Arterial spin labeling MRI applied to migraine: current insights and future perspectives
Abstract Introduction Advanced neuroimaging techniques have extensively contributed to elucidate the complex mechanisms underpinning the pathophysiology of migraine, a neurovascular disorder characterized by episodes of headache associated with a constellation of non-pain symptoms. The present manus...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10194-023-01597-y |
| _version_ | 1797801339915337728 |
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| author | Antonio Russo Marcello Silvestro Alessandro Tessitore Ilaria Orologio Alessandro Pasquale De Rosa Rosa De Micco Gioacchino Tedeschi Fabrizio Esposito Mario Cirillo |
| author_facet | Antonio Russo Marcello Silvestro Alessandro Tessitore Ilaria Orologio Alessandro Pasquale De Rosa Rosa De Micco Gioacchino Tedeschi Fabrizio Esposito Mario Cirillo |
| author_sort | Antonio Russo |
| collection | DOAJ |
| description | Abstract Introduction Advanced neuroimaging techniques have extensively contributed to elucidate the complex mechanisms underpinning the pathophysiology of migraine, a neurovascular disorder characterized by episodes of headache associated with a constellation of non-pain symptoms. The present manuscript, summarizing the most recent progresses of the arterial spin labelling (ASL) MRI techniques and the most significant findings from ASL studies conducted in migraine, is aimed to clarify how ASL investigations are contributing to the evolving insight on migraine pathophysiology and their putative role in migraine clinical setting. ASL techniques, allowing to quantitatively demonstrate changes in cerebral blood flow (CBF) both during the attacks and in the course of interictal period, could represent the melting point between advanced neuroimaging investigations, conducted with pure scientific purposes, and conventional neuroimaging approaches, employed in the diagnostic decision-making processes. Main body Converging ASL evidences have demonstrated that abnormal CBF, exceeding the boundaries of a single vascular territory, with biphasic trend dominated by an initial hypoperfusion (during the aura phenomenon but also in the first part of the headache phase) followed by hyperperfusion, characterizes migraine with aura attack and can represent a valuable clinical tool in the differential diagnosis from acute ischemic strokes and epileptic seizures. Studies conducted during migraine without aura attacks are converging to highlight the involvement of dorsolateral pons and hypothalamus in migraine pathophysiology, albeit not able to disentangle their role as “migraine generators” from mere attack epiphenomenon. Furthermore, ASL findings tend to support the presence of perfusion abnormalities in brain regions known to be involved in aura ignition and propagation as well as in areas involved in multisensory processing, in both patients with migraine with aura and migraine without aura. Conclusion Although ASL studies have dramatically clarified quality and timing of perfusion abnormalities during migraine with aura attacks, the same cannot be said for perfusion changes during migraine attacks without aura and interictal periods. Future studies with more rigorous methodological approaches in terms of study protocol, ASL technique and sample selection and size are mandatory to exploit the possibility of better understanding migraine pathophysiology and identifying neuroimaging biomarkers of each migraine phase in different migraine phenotypes. |
| first_indexed | 2024-03-13T04:48:58Z |
| format | Article |
| id | doaj.art-e729efb0c4b444d295738d114a1930e3 |
| institution | Directory Open Access Journal |
| issn | 1129-2377 |
| language | English |
| last_indexed | 2024-03-13T04:48:58Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-e729efb0c4b444d295738d114a1930e32023-06-18T11:20:43ZengBMCThe Journal of Headache and Pain1129-23772023-06-0124111710.1186/s10194-023-01597-yArterial spin labeling MRI applied to migraine: current insights and future perspectivesAntonio Russo0Marcello Silvestro1Alessandro Tessitore2Ilaria Orologio3Alessandro Pasquale De Rosa4Rosa De Micco5Gioacchino Tedeschi6Fabrizio Esposito7Mario Cirillo8Headache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Headache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Headache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Headache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Advanced MRI Neuroimaging Centre, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Headache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Headache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Advanced MRI Neuroimaging Centre, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Advanced MRI Neuroimaging Centre, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Abstract Introduction Advanced neuroimaging techniques have extensively contributed to elucidate the complex mechanisms underpinning the pathophysiology of migraine, a neurovascular disorder characterized by episodes of headache associated with a constellation of non-pain symptoms. The present manuscript, summarizing the most recent progresses of the arterial spin labelling (ASL) MRI techniques and the most significant findings from ASL studies conducted in migraine, is aimed to clarify how ASL investigations are contributing to the evolving insight on migraine pathophysiology and their putative role in migraine clinical setting. ASL techniques, allowing to quantitatively demonstrate changes in cerebral blood flow (CBF) both during the attacks and in the course of interictal period, could represent the melting point between advanced neuroimaging investigations, conducted with pure scientific purposes, and conventional neuroimaging approaches, employed in the diagnostic decision-making processes. Main body Converging ASL evidences have demonstrated that abnormal CBF, exceeding the boundaries of a single vascular territory, with biphasic trend dominated by an initial hypoperfusion (during the aura phenomenon but also in the first part of the headache phase) followed by hyperperfusion, characterizes migraine with aura attack and can represent a valuable clinical tool in the differential diagnosis from acute ischemic strokes and epileptic seizures. Studies conducted during migraine without aura attacks are converging to highlight the involvement of dorsolateral pons and hypothalamus in migraine pathophysiology, albeit not able to disentangle their role as “migraine generators” from mere attack epiphenomenon. Furthermore, ASL findings tend to support the presence of perfusion abnormalities in brain regions known to be involved in aura ignition and propagation as well as in areas involved in multisensory processing, in both patients with migraine with aura and migraine without aura. Conclusion Although ASL studies have dramatically clarified quality and timing of perfusion abnormalities during migraine with aura attacks, the same cannot be said for perfusion changes during migraine attacks without aura and interictal periods. Future studies with more rigorous methodological approaches in terms of study protocol, ASL technique and sample selection and size are mandatory to exploit the possibility of better understanding migraine pathophysiology and identifying neuroimaging biomarkers of each migraine phase in different migraine phenotypes.https://doi.org/10.1186/s10194-023-01597-yMigraine without auraMigraine with auraArterial spin labellingMRICerebral blood flow |
| spellingShingle | Antonio Russo Marcello Silvestro Alessandro Tessitore Ilaria Orologio Alessandro Pasquale De Rosa Rosa De Micco Gioacchino Tedeschi Fabrizio Esposito Mario Cirillo Arterial spin labeling MRI applied to migraine: current insights and future perspectives The Journal of Headache and Pain Migraine without aura Migraine with aura Arterial spin labelling MRI Cerebral blood flow |
| title | Arterial spin labeling MRI applied to migraine: current insights and future perspectives |
| title_full | Arterial spin labeling MRI applied to migraine: current insights and future perspectives |
| title_fullStr | Arterial spin labeling MRI applied to migraine: current insights and future perspectives |
| title_full_unstemmed | Arterial spin labeling MRI applied to migraine: current insights and future perspectives |
| title_short | Arterial spin labeling MRI applied to migraine: current insights and future perspectives |
| title_sort | arterial spin labeling mri applied to migraine current insights and future perspectives |
| topic | Migraine without aura Migraine with aura Arterial spin labelling MRI Cerebral blood flow |
| url | https://doi.org/10.1186/s10194-023-01597-y |
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