Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome
BackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that promotes degradation of the low density lipoprotein receptor. PCSK9 has emerged as a target for lipid-lowering therapy, but the predictive value of the serum level of PCSK9 for the severity of coronary dise...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2018-05-01
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| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-42-207.pdf |
| _version_ | 1819182883245391872 |
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| author | Kwi-Hyun Bae Sung Woo Kim Yeon-Kyung Choi Jung Beom Seo Namkyun Kim Chang-Yeon Kim Won Kee Lee Sungwoo Lee Jung Guk Kim In-Kyu Lee Jang Hoon Lee Keun-Gyu Park |
| author_facet | Kwi-Hyun Bae Sung Woo Kim Yeon-Kyung Choi Jung Beom Seo Namkyun Kim Chang-Yeon Kim Won Kee Lee Sungwoo Lee Jung Guk Kim In-Kyu Lee Jang Hoon Lee Keun-Gyu Park |
| author_sort | Kwi-Hyun Bae |
| collection | DOAJ |
| description | BackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that promotes degradation of the low density lipoprotein receptor. PCSK9 has emerged as a target for lipid-lowering therapy, but the predictive value of the serum level of PCSK9 for the severity of coronary disease is largely unknown.MethodsFrom December 2009 to July 2012, 121 individuals who underwent coronary angiography (CAG) because of clinically suspected acute coronary syndrome were enrolled in this study. Serum levels of PCSK9 and metabolic parameters were measured. SYNTAX (SYNergy between percutaneous coronary intervention with [paclitaxel-eluting] TAXUS stent and cardiac surgery) and GRACE (Global Registry of Acute Coronary Events) scores were calculated.ResultsIndividuals with CAG lesions (n=100) had significantly higher levels of PCSK9 than those without lesions (n=21). The study population was stratified into three groups according to serum levels of PCSK9. The odds radio for occurrence of one or more CAG lesions was significantly higher in the group with the highest level of PCSK9 (odds ratio, 7.468; P=0.011) than in the group with the lowest level of PCSK9. Serum PCSK9 was positively associated with the number of involved coronary arteries. Multivariable linear regression indicated that levels of PCSK9 were positively correlated with GRACE risk scores and SYNTAX scores.ConclusionSerum PCSK9 concentrations are higher in patients with coronary artery lesions, and are associated with SYNTAX and GRACE scores, suggesting that PCSK9 is a potential biomarker of the severity of coronary artery disease. |
| first_indexed | 2024-12-22T22:53:12Z |
| format | Article |
| id | doaj.art-e72ad4df36b64fee95079ce459fb619d |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-22T22:53:12Z |
| publishDate | 2018-05-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-e72ad4df36b64fee95079ce459fb619d2022-12-21T18:09:53ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872018-05-0142320721410.4093/dmj.2017.0081Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary SyndromeKwi-Hyun Bae0Sung Woo Kim1Yeon-Kyung Choi2Jung Beom Seo3Namkyun Kim4Chang-Yeon Kim5Won Kee Lee6Sungwoo Lee7Jung Guk Kim8In-Kyu Lee9Jang Hoon Lee10Keun-Gyu Park11Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, .KoreaDepartment of Internal Medicine, Daegu Catholic University Medical Center, Catholic University of Daegu School of Medicine, Daegu, .KoreaDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, .KoreaDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, .KoreaDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, .KoreaDepartment of Internal Medicine, Daegu Catholic University Medical Center, Catholic University of Daegu School of Medicine, Daegu, .KoreaBiostatistics Center, School of Medicine, Kyungpook National University, Daegu, .KoreaNew Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, .KoreaDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, .KoreaDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, .KoreaDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, .KoreaDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, .KoreaBackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that promotes degradation of the low density lipoprotein receptor. PCSK9 has emerged as a target for lipid-lowering therapy, but the predictive value of the serum level of PCSK9 for the severity of coronary disease is largely unknown.MethodsFrom December 2009 to July 2012, 121 individuals who underwent coronary angiography (CAG) because of clinically suspected acute coronary syndrome were enrolled in this study. Serum levels of PCSK9 and metabolic parameters were measured. SYNTAX (SYNergy between percutaneous coronary intervention with [paclitaxel-eluting] TAXUS stent and cardiac surgery) and GRACE (Global Registry of Acute Coronary Events) scores were calculated.ResultsIndividuals with CAG lesions (n=100) had significantly higher levels of PCSK9 than those without lesions (n=21). The study population was stratified into three groups according to serum levels of PCSK9. The odds radio for occurrence of one or more CAG lesions was significantly higher in the group with the highest level of PCSK9 (odds ratio, 7.468; P=0.011) than in the group with the lowest level of PCSK9. Serum PCSK9 was positively associated with the number of involved coronary arteries. Multivariable linear regression indicated that levels of PCSK9 were positively correlated with GRACE risk scores and SYNTAX scores.ConclusionSerum PCSK9 concentrations are higher in patients with coronary artery lesions, and are associated with SYNTAX and GRACE scores, suggesting that PCSK9 is a potential biomarker of the severity of coronary artery disease.https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-42-207.pdfCardiovascular diseasesCoronary angiographyProprotein convertase 9 |
| spellingShingle | Kwi-Hyun Bae Sung Woo Kim Yeon-Kyung Choi Jung Beom Seo Namkyun Kim Chang-Yeon Kim Won Kee Lee Sungwoo Lee Jung Guk Kim In-Kyu Lee Jang Hoon Lee Keun-Gyu Park Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome Diabetes & Metabolism Journal Cardiovascular diseases Coronary angiography Proprotein convertase 9 |
| title | Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome |
| title_full | Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome |
| title_fullStr | Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome |
| title_full_unstemmed | Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome |
| title_short | Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome |
| title_sort | serum levels of pcsk9 are associated with coronary angiographic severity in patients with acute coronary syndrome |
| topic | Cardiovascular diseases Coronary angiography Proprotein convertase 9 |
| url | https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-42-207.pdf |
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