Psychological stress creates an immune suppressive environment in the lung that increases susceptibility of aged mice to Mycobacterium tuberculosis infection

Psychological stress creates an immune suppressive environment in the lung that increases susceptibility of aged mice to Mycobacterium tuberculosis infection

Age is a major risk factor for chronic infections, including tuberculosis (TB). Elderly TB patients also suffer from elevated levels of psychological stress. It is not clear how psychological stress impacts immune response to Mycobacterium tuberculosis (M.tb). In this study, we used social disruptio...

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Bibliographic Details
Main Authors: William P. Lafuse, Qian Wu, Naresh Kumar, Noushin Saljoughian, Shrayes Sunkum, Omar Santiagonunez Ahumada, Joanne Turner, Murugesan V. S. Rajaram
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
social stress
aging
Mycobacterium tuberculosis
inflammaging
granuloma
IL10
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.990402/full

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