Novel targeted agents for the treatment of bladder cancer: translating laboratory advances into clinical application
Bladder cancer is a common and frequently lethal cancer. Natural history studies indicate two distinct clinical and molecular entities corresponding to invasive and non-muscle invasive disease. The high frequency of recurrence of noninvasive bladder cancer and poor survival rate of invasive bladder...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Urologia
2010-06-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382010000300003 |
| _version_ | 1818411828033617920 |
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| author | Xiaoping Yang Thomas W. Flaig |
| author_facet | Xiaoping Yang Thomas W. Flaig |
| author_sort | Xiaoping Yang |
| collection | DOAJ |
| description | Bladder cancer is a common and frequently lethal cancer. Natural history studies indicate two distinct clinical and molecular entities corresponding to invasive and non-muscle invasive disease. The high frequency of recurrence of noninvasive bladder cancer and poor survival rate of invasive bladder cancer emphasizes the need for novel therapeutic approaches. These mechanisms of tumor development and promotion in bladder cancer are strongly associated with several growth factor pathways including the fibroblast, epidermal, and the vascular endothelial growth factor pathways. In this review, efforts to translate the growing body of basic science research of novel treatments into clinical applications will be explored. |
| first_indexed | 2024-12-14T10:37:37Z |
| format | Article |
| id | doaj.art-e729e9323d6b47fc8e0b7193f8939c5f |
| institution | Directory Open Access Journal |
| issn | 1677-5538 1677-6119 |
| language | English |
| last_indexed | 2024-12-14T10:37:37Z |
| publishDate | 2010-06-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-e729e9323d6b47fc8e0b7193f8939c5f2022-12-21T23:05:51ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-55381677-61192010-06-0136327328210.1590/S1677-55382010000300003Novel targeted agents for the treatment of bladder cancer: translating laboratory advances into clinical applicationXiaoping YangThomas W. FlaigBladder cancer is a common and frequently lethal cancer. Natural history studies indicate two distinct clinical and molecular entities corresponding to invasive and non-muscle invasive disease. The high frequency of recurrence of noninvasive bladder cancer and poor survival rate of invasive bladder cancer emphasizes the need for novel therapeutic approaches. These mechanisms of tumor development and promotion in bladder cancer are strongly associated with several growth factor pathways including the fibroblast, epidermal, and the vascular endothelial growth factor pathways. In this review, efforts to translate the growing body of basic science research of novel treatments into clinical applications will be explored.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382010000300003bladder neoplasmsdrug therapyvascular endothelial growth factorsepidermal growth factorsfibroblast growth factors |
| spellingShingle | Xiaoping Yang Thomas W. Flaig Novel targeted agents for the treatment of bladder cancer: translating laboratory advances into clinical application International Brazilian Journal of Urology bladder neoplasms drug therapy vascular endothelial growth factors epidermal growth factors fibroblast growth factors |
| title | Novel targeted agents for the treatment of bladder cancer: translating laboratory advances into clinical application |
| title_full | Novel targeted agents for the treatment of bladder cancer: translating laboratory advances into clinical application |
| title_fullStr | Novel targeted agents for the treatment of bladder cancer: translating laboratory advances into clinical application |
| title_full_unstemmed | Novel targeted agents for the treatment of bladder cancer: translating laboratory advances into clinical application |
| title_short | Novel targeted agents for the treatment of bladder cancer: translating laboratory advances into clinical application |
| title_sort | novel targeted agents for the treatment of bladder cancer translating laboratory advances into clinical application |
| topic | bladder neoplasms drug therapy vascular endothelial growth factors epidermal growth factors fibroblast growth factors |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382010000300003 |
| work_keys_str_mv | AT xiaopingyang noveltargetedagentsforthetreatmentofbladdercancertranslatinglaboratoryadvancesintoclinicalapplication AT thomaswflaig noveltargetedagentsforthetreatmentofbladdercancertranslatinglaboratoryadvancesintoclinicalapplication |