Impulse Oscillometry, Small Airways Disease, and Extra-Fine Formulations in Asthma and Chronic Obstructive Pulmonary Disease: Windows for New Opportunities
Alfredo Chetta,1 Nicola Facciolongo,2 Cosimo Franco,3 Laura Franzini,4 Alessio Piraino,4 Carmelina Rossi4 1Clinica Pneumologica, Università di Parma, Parma, Italy; 2UOC Pneumologia, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy; 3UOC Pneumologia, Ospedale Guglielmo da Saliceto, Piacenza, Italy...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2022-10-01
|
| Series: | Therapeutics and Clinical Risk Management |
| Subjects: | |
| Online Access: | https://www.dovepress.com/impulse-oscillometry-small-airways-disease-and-extra-fine-formulations-peer-reviewed-fulltext-article-TCRM |
| _version_ | 1818027460770398208 |
|---|---|
| author | Chetta A Facciolongo N Franco C Franzini L Piraino A Rossi C |
| author_facet | Chetta A Facciolongo N Franco C Franzini L Piraino A Rossi C |
| author_sort | Chetta A |
| collection | DOAJ |
| description | Alfredo Chetta,1 Nicola Facciolongo,2 Cosimo Franco,3 Laura Franzini,4 Alessio Piraino,4 Carmelina Rossi4 1Clinica Pneumologica, Università di Parma, Parma, Italy; 2UOC Pneumologia, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy; 3UOC Pneumologia, Ospedale Guglielmo da Saliceto, Piacenza, Italy; 4Chiesi Italia SpA, Medical Affairs, Parma, ItalyCorrespondence: Alfredo Chetta, Tel +39 0521.703478, Email alfredoantonio.chetta@unipr.itAbstract: In recent years, the perspective of management of respiratory disease has been gradually changing in light of the increasing evidence of small airways as the major site of airflow obstruction contributing to the development of both COPD and asthma already in early stages of disease. First and foremost, the evidence is redefining disease severity, identifying small airways disease phenotypes and early signs of disease, and revising prevalence and overall epidemiological data as well. Much effort has been put toward the instrumental assessment of small airways’ involvement and early detection. Several clinical trials have evaluated the advantage of extra-fine formulations which can best target the small airways in uncontrolled asthma and severe COPD. Here, we briefly present a practical overview of the role of the small airways in disease, the most appropriate diagnostic methods for quantifying their impairment, and provide some insight into the costs of respiratory management in Italy, especially in sub-optimally controlled disease.Keywords: asthma, chronic obstructive pulmonary disease, small airways, impulse oscillometry, cost, extrafine particles |
| first_indexed | 2024-12-10T04:48:15Z |
| format | Article |
| id | doaj.art-e72df124eb404f7b99f8b55cd3cb4c60 |
| institution | Directory Open Access Journal |
| issn | 1178-203X |
| language | English |
| last_indexed | 2024-12-10T04:48:15Z |
| publishDate | 2022-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Therapeutics and Clinical Risk Management |
| spelling | doaj.art-e72df124eb404f7b99f8b55cd3cb4c602022-12-22T02:01:41ZengDove Medical PressTherapeutics and Clinical Risk Management1178-203X2022-10-01Volume 1896597978693Impulse Oscillometry, Small Airways Disease, and Extra-Fine Formulations in Asthma and Chronic Obstructive Pulmonary Disease: Windows for New OpportunitiesChetta AFacciolongo NFranco CFranzini LPiraino ARossi CAlfredo Chetta,1 Nicola Facciolongo,2 Cosimo Franco,3 Laura Franzini,4 Alessio Piraino,4 Carmelina Rossi4 1Clinica Pneumologica, Università di Parma, Parma, Italy; 2UOC Pneumologia, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy; 3UOC Pneumologia, Ospedale Guglielmo da Saliceto, Piacenza, Italy; 4Chiesi Italia SpA, Medical Affairs, Parma, ItalyCorrespondence: Alfredo Chetta, Tel +39 0521.703478, Email alfredoantonio.chetta@unipr.itAbstract: In recent years, the perspective of management of respiratory disease has been gradually changing in light of the increasing evidence of small airways as the major site of airflow obstruction contributing to the development of both COPD and asthma already in early stages of disease. First and foremost, the evidence is redefining disease severity, identifying small airways disease phenotypes and early signs of disease, and revising prevalence and overall epidemiological data as well. Much effort has been put toward the instrumental assessment of small airways’ involvement and early detection. Several clinical trials have evaluated the advantage of extra-fine formulations which can best target the small airways in uncontrolled asthma and severe COPD. Here, we briefly present a practical overview of the role of the small airways in disease, the most appropriate diagnostic methods for quantifying their impairment, and provide some insight into the costs of respiratory management in Italy, especially in sub-optimally controlled disease.Keywords: asthma, chronic obstructive pulmonary disease, small airways, impulse oscillometry, cost, extrafine particleshttps://www.dovepress.com/impulse-oscillometry-small-airways-disease-and-extra-fine-formulations-peer-reviewed-fulltext-article-TCRMasthmachronic obstructive pulmonary diseasesmall airwaysimpulse oscillometrycostextrafine particles |
| spellingShingle | Chetta A Facciolongo N Franco C Franzini L Piraino A Rossi C Impulse Oscillometry, Small Airways Disease, and Extra-Fine Formulations in Asthma and Chronic Obstructive Pulmonary Disease: Windows for New Opportunities Therapeutics and Clinical Risk Management asthma chronic obstructive pulmonary disease small airways impulse oscillometry cost extrafine particles |
| title | Impulse Oscillometry, Small Airways Disease, and Extra-Fine Formulations in Asthma and Chronic Obstructive Pulmonary Disease: Windows for New Opportunities |
| title_full | Impulse Oscillometry, Small Airways Disease, and Extra-Fine Formulations in Asthma and Chronic Obstructive Pulmonary Disease: Windows for New Opportunities |
| title_fullStr | Impulse Oscillometry, Small Airways Disease, and Extra-Fine Formulations in Asthma and Chronic Obstructive Pulmonary Disease: Windows for New Opportunities |
| title_full_unstemmed | Impulse Oscillometry, Small Airways Disease, and Extra-Fine Formulations in Asthma and Chronic Obstructive Pulmonary Disease: Windows for New Opportunities |
| title_short | Impulse Oscillometry, Small Airways Disease, and Extra-Fine Formulations in Asthma and Chronic Obstructive Pulmonary Disease: Windows for New Opportunities |
| title_sort | impulse oscillometry small airways disease and extra fine formulations in asthma and chronic obstructive pulmonary disease windows for new opportunities |
| topic | asthma chronic obstructive pulmonary disease small airways impulse oscillometry cost extrafine particles |
| url | https://www.dovepress.com/impulse-oscillometry-small-airways-disease-and-extra-fine-formulations-peer-reviewed-fulltext-article-TCRM |
| work_keys_str_mv | AT chettaa impulseoscillometrysmallairwaysdiseaseandextrafineformulationsinasthmaandchronicobstructivepulmonarydiseasewindowsfornewopportunities AT facciolongon impulseoscillometrysmallairwaysdiseaseandextrafineformulationsinasthmaandchronicobstructivepulmonarydiseasewindowsfornewopportunities AT francoc impulseoscillometrysmallairwaysdiseaseandextrafineformulationsinasthmaandchronicobstructivepulmonarydiseasewindowsfornewopportunities AT franzinil impulseoscillometrysmallairwaysdiseaseandextrafineformulationsinasthmaandchronicobstructivepulmonarydiseasewindowsfornewopportunities AT pirainoa impulseoscillometrysmallairwaysdiseaseandextrafineformulationsinasthmaandchronicobstructivepulmonarydiseasewindowsfornewopportunities AT rossic impulseoscillometrysmallairwaysdiseaseandextrafineformulationsinasthmaandchronicobstructivepulmonarydiseasewindowsfornewopportunities |