV-related HCC, which could act as diagnostic biomarkers for HBV-related HCC as well as the early disease. Besides, TEP SNORD12B, SNORD14E, and SNORA63 facilitate the diagnostic performance of AFP and achieve favorable diagnostics efficiency for HBV-related HCC when combined with platelet parameters. Conclusions Aberrant expression of SNORD12B, SNORA63, and SNORD14E in TEPs could serve as the novel and non-invasive biomarkers for HBV-related HCC diagnosis.https://doi.org/10.1186/s12935-023-03179-zTumor-educated platelets (TEPs)HBV-related HCCsnoRNAsSNORD12BSNORA63SNORD14E |
| spellingShingle | Xuan Zhao Guanxuan Chen Yawen Wu Xiao Li Zhe Zhang Li Xie Xianrang Song Xingguo Song TEP SNORD12B, SNORA63, and SNORD14E as novel biomarkers for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) Cancer Cell International Tumor-educated platelets (TEPs) HBV-related HCC snoRNAs SNORD12B SNORA63 SNORD14E |
| title | TEP SNORD12B, SNORA63, and SNORD14E as novel biomarkers for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) |
| title_full | TEP SNORD12B, SNORA63, and SNORD14E as novel biomarkers for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) |
| title_fullStr | TEP SNORD12B, SNORA63, and SNORD14E as novel biomarkers for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) |
| title_full_unstemmed | TEP SNORD12B, SNORA63, and SNORD14E as novel biomarkers for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) |
| title_short | TEP SNORD12B, SNORA63, and SNORD14E as novel biomarkers for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) |
| title_sort | tep snord12b snora63 and snord14e as novel biomarkers for hepatitis b virus related hepatocellular carcinoma hbv related hcc |
| topic | Tumor-educated platelets (TEPs) HBV-related HCC snoRNAs SNORD12B SNORA63 SNORD14E |
| url | https://doi.org/10.1186/s12935-023-03179-z |
| work_keys_str_mv | AT xuanzhao tepsnord12bsnora63andsnord14easnovelbiomarkersforhepatitisbvirusrelatedhepatocellularcarcinomahbvrelatedhcc AT guanxuanchen tepsnord12bsnora63andsnord14easnovelbiomarkersforhepatitisbvirusrelatedhepatocellularcarcinomahbvrelatedhcc AT yawenwu tepsnord12bsnora63andsnord14easnovelbiomarkersforhepatitisbvirusrelatedhepatocellularcarcinomahbvrelatedhcc AT xiaoli tepsnord12bsnora63andsnord14easnovelbiomarkersforhepatitisbvirusrelatedhepatocellularcarcinomahbvrelatedhcc AT zhezhang tepsnord12bsnora63andsnord14easnovelbiomarkersforhepatitisbvirusrelatedhepatocellularcarcinomahbvrelatedhcc AT lixie tepsnord12bsnora63andsnord14easnovelbiomarkersforhepatitisbvirusrelatedhepatocellularcarcinomahbvrelatedhcc AT xianrangsong tepsnord12bsnora63andsnord14easnovelbiomarkersforhepatitisbvirusrelatedhepatocellularcarcinomahbvrelatedhcc AT xingguosong tepsnord12bsnora63andsnord14easnovelbiomarkersforhepatitisbvirusrelatedhepatocellularcarcinomahbvrelatedhcc |