Tracking motion kinematics and tremor with intrinsic oscillatory property of instrumental mechanics
Abstract Tracking kinematic details of motor behaviors is a foundation to study the neuronal mechanism and biology of motor control. However, most of the physiological motor behaviors and movement disorders, such as gait, balance, tremor, dystonia, and myoclonus, are highly dependent on the overall...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Bioengineering & Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/btm2.10432 |
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| author | Chun‐Lun Ni Yi‐Ting Lin Liang‐Yin Lu Jia‐Huei Wang Wen‐Chuan Liu Sheng‐Han Kuo Ming‐Kai Pan |
| author_facet | Chun‐Lun Ni Yi‐Ting Lin Liang‐Yin Lu Jia‐Huei Wang Wen‐Chuan Liu Sheng‐Han Kuo Ming‐Kai Pan |
| author_sort | Chun‐Lun Ni |
| collection | DOAJ |
| description | Abstract Tracking kinematic details of motor behaviors is a foundation to study the neuronal mechanism and biology of motor control. However, most of the physiological motor behaviors and movement disorders, such as gait, balance, tremor, dystonia, and myoclonus, are highly dependent on the overall momentum of the whole‐body movements. Therefore, tracking the targeted movement and overall momentum simultaneously is critical for motor control research, but it remains an unmet need. Here, we introduce the intrinsic oscillatory property (IOP), a fundamental mechanical principle of physics, as a method for motion tracking in a force plate. The overall kinetic energy of animal motions can be transformed into the oscillatory amplitudes at the designed IOP frequency of the force plate, while the target movement has its own frequency features and can be tracked simultaneously. Using action tremor as an example, we reported that force plate‐based IOP approach has superior performance and reliability in detecting both tremor severity and tremor frequency, showing a lower level of coefficient of variation (CV) compared with video‐ and accelerometer‐based motion tracking methods and their combination. Under the locomotor suppression effect of medications, therapeutic effects on tremor severity can still be quantified by dynamically adjusting the overall locomotor activity detected by IOP. We further validated IOP method in optogenetic‐induced movements and natural movements, confirming that IOP can represent the intensity of general rhythmic and nonrhythmic movements, thus it can be generalized as a common approach to study kinematics. |
| first_indexed | 2024-04-10T00:36:52Z |
| format | Article |
| id | doaj.art-e72f4960c38e418f98bfa342059ea66c |
| institution | Directory Open Access Journal |
| issn | 2380-6761 |
| language | English |
| last_indexed | 2024-04-10T00:36:52Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioengineering & Translational Medicine |
| spelling | doaj.art-e72f4960c38e418f98bfa342059ea66c2023-03-14T16:53:48ZengWileyBioengineering & Translational Medicine2380-67612023-03-0182n/an/a10.1002/btm2.10432Tracking motion kinematics and tremor with intrinsic oscillatory property of instrumental mechanicsChun‐Lun Ni0Yi‐Ting Lin1Liang‐Yin Lu2Jia‐Huei Wang3Wen‐Chuan Liu4Sheng‐Han Kuo5Ming‐Kai Pan6Department of Neurology Columbia University New York New York USAMolecular Imaging Center, National Taiwan University Taipei City TaiwanMolecular Imaging Center, National Taiwan University Taipei City TaiwanMolecular Imaging Center, National Taiwan University Taipei City TaiwanMolecular Imaging Center, National Taiwan University Taipei City TaiwanDepartment of Neurology Columbia University New York New York USAMolecular Imaging Center, National Taiwan University Taipei City TaiwanAbstract Tracking kinematic details of motor behaviors is a foundation to study the neuronal mechanism and biology of motor control. However, most of the physiological motor behaviors and movement disorders, such as gait, balance, tremor, dystonia, and myoclonus, are highly dependent on the overall momentum of the whole‐body movements. Therefore, tracking the targeted movement and overall momentum simultaneously is critical for motor control research, but it remains an unmet need. Here, we introduce the intrinsic oscillatory property (IOP), a fundamental mechanical principle of physics, as a method for motion tracking in a force plate. The overall kinetic energy of animal motions can be transformed into the oscillatory amplitudes at the designed IOP frequency of the force plate, while the target movement has its own frequency features and can be tracked simultaneously. Using action tremor as an example, we reported that force plate‐based IOP approach has superior performance and reliability in detecting both tremor severity and tremor frequency, showing a lower level of coefficient of variation (CV) compared with video‐ and accelerometer‐based motion tracking methods and their combination. Under the locomotor suppression effect of medications, therapeutic effects on tremor severity can still be quantified by dynamically adjusting the overall locomotor activity detected by IOP. We further validated IOP method in optogenetic‐induced movements and natural movements, confirming that IOP can represent the intensity of general rhythmic and nonrhythmic movements, thus it can be generalized as a common approach to study kinematics.https://doi.org/10.1002/btm2.10432essential tremorforce platemotion trackingmovement disorder |
| spellingShingle | Chun‐Lun Ni Yi‐Ting Lin Liang‐Yin Lu Jia‐Huei Wang Wen‐Chuan Liu Sheng‐Han Kuo Ming‐Kai Pan Tracking motion kinematics and tremor with intrinsic oscillatory property of instrumental mechanics Bioengineering & Translational Medicine essential tremor force plate motion tracking movement disorder |
| title | Tracking motion kinematics and tremor with intrinsic oscillatory property of instrumental mechanics |
| title_full | Tracking motion kinematics and tremor with intrinsic oscillatory property of instrumental mechanics |
| title_fullStr | Tracking motion kinematics and tremor with intrinsic oscillatory property of instrumental mechanics |
| title_full_unstemmed | Tracking motion kinematics and tremor with intrinsic oscillatory property of instrumental mechanics |
| title_short | Tracking motion kinematics and tremor with intrinsic oscillatory property of instrumental mechanics |
| title_sort | tracking motion kinematics and tremor with intrinsic oscillatory property of instrumental mechanics |
| topic | essential tremor force plate motion tracking movement disorder |
| url | https://doi.org/10.1002/btm2.10432 |
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